NASDAQ$ANNX

Annexon Inc · Q2 2025 earnings

Q2 2025 earnings · · After market close · Investor relations

Briefing

Annexon Inc reported a net loss of $49.2 million for the second quarter ended June 30, 2025.

Annexon Inc, a clinical-stage biopharmaceutical company, reported its Q2 2025 results with a net loss of $49.2 million, primarily due to R&D expenses of $44.2 million. The company maintained a strong liquidity position with $227.0 million in cash, cash equivalents and short-term investments, expected to fund operations for at least twelve months. No revenue was generated as the company continues to advance its clinical pipeline.

  • Net loss of $49.2 million for the three months ended June 30, 2025
  • R&D expenses increased to $44.2 million, reflecting advancement of clinical programs
  • Cash, cash equivalents and short-term investments totaled $227.0 million
  • Weighted average shares outstanding were 148.3 million, resulting in EPS of $(0.34)

Headline financials

Total Revenue

$0.00

Previous: $0.00
EPS (adj)

-$0.34

Previous: -$0.23-47.8%
R&D Expenses

$44.2M

Previous: $25M+76.5%
G&A Expenses

$7.57M

Previous: $8.55M-11.6%
Total Operating Expenses

$51.7M

Previous: $33.6M+54.0%
Interest and Other Income, Net

$2.57M

Previous: $3.97M-35.3%
Weighted Avg Shares Outstanding

148.3M

Previous: 130.1M+14.0%
Cash and Short-term Investments

$227M

No prior period
Net Income

-$49.2M

Previous: -$29.6M-66.0%
Operating Income

-$51.7M

Previous: -$33.6M-54.0%
Cash & Equivalents

$132M

No prior period

Revenue & EPS history

Annexon · Revenue · Quarterly

$0

Q2 2025

Forward guidance

Existing cash and short-term investments are projected to fund operating expenses and capital requirements for at least twelve months from the financial statement issuance date.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 19 quarterly earnings reports

Historical avg

+3.0%

Avg return

Earnings day

+2.5%

Avg return

5 days after

+1.8%

Avg return

30 days after

64%

14 / 22 earnings

Positive

+23.1%

Q1 2022

Best reaction

-8.1%

Q4 2020

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q2 2025
Q4 2026-6.9%-4.6%-7.4%
Q3 2025-0.7%-9.1%+69.1%
Q1 2025+9.4%+8.8%+37.6%
Q4 2024+3.3%+15.5%-23.4%
Q3 2024-6.6%-16.6%-32.2%
Q2 2024+3.8%+11.3%+12.8%
Q1 2024+1.5%-8.8%+27.2%
Q4 2023+17.6%+8.0%-30.9%
Q3 2023+16.7%+22.4%+23.8%
Q2 2023-1.2%-2.1%-26.6%
Q1 2023+4.2%+3.7%-40.7%
Q4 2022+3.8%-8.0%-15.0%
Q3 2022-0.4%+16.6%+15.8%
Q2 2022+3.1%+17.2%+10.2%
Q1 2022+23.1%+25.0%+51.2%
Q4 2021-5.1%-11.0%-43.8%
Q3 2021+1.3%+0.2%-3.4%
Q2 2021-4.6%-13.7%+11.6%
Q1 2021+1.1%+9.3%+12.6%
Q4 2020-8.1%-17.4%-29.5%
Q3 2020+3.5%+9.1%+13.0%
Q2 2020+6.6%-1.2%+8.9%
Q1 2020
Q4 2019
Q3 2019
Q2 2019
Q1 2019
Q4 2018
Q3 2018
Q2 2018
Q1 2018

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