NASDAQ$XENE
Xenon Pharmaceuticals Inc · Q4 2023 earnings
Q4 2023 earnings · · Investor relations
Briefing
Xenon Pharmaceuticals reported financial results for Q4 2023 and provided a corporate update.
Xenon Pharmaceuticals reported a net loss of $44.7 million for the fourth quarter of 2023. The company's cash and cash equivalents and marketable securities were $930.9 million as of December 31, 2023, expected to fund operations into 2027. The company is advancing its XEN1101 program in epilepsy and major depressive disorder.
- XEN1101 Phase 3 epilepsy program continues to progress with X-TOLE2 and X-TOLE3 in focal onset seizures and X-ACKT in primary generalized tonic-clonic seizures; completion of patient enrollment in X-TOLE2 expected in late 2024 to early 2025.
- Planned “end-of-Phase 2” meeting with the FDA in April to support the initiation of XEN1101 Phase 3 program in major depressive disorder in the second half of the year.
- Strong financial position with approximately $930 million to fully support XEN1101 Phase 3 programs in epilepsy and major depressive disorder and expected cash runway into 2027.
- The company continues to evaluate other neurological indications that present a potential fit for XEN1101’s novel mechanism and product profile.
Headline financials
Revenue & EPS history
Xenon Pharmaceuticals · Revenue · Quarterly
$0
Forward guidance
Xenon anticipates patient enrollment in X-TOLE2 will be completed in late 2024 to early 2025. Xenon anticipates participating in an “end-of-Phase 2” meeting with the U.S. Food and Drug Administration in April to support the initiation of its late-stage XEN1101 clinical program in MDD, which will include three Phase 3 clinical trials, with the first Phase 3 study expected to initiate in the second half of 2024.
Tailwinds
- Completion of patient enrollment in X-TOLE2 expected in late 2024 to early 2025.
- Planned “end-of-Phase 2” meeting with the FDA in April to support the initiation of XEN1101 Phase 3 program in major depressive disorder in the second half of the year.
- Strong financial position with approximately $930 million to fully support XEN1101 Phase 3 programs in epilepsy and major depressive disorder and expected cash runway into 2027.
- Advancing XEN1101 in major depressive disorder with plans to conduct an end-of-Phase 2 meeting with the FDA in April, and we expect to initiate our Phase 3 program in the second half of this year.
- We also continue to evaluate other neurological indications that present a potential fit for XEN1101’s novel mechanism and product profile.
Headwinds
- Clinical trials may not demonstrate safety and efficacy of any of our or our collaborators’ product candidates.
- Promising results from pre-clinical development activities or early clinical trial results may not be replicated in later clinical trials.
- Our assumptions regarding our planned expenditures and sufficiency of our cash to fund operations may be incorrect.
- Any of our or our collaborators’ product candidates, including XEN1101, may fail in development, may not receive required regulatory approvals, or may be delayed to a point where they are not commercially viable.
- Regulatory agencies may impose additional requirements or delay the initiation of clinical trials.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2023
-1.2%
Avg return
Earnings day
-1.4%
Avg return
5 days after
+0.8%
Avg return
30 days after
39%
19 / 49 earnings
Positive
+15.8%
Q2 2018
Best reaction
-17.5%
Q3 2017
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | -4.5% | -6.1% | -11.8% | |
| Q4 2025 | -3.7% | -4.2% | +21.3% | |
| Q3 2025 | -4.9% | -7.0% | +8.5% | |
| Q2 2025 | +5.5% | +12.1% | +9.1% | |
| Q1 2025 | +2.3% | +0.7% | +5.7% | |
| Q4 2024 | -3.4% | -3.0% | -10.6% | |
| Q3 2024 | -4.8% | -9.6% | -10.5% | |
| Q1 2024 | -5.6% | -5.5% | -12.2% | |
| Q4 2023 | -2.1% | -3.8% | -10.0% | |
| Q3 2023 | -5.6% | -6.6% | +20.6% | |
| Q2 2023 | +8.6% | +6.2% | +7.9% | |
| Q1 2023 | -3.2% | -5.5% | +0.0% | |
| Q4 2022 | -5.3% | -5.9% | -9.3% | |
| Q3 2022 | -4.9% | -1.0% | +5.1% | |
| Q2 2022 | +0.1% | -4.4% | -3.3% | |
| Q1 2022 | +5.9% | +17.1% | +16.7% | |
| Q4 2021 | +3.3% | -4.6% | -3.6% | |
| Q3 2021 | -10.1% | -10.1% | -26.7% | |
| Q2 2021 | +6.3% | +5.6% | +3.9% | |
| Q1 2021 | -4.0% | -4.5% | +4.6% | |
| Q4 2020 | +8.2% | +6.6% | -4.2% | |
| Q3 2020 | -2.3% | +1.1% | -0.4% | |
| Q2 2020 | -2.1% | -3.6% | -1.9% | |
| Q1 2020 | +4.3% | -3.6% | -9.4% | |
| Q4 2019 | -9.3% | -18.7% | -10.3% | |
| Q3 2019 | +0.9% | -0.2% | +53.9% | |
| Q2 2019 | +0.6% | +4.0% | +10.2% | |
| Q1 2019 | -4.6% | -6.6% | +8.7% | |
| Q4 2018 | +7.3% | +6.3% | +18.8% | |
| Q3 2018 | -5.7% | -9.7% | -29.4% | |
| Q2 2018 | +15.8% | +23.7% | +38.4% | |
| Q1 2018 | +0.0% | -1.7% | +5.0% | |
| Q4 2017 | +6.2% | +17.3% | +22.2% | |
| Q3 2017 | -17.5% | -22.2% | -25.4% | |
| Q2 2017 | -4.8% | -7.9% | +1.6% | |
| Q1 2017 | -2.4% | -1.2% | -7.1% | |
| Q4 2016 | +0.0% | +0.0% | -54.2% | |
| Q3 2016 | -2.5% | -1.3% | -0.6% | |
| Q2 2016 | +1.5% | +3.6% | +9.6% | |
| Q1 2016 | +0.7% | — | — | |
| Q4 2015 | -1.1% | — | — | |
| Q3 2015 | -1.7% | — | — | |
| Q2 2015 | -6.0% | — | — | |
| Q1 2015 | +0.7% | — | — | |
| Q4 2012 | +6.1% | — | — | |
| Q3 2014 | +6.1% | — | — | |
| Q4 2014 | -5.5% | — | — | |
| Q3 2013 | -9.7% | — | — | |
| Q4 2013 | -9.7% | — | — | |
| Q1 2014 | — | — | — | |
| Q2 2013 | — | — | — | |
| Q1 2013 | — | — | — | |
| Q3 2012 | — | — | — |
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