NYSE$PFE
Pfizer · Q4 2025 earnings
Q4 2025 earnings · · Before market open · Investor relations
Briefing
Pfizer reported Q4 2025 revenues of $17.6B with a GAAP diluted loss of $0.29 and adjusted EPS of $0.66.
Fourth-quarter revenues were $17.6 billion, down 3% operationally, while the non-COVID portfolio grew 9% operationally excluding Paxlovid and Comirnaty. GAAP results included a large impairment charge driving a $(0.29) diluted LPS; adjusted diluted EPS was $0.66. Management reaffirmed 2026 revenue of $59.5–62.5 billion and adjusted EPS of $2.80–3.00.
- Q4 revenues $17.6B; non-COVID portfolio +9% operationally.
- GAAP LPS $(0.29); adjusted EPS $0.66.
- Full-year revenues $62.6B; adjusted EPS $3.22.
- 2026 revenue guide $59.5B–$62.5B reaffirmed.
Headline financials
Revenue & EPS history
Pfizer · Revenue · Quarterly
$17.6B
Revenue by segment
Pfizer · $12.9B total across 1 segment · Q3 2023
- Biopharma$12.9B-42.1%100.0%
Forward guidance
The release discusses Pfizer's outlook for upcoming periods, including capital allocation, operating priorities, and market risks, without relying solely on numeric EPS bridges.
Tailwinds
- Pfizer cites operational execution and demand trends supporting the outlook.
- Balance sheet and liquidity actions aim to fund growth and returns.
- 2026 revenue and adjusted EPS guidance reaffirmed.
Headwinds
- GAAP profitability remained under pressure in Q4 2025.
- Macro, pricing, and input-cost volatility could pressure margins.
- Segment mix and one-time items may affect quarter-to-quarter comparability.
- LOE headwinds and COVID-product revenue decline weigh on the outlook.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2025
-0.3%
Avg return
Earnings day
-0.3%
Avg return
5 days after
+0.1%
Avg return
30 days after
50%
36 / 72 earnings
Positive
+8.1%
Q1 2024
Best reaction
-10.0%
Q2 2019
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | -0.2% | -2.5% | -2.3% | |
| Q4 2025 | -3.3% | +2.1% | -0.2% | |
| Q3 2025 | -1.5% | -0.9% | +4.2% | |
| Q1 2025 | +3.2% | +5.0% | +1.7% | |
| Q4 2024 | -1.3% | -1.8% | +0.2% | |
| Q3 2024 | -1.2% | -2.7% | -10.5% | |
| Q2 2024 | -0.6% | -0.9% | -6.5% | |
| Q1 2024 | +8.1% | +9.9% | +11.9% | |
| Q4 2023 | -1.5% | -2.0% | -3.3% | |
| Q3 2023 | -0.1% | +2.3% | -0.3% | |
| Q2 2023 | -2.0% | -2.9% | -1.9% | |
| Q1 2023 | -1.9% | -1.8% | -3.0% | |
| Q4 2022 | +1.0% | +1.2% | -6.7% | |
| Q3 2022 | +1.1% | +1.4% | +9.7% | |
| Q2 2022 | -2.8% | -4.4% | -9.9% | |
| Q1 2022 | +2.7% | +1.4% | +9.0% | |
| Q4 2021 | -3.3% | -4.6% | -7.5% | |
| Q3 2021 | +2.7% | +11.4% | +21.5% | |
| Q2 2021 | +1.6% | +4.4% | +10.7% | |
| Q1 2021 | +0.4% | -0.6% | -2.2% | |
| Q4 2020 | -2.7% | -2.5% | -4.5% | |
| Q3 2020 | -6.5% | -6.4% | +1.5% | |
| Q2 2020 | +4.6% | +2.5% | +0.9% | |
| Q1 2020 | -0.5% | -1.8% | -0.4% | |
| Q4 2019 | -6.4% | -7.3% | -15.1% | |
| Q3 2019 | +3.2% | +3.0% | +3.6% | |
| Q2 2019 | -10.0% | -11.8% | -18.6% | |
| Q1 2019 | +3.0% | +4.5% | +5.8% | |
| Q4 2018 | +5.2% | +8.5% | +9.7% | |
| Q3 2018 | -0.4% | -0.7% | +5.3% | |
| Q2 2018 | +4.3% | +5.1% | +7.5% | |
| Q1 2018 | -4.7% | -4.8% | -1.9% | |
| Q4 2017 | -5.1% | -6.2% | -8.7% | |
| Q3 2017 | +0.3% | +1.1% | +3.2% | |
| Q2 2017 | -0.7% | +1.4% | +2.3% | |
| Q1 2017 | -0.9% | -0.9% | -3.2% | |
| Q4 2016 | +1.1% | +2.5% | +10.2% | |
| Q3 2016 | -3.4% | -5.4% | -0.8% | |
| Q2 2016 | -5.4% | -5.0% | -7.0% | |
| Q1 2016 | +1.8% | — | — | |
| Q4 2015 | -1.6% | — | — | |
| Q3 2015 | +3.8% | — | — | |
| Q2 2015 | +4.1% | — | — | |
| Q1 2015 | -0.9% | — | — | |
| Q4 2014 | -2.6% | — | — | |
| Q3 2014 | +1.6% | — | — | |
| Q2 2014 | -2.8% | — | — | |
| Q1 2014 | -4.3% | — | — | |
| Q4 2013 | +1.5% | — | — | |
| Q3 2013 | +0.6% | — | — | |
| Q2 2013 | -1.0% | — | — | |
| Q1 2013 | -5.0% | — | — | |
| Q4 2012 | +2.5% | — | — | |
| Q3 2012 | -1.3% | — | — | |
| Q2 2012 | +0.9% | — | — | |
| Q1 2012 | +0.9% | — | — | |
| Q4 2011 | -0.6% | — | — | |
| Q3 2011 | +3.4% | — | — | |
| Q2 2011 | +4.8% | — | — | |
| Q1 2011 | +0.8% | — | — | |
| Q4 2010 | +1.5% | — | — | |
| Q3 2010 | -1.4% | — | — | |
| Q2 2010 | +0.5% | — | — | |
| Q1 2009 | -4.1% | — | — | |
| Q1 2010 | -1.1% | — | — | |
| Q4 2007 | +0.4% | — | — | |
| Q4 2009 | +0.4% | — | — | |
| Q3 2008 | +0.2% | — | — | |
| Q3 2009 | +0.2% | — | — | |
| Q4 2008 | +0.6% | — | — | |
| Q2 2008 | +0.6% | — | — | |
| Q2 2009 | +0.6% | — | — |
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