NASDAQ$DAWN

Day One Biopharmaceuticals Inc · Q4 2021 earnings

Q4 2021 earnings · · Investor relations

Briefing

Announced fourth quarter and full year 2021 financial results and highlighted recent corporate achievements.

Day One Biopharmaceuticals reported fourth quarter 2021 financial results, with cash and cash equivalents totaling $284.3 million. Research and development expenses were $11.2 million, and general and administrative expenses were $10.8 million. Net loss totaled $21.9 million for the quarter.

  • Initial data from FIREFLY-1 study with DAY101 (tovorafenib) expected in June 2022.
  • Targeted enrollment achieved in pivotal FIREFLY-1 study.
  • Topline results from pivotal FIREFLY-1 study expected in Q1 2023.
  • Current cash provides runway into 2024 and through multiple expected key clinical milestones.

Headline financials

EPS (adj)

$0.36

Previous: -$7.33+104.9%
Free Cash Flow

-$13.2M

Previous: -$5.94M-121.8%
Net Income

-$21.9M

Previous: -$34.4M+36.3%
Operating Income

-$122M

Previous: -$6.14M-1884.6%
Cash & Equivalents

$284M

Previous: $43.7M+550.2%
Total Assets

$290M

Previous: $45.7M+534.7%

Revenue & EPS history

Day One · Revenue · Quarterly

$52.8M

Q4 2025-59.7%vs Q4 2024
Beat estimate in 3 of 3 quarters(100%)
ActualEstimate

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q4 2021

Historical avgQ4 2021

-1.4%

Avg return

Earnings day

-2.1%

Avg return

5 days after

+1.2%

Avg return

30 days after

45%

9 / 20 earnings

Positive

+23.6%

Q2 2022

Best reaction

-16.6%

Q4 2020

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q4 2025-9.2%-13.9%+78.0%
Q3 2025+0.0%+3.7%+34.8%
Q2 2025-15.4%-14.2%+9.7%
Q1 2025-9.6%-5.9%+2.9%
Q4 2024-16.5%-30.2%-31.7%
Q3 2024+2.6%+3.2%-2.9%
Q2 2024-6.8%-9.4%-11.0%
Q1 2024-0.5%-6.8%-23.9%
Q4 2023+14.5%+15.0%+4.0%
Q3 2023-3.1%-11.1%-3.7%
Q2 2023+1.3%+4.3%+9.6%
Q1 2023+12.7%+10.3%+7.3%
Q4 2022+5.3%-4.2%-32.8%
Q3 2022+2.7%+10.6%+14.3%
Q2 2022+23.6%+18.9%+24.4%
Q1 2022+8.5%+21.8%-6.1%
Q4 2021+3.7%-3.8%-6.9%
Q3 2021-9.2%-15.7%-31.7%
Q2 2021-16.6%-7.6%-5.2%
Q4 2020-16.6%-7.6%-5.2%
Q1 2021
Q3 2020
Q2 2020
Q1 2020

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