NASDAQ$ANNX

Annexon Inc · Q4 2020 earnings

Q4 2020 earnings · · Investor relations

Briefing

Annexon reported fourth quarter and full-year 2020 financial results and business highlights.

Annexon reported a net loss of $23.2 million for the quarter ended December 31, 2020, compared to a net loss of $8.9 million for the quarter ended December 31, 2019. The company's cash and cash equivalents and short-term investments were $351.2 million as of December 31, 2020.

  • Completed evaluation of drug-drug interaction study of ANX005 co-administered with Intravenous Immunoglobulin (IVIg) in 14 patients with GBS.
  • Initiated a Phase 2 trial evaluating the efficacy of ANX007 in reducing the area of GA in patients with GA.
  • Appointed William H. Carson, M.D. to the Board of Directors.
  • Thomas G. Wiggans was appointed as Annexon’s chairman.

Headline financials

EPS (adj)

-$0.61

Previous: -$0.68+10.5%
Net Income

-$23.2M

Previous: -$8.94M-159.4%
Operating Income

-$23.2M

Previous: -$9.13M-154.0%
Cash & Equivalents

$269M

No prior period
Total Assets

$356M

No prior period

Revenue & EPS history

Annexon · Revenue · Quarterly

$0

Q3 2025

Forward guidance

Annexon is rapidly advancing multiple Phase 2 clinical programs across a diverse set of potential indications, and accelerating development of a number of innovative, next generation product candidates. This clinical momentum coupled with our strong capital position positions us well to drive value in 2021 and beyond.

Tailwinds

  • Advancement of the company’s clinical and preclinical programs
  • Timing of data from clinical trials and submission of data to peer-reviewed forums
  • Confidence in the company’s product candidates
  • The company’s ability to drive value in 2021 and beyond
  • Implementation of the company’s business model and strategic plans for its business and product candidates, including potential treatment indications and additional indications that the company may pursue

Headwinds

  • The company’s history of net operating losses
  • The company’s ability to obtain necessary capital to fund its clinical programs
  • The early stages of clinical development of the company’s product candidates
  • The effects of COVID-19 or other public health crises on the company’s clinical programs and business operations
  • The company’s ability to obtain regulatory approval of and successfully commercialize its product candidates

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q4 2020

Historical avgQ4 2020

+3.0%

Avg return

Earnings day

+2.5%

Avg return

5 days after

+1.8%

Avg return

30 days after

64%

14 / 22 earnings

Positive

+23.1%

Q1 2022

Best reaction

-8.1%

Q4 2020

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q4 2026-6.9%-4.6%-7.4%
Q3 2025-0.7%-9.1%+69.1%
Q1 2025+9.4%+8.8%+37.6%
Q4 2024+3.3%+15.5%-23.4%
Q3 2024-6.6%-16.6%-32.2%
Q2 2024+3.8%+11.3%+12.8%
Q1 2024+1.5%-8.8%+27.2%
Q4 2023+17.6%+8.0%-30.9%
Q3 2023+16.7%+22.4%+23.8%
Q2 2023-1.2%-2.1%-26.6%
Q1 2023+4.2%+3.7%-40.7%
Q4 2022+3.8%-8.0%-15.0%
Q3 2022-0.4%+16.6%+15.8%
Q2 2022+3.1%+17.2%+10.2%
Q1 2022+23.1%+25.0%+51.2%
Q4 2021-5.1%-11.0%-43.8%
Q3 2021+1.3%+0.2%-3.4%
Q2 2021-4.6%-13.7%+11.6%
Q1 2021+1.1%+9.3%+12.6%
Q4 2020-8.1%-17.4%-29.5%
Q3 2020+3.5%+9.1%+13.0%
Q2 2020+6.6%-1.2%+8.9%
Q1 2020
Q4 2019
Q3 2019
Q2 2019
Q1 2019
Q4 2018
Q3 2018
Q2 2018
Q1 2018

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