NASDAQ$CRSP
CRISPR Therapeutics AG · Q4 2023 earnings
Q4 2023 earnings · · Investor relations
Briefing
CRISPR Therapeutics reported financial results, highlighted by CASGEVY™ approvals and advancements in clinical trials for gene-editing product candidates.
CRISPR Therapeutics reported a net income of $89.3 million for Q4 2023, a significant turnaround from the net loss of $110.6 million in Q4 2022. The company's cash position remains strong, with over $2.1 billion in pro-forma cash, cash equivalents, and marketable securities as of February 21, 2024, bolstered by a registered direct offering and milestone payments. The company continues to advance its pipeline, including CASGEVY™ and next-generation CAR T cell programs.
- CASGEVY™ received approvals in the U.S., European Union, Great Britain, the Kingdom of Saudi Arabia, and Bahrain.
- Clinical trials are ongoing for next-generation CAR T product candidates, CTX112™ and CTX131™.
- Clinical trials are ongoing for in vivo gene editing product candidates, CTX310™ and CTX320™.
- The company's balance sheet was strengthened with a $280 million registered direct offering, bringing the current cash position to over $2.1 billion.
Headline financials
Revenue & EPS history
CRISPR Therapeutics · Revenue · Quarterly
$201M
Revenue by segment
CRISPR Therapeutics · $762K total across 1 segment · Q1 2022
- Grant Revenue$762K+126.1%100.0%
Forward guidance
CRISPR Therapeutics is focused on advancing its pipeline and clinical trials across various therapeutic areas, including oncology, autoimmune, cardiovascular, and diabetes, with expectations for a catalyst-rich period in the next 12-18 months.
Tailwinds
- Initiate a clinical trial of CTX112 in systemic lupus erythematosus (SLE) in the first half of 2024.
- Initiate a Phase 1 trial of CTX131 in hematologic malignancies, including T- and B-cell malignancies, in the first half of 2024.
- Provide a clinical update in 2024 for next-generation CAR T candidates.
- Expect to nominate additional in vivo programs targeting both rare and common diseases in mid-2024.
- Continue to advance a Phase 1 clinical trial for CTX211 for the treatment of Type 1 Diabetes (T1D).
Headwinds
- Efficacy and safety results from ongoing clinical trials may not continue or be repeated in ongoing or planned clinical trials or may not support regulatory submissions.
- Regulatory authorities may not approve exa-cel on a timely basis or at all.
- Adequate pricing or reimbursement may not be secured to support continued development or commercialization of exa-cel following regulatory approval.
- Clinical trial results may not be favorable.
- One or more of its product candidate programs will not proceed as planned for technical, scientific or commercial reasons.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2023
+2.1%
Avg return
Earnings day
+1.3%
Avg return
5 days after
+1.4%
Avg return
30 days after
48%
19 / 40 earnings
Positive
+22.8%
Q3 2019
Best reaction
-7.7%
Q2 2022
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +2.1% | +2.4% | +6.3% | |
| Q4 2025 | +1.2% | +10.0% | +0.9% | |
| Q3 2025 | -1.0% | -4.7% | +4.5% | |
| Q1 2025 | -0.1% | -3.2% | +7.2% | |
| Q4 2024 | -2.8% | -8.3% | -18.2% | |
| Q3 2024 | +0.3% | +2.0% | -2.1% | |
| Q2 2024 | -3.5% | -8.0% | -11.9% | |
| Q1 2024 | -3.6% | +0.2% | +4.2% | |
| Q4 2023 | +9.5% | +9.3% | -9.0% | |
| Q3 2023 | +14.9% | +4.3% | +39.5% | |
| Q2 2023 | +4.1% | -2.6% | +0.3% | |
| Q1 2023 | +13.7% | +14.5% | +12.5% | |
| Q4 2022 | -1.0% | -5.6% | -15.2% | |
| Q3 2022 | +4.5% | -2.2% | +3.8% | |
| Q2 2022 | -7.7% | -3.4% | -20.1% | |
| Q1 2022 | -1.5% | +8.8% | +53.8% | |
| Q4 2021 | +5.7% | -0.5% | +15.1% | |
| Q3 2021 | -3.0% | -1.8% | -26.9% | |
| Q2 2021 | +1.1% | +1.4% | +3.4% | |
| Q1 2021 | -0.1% | -3.3% | -12.8% | |
| Q4 2020 | -6.8% | -7.5% | -23.3% | |
| Q3 2020 | -1.8% | -12.2% | +23.9% | |
| Q2 2020 | -4.4% | -5.4% | -1.6% | |
| Q1 2020 | -5.5% | -11.9% | +13.3% | |
| Q4 2019 | +2.0% | -2.1% | -34.0% | |
| Q3 2019 | +22.8% | +27.7% | +70.9% | |
| Q2 2019 | -2.3% | -3.9% | -11.2% | |
| Q1 2019 | -2.0% | -1.1% | -10.1% | |
| Q4 2018 | +14.3% | +26.2% | +8.0% | |
| Q3 2018 | +7.5% | +3.2% | +0.0% | |
| Q2 2018 | -2.7% | -2.7% | +3.0% | |
| Q1 2018 | -0.4% | +2.0% | +29.6% | |
| Q4 2017 | +10.2% | +9.7% | -16.0% | |
| Q3 2017 | -6.5% | -2.1% | +4.1% | |
| Q2 2016 | +9.4% | +10.1% | +6.7% | |
| Q2 2017 | +9.4% | +10.1% | +6.7% | |
| Q1 2016 | -0.1% | -2.9% | -14.2% | |
| Q1 2017 | +4.3% | -4.2% | -17.9% | |
| Q4 2016 | +11.1% | +13.3% | -12.4% | |
| Q3 2016 | -7.0% | -1.9% | -3.3% | |
| Q4 2015 | — | — | — | |
| Q3 2015 | — | — | — | |
| Q2 2015 | — | — | — | |
| Q1 2015 | — | — | — |
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