NASDAQ$AGIO

Agios Pharmaceuticals Inc · Q2 2022 earnings

Q2 2022 earnings · · Investor relations

Briefing

Agios reported business highlights and financial results, generating $3.1 million in U.S. net revenue for PYRUKYND sales.

Agios Pharmaceuticals reported Q2 2022 financial results, including $3.1 million in U.S. net revenue from PYRUKYND sales and $2.5 million from licensing intellectual property. The company had $1.1 billion in cash, cash equivalents, and marketable securities as of June 30, 2022.

  • Generated $3.1 million in U.S. net revenue from PYRUKYND® sales, the first full quarter following FDA approval.
  • Initiated Phase 3 ACTIVATE-kids and ACTIVATE-kidsT studies of PYRUKYND® in pediatric patients with PK deficiency.
  • Brian Goff to become Chief Executive Officer at Agios on August 8, 2022.
  • Evolved Agios’ research approach to focus on advancing existing preclinical programs and in-licensing or acquiring well-characterized, high-potential assets.

Headline financials

Total Revenue

$5.58M

Previous: $0.00
EPS (adj)

-$1.68

Previous: -$1.44-16.7%
Capital Expenditures

-$4.73M

Previous: $249K-1999.6%
Free Cash Flow

-$96.5M

Previous: -$118M+17.9%
Net Income

-$91.8M

Previous: -$86.2M-6.5%
Operating Income

-$97.6M

Previous: -$91.2M-7.0%
Gross Profit

$5.15M

No prior period
Cash & Equivalents

$88.5M

Previous: $1.73B-94.9%
Total Assets

$1.25B

Previous: $1.87B-33.2%
Stock-Based Comp

$11.2M

Previous: $14.9M-25.0%

Revenue & EPS history

Agios · Revenue · Quarterly

$5.58M

Q2 2022
Beat estimate in 6 of 12 quarters(50%)
ActualEstimate

Forward guidance

Agios expects to execute on key milestones and priorities in 2022.

Tailwinds

  • Receive European Medicines Agency (EMA) regulatory decision for PYRUKYND® in adults with PK deficiency by year-end.
  • Enroll a meaningful portion of patients in the Phase 3 ENERGIZE and ENERGIZE-T studies of PYRUKYND® in not regularly transfused and regularly transfused adults with thalassemia, respectively, by year-end.
  • Complete enrollment in the Phase 2 portion of the RISE UP study of PYRUKYND® in sickle cell disease by year-end.
  • Initiate Phase 2a study of AG-946 in adults with low- to intermediate-risk MDS by year-end.
  • Continue to publish clinical and translational data supporting the utility of PK activators across key disease areas and elucidating the burden of disease for PK deficiency, thalassemia and sickle cell disease.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q2 2022

Historical avgQ2 2022

-0.0%

Avg return

Earnings day

+0.5%

Avg return

5 days after

+1.9%

Avg return

30 days after

50%

25 / 50 earnings

Positive

+19.2%

Q2 2022

Best reaction

-15.0%

Q1 2020

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q1 2026-0.1%+11.1%+18.5%
Q4 2025+1.3%+0.4%+0.5%
Q3 2025+2.8%-4.7%-30.4%
Q1 2025+4.2%-4.6%+8.1%
Q4 2024+1.5%+2.4%-5.7%
Q3 2024-3.1%+0.9%+28.3%
Q2 2024-5.3%-8.2%-1.1%
Q1 2024+2.6%-2.6%+8.0%
Q4 2023+2.4%+4.6%+15.6%
Q3 2023+5.6%+9.1%+7.5%
Q2 2023-2.0%+0.1%+8.4%
Q1 2023+11.7%+11.1%+13.9%
Q4 2022-5.3%-4.6%-18.0%
Q3 2022-6.9%-2.0%+13.3%
Q2 2022+19.2%+9.7%+27.7%
Q1 2022-6.3%-9.7%-18.5%
Q4 2021+11.8%+16.9%+4.5%
Q3 2021-7.3%-9.1%-31.3%
Q2 2021-3.8%-5.8%-9.9%
Q1 2021+0.7%-3.4%+0.6%
Q4 2020-10.3%-7.5%-6.1%
Q3 2020-5.5%+0.2%+7.7%
Q2 2020-8.3%-10.7%-18.9%
Q1 2020-15.0%-9.4%+18.8%
Q4 2019+4.3%+7.9%-24.9%
Q3 2019+6.4%+9.2%+23.0%
Q2 2019-12.6%-15.5%-21.1%
Q1 2019+3.2%-5.1%-13.2%
Q4 2018+9.7%+6.8%+20.3%
Q3 2018+11.6%+13.1%+4.3%
Q2 2018-9.0%-7.3%-6.9%
Q1 2018-0.9%+1.1%+17.5%
Q4 2017+3.0%+1.5%+8.4%
Q3 2017+0.0%+3.6%-4.8%
Q2 2017-0.8%-3.6%+4.5%
Q1 2017+6.8%+7.5%+5.1%
Q4 2016+17.3%+9.3%+16.3%
Q3 2016+7.3%+17.2%+23.6%
Q2 2016-6.3%-11.0%-21.0%
Q1 2016-7.2%
Q4 2015-8.3%
Q3 2015-2.6%
Q2 2015-12.4%
Q1 2015+13.3%
Q4 2014-7.3%
Q3 2014-1.6%
Q2 2014+1.4%
Q1 2014-10.3%
Q3 2013+3.2%
Q2 2013+6.4%
Q4 2013
Q3 2012
Q2 2012
Q1 2012

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