NASDAQ$CRSP

CRISPR Therapeutics AG · Q1 2023 earnings

Q1 2023 earnings · · Investor relations

Briefing

CRISPR Therapeutics experienced strong portfolio momentum and completed regulatory submissions for exa-cel.

CRISPR Therapeutics reported financial results for the first quarter ended March 31, 2023. The company continued to advance its portfolio programs, including regulatory submissions for exa-cel and initiation of clinical trials for next-generation CAR T candidates.

  • Regulatory submissions complete for exagamglogene autotemcel (exa-cel) in the U.S. for transfusion-dependent beta thalassemia (TDT) and severe sickle cell disease (SCD).
  • EU and U.K. submissions validated by European Medicines Agency (EMA) and the Medicines and Healthcare products Regulatory Agency (MHRA).
  • Enrollment and dosing ongoing for CTX110, targeting CD19+ B-cell malignancies, and CTX130, targeting CD70 for the treatment of T cell lymphomas.
  • Initiated clinical trials for next-generation CAR T candidates, CTX112 targeting CD19+ B-cell malignancies and CTX131, targeting CD70+ solid tumors.

Headline financials

Total Revenue

$100M

Previous: $940K+10538.3%
EPS (adj)

-$0.67

Previous: -$2.32+71.1%
Capital Expenditures

-$3.06M

Previous: -$15.4M+80.1%
Free Cash Flow

-$56.1M

Previous: -$195M+71.2%
Net Income

-$53.1M

Previous: -$179M+70.4%
Operating Income

-$64.5M

Previous: -$176M+63.4%
Gross Profit

$57.8M

Previous: -$30.5M+289.7%
Cash & Equivalents

$344M

Previous: $684M-49.6%
Total Assets

$2.24B

Previous: $2.61B-13.9%
Stock-Based Comp

$20.9M

Previous: $25.7M-18.9%

Revenue & EPS history

CRISPR Therapeutics · Revenue · Quarterly

$100M

Q1 2023+10,538.3%vs Q1 2022
Beat estimate in 5 of 15 quarters(33%)
ActualEstimate

Revenue by segment

CRISPR Therapeutics · $762K total across 1 segment · Q1 2022

  • Grant Revenue
    $762K+126.1%

Forward guidance

CRISPR Therapeutics expects to move multiple programs utilizing in vivo approaches into the clinic within the next 12 months and continues to advance CTX310 into clinical trials this year.

Tailwinds

  • Ongoing progress with in vivo approaches for liver gene editing.
  • Advancing CTX310, targeting ANGPTL3, into clinical trials this year.
  • Potential for exa-cel to become the first approved CRISPR-based therapy.
  • Advancing next-generation CAR T candidates, CTX112 and CTX131, into clinical trials.
  • Collaboration with Vertex and ViaCyte for therapeutic products in the diabetes field.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q1 2023

Historical avgQ1 2023

+2.1%

Avg return

Earnings day

+1.3%

Avg return

5 days after

+1.4%

Avg return

30 days after

48%

19 / 40 earnings

Positive

+22.8%

Q3 2019

Best reaction

-7.7%

Q2 2022

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q1 2026+2.1%+2.4%+6.3%
Q4 2025+1.2%+10.0%+0.9%
Q3 2025-1.0%-4.7%+4.5%
Q1 2025-0.1%-3.2%+7.2%
Q4 2024-2.8%-8.3%-18.2%
Q3 2024+0.3%+2.0%-2.1%
Q2 2024-3.5%-8.0%-11.9%
Q1 2024-3.6%+0.2%+4.2%
Q4 2023+9.5%+9.3%-9.0%
Q3 2023+14.9%+4.3%+39.5%
Q2 2023+4.1%-2.6%+0.3%
Q1 2023+13.7%+14.5%+12.5%
Q4 2022-1.0%-5.6%-15.2%
Q3 2022+4.5%-2.2%+3.8%
Q2 2022-7.7%-3.4%-20.1%
Q1 2022-1.5%+8.8%+53.8%
Q4 2021+5.7%-0.5%+15.1%
Q3 2021-3.0%-1.8%-26.9%
Q2 2021+1.1%+1.4%+3.4%
Q1 2021-0.1%-3.3%-12.8%
Q4 2020-6.8%-7.5%-23.3%
Q3 2020-1.8%-12.2%+23.9%
Q2 2020-4.4%-5.4%-1.6%
Q1 2020-5.5%-11.9%+13.3%
Q4 2019+2.0%-2.1%-34.0%
Q3 2019+22.8%+27.7%+70.9%
Q2 2019-2.3%-3.9%-11.2%
Q1 2019-2.0%-1.1%-10.1%
Q4 2018+14.3%+26.2%+8.0%
Q3 2018+7.5%+3.2%+0.0%
Q2 2018-2.7%-2.7%+3.0%
Q1 2018-0.4%+2.0%+29.6%
Q4 2017+10.2%+9.7%-16.0%
Q3 2017-6.5%-2.1%+4.1%
Q2 2016+9.4%+10.1%+6.7%
Q2 2017+9.4%+10.1%+6.7%
Q1 2016-0.1%-2.9%-14.2%
Q1 2017+4.3%-4.2%-17.9%
Q4 2016+11.1%+13.3%-12.4%
Q3 2016-7.0%-1.9%-3.3%
Q4 2015
Q3 2015
Q2 2015
Q1 2015

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