NASDAQ$SAGE

Sage Therapeutics Inc · Q4 2023 earnings

Q4 2023 earnings · · Investor relations

Briefing

Sage reported Q4 2023 financial results and pipeline progress, highlighted by the commercial availability of ZURZUVAE and encouraging early launch results.

Sage Therapeutics reported $0.8 million in collaboration revenue from ZURZUVAE in Q4 2023, marking its commercial availability in mid-December. The company achieved a net loss of $32.7 million for the quarter, with cash, cash equivalents, and marketable securities totaling $753 million at year-end.

  • ZURZUVAE commercially available mid-December, generating $0.8 million in collaboration revenue.
  • Approximately 120 prescriptions for ZURZUVAE were written in December.
  • Sage completed screening in the Phase 2b KINETIC 2 study of SAGE-324 in essential tremor.
  • Cash, cash equivalents and marketable securities totaled $753 million at the end of 2023.

Headline financials

Total Revenue

$78M

Previous: $2.87M+2621.5%
EPS (adj)

-$0.55

Previous: -$2.47+77.7%
Capital Expenditures

$112K

Previous: $282K-60.3%
Net Income

-$32.7M

Previous: -$147M+77.8%
Operating Income

-$42.1M

Previous: -$154M+72.7%
Gross Profit

$77.2M

Previous: $2.72M+2734.4%
R&D Expense

$64.3M

No prior period
Stock-Based Comp

$12.9M

Previous: $15.2M-15.1%

Revenue & EPS history

Sage · Revenue · Quarterly

$78M

Q4 2023+2,621.5%vs Q4 2022
Beat estimate in 6 of 15 quarters(40%)
ActualEstimate

Revenue by segment

Sage · $1.64M total across 1 segment · Q4 2021

  • ZULRESSO Net Revenue
    $1.64M

Forward guidance

Sage anticipates that its existing cash, cash equivalents and marketable securities, along with the milestone payment received in January 2024, anticipated funding from ongoing collaborations, and estimated revenues, will support its operations into 2026. The Company anticipates operating expenses will decrease in 2024 relative to 2023. With the availability of ZURZUVAE as an additional treatment for women with PPD, the Company anticipates ZULRESSO revenues will decrease over time.

Tailwinds

  • Existing cash, cash equivalents and marketable securities, along with milestone payments, anticipated funding from ongoing collaborations, and estimated revenues, will support operations into 2026.
  • Operating expenses are anticipated to decrease in 2024 relative to 2023.
  • Broader complement of capabilities for commercializing ZURZUVAE in the treatment of women with PPD is expected in early 2024.
  • Additional analyses of data from NEST clinical program, including health economics and patient reported outcomes, will be presented in 2024.
  • Topline data from PRECEDENT Study in people with MCI associated with PD is expected in early 2024.

Headwinds

  • The Company does not anticipate receipt of any milestone payments from collaborations in the remainder of 2024.
  • ZULRESSO revenues are anticipated to decrease over time with the availability of ZURZUVAE.
  • Topline data from SURVEYOR Study in people with HD cognitive impairment is expected in mid-2024.
  • Topline data from LIGHTWAVE Study in people with MCI and mild dementia due to AD is expected in late 2024.
  • Topline data from DIMENSION Study in people with HD cognitive impairment is expected in late 2024.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 15 quarterly earnings reports · overlaid with Q4 2023

Historical avgQ4 2023

-2.8%

Avg return

Earnings day

-5.3%

Avg return

5 days after

-6.4%

Avg return

30 days after

43%

19 / 44 earnings

Positive

+12.4%

Q4 2021

Best reaction

-47.6%

Q2 2023

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q4 2025
Q3 2025
Q2 2025
Q1 2025-4.1%-5.7%-15.0%
Q4 2024-0.4%-0.8%+7.2%
Q3 2024-24.6%-29.1%-35.2%
Q2 2024-9.6%-17.2%-22.1%
Q1 2024-2.2%-0.6%-19.4%
Q4 2023+10.4%+1.3%-13.2%
Q3 2023-10.2%-17.1%+1.3%
Q2 2023-47.6%-39.7%-42.8%
Q1 2023-2.4%+0.9%+1.9%
Q4 2022+0.9%-5.2%-5.2%
Q3 2022-5.0%+5.0%+16.5%
Q2 2022+4.6%+21.6%+12.8%
Q1 2022+4.9%-12.2%+12.6%
Q4 2021+12.4%+12.3%-1.0%
Q3 2021+11.2%+6.4%-9.7%
Q2 2021-4.0%-5.1%+9.0%
Q1 2021-10.3%
Q4 2020+4.0%
Q3 2020-0.6%
Q2 2020+1.3%
Q1 2020-4.1%
Q4 2019-26.2%
Q3 2019-0.2%
Q2 2019+7.4%
Q1 2019+0.3%
Q4 2018-8.2%
Q3 2018+3.0%
Q2 2018-0.7%
Q1 2018+1.2%
Q4 2017+0.2%
Q3 2017+11.7%
Q2 2017+7.7%
Q1 2017-2.7%
Q4 2016+0.6%
Q3 2016+0.5%
Q2 2016-13.3%
Q1 2016-3.8%
Q4 2015-4.8%
Q3 2015-4.6%
Q2 2015-6.5%
Q1 2015+2.0%
Q4 2014+2.1%
Q3 2014-5.2%
Q2 2014-7.8%
Q4 2013
Q3 2013
Q2 2013
Q1 2013

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