NASDAQ$TSHA
Taysha Gene Therapies Inc · Q4 2024 earnings
Q4 2024 earnings · · Before market open · Investor relations
Briefing
Taysha Gene Therapies reported its full-year 2024 financial results, highlighting progress in its TSHA-102 clinical program and providing a corporate update.
Taysha Gene Therapies reported a net loss of $89.3 million for the full year ended December 31, 2024, an improvement from the $111.6 million net loss in the prior year. The company's TSHA-102 clinical program for Rett syndrome showed continued progress, with high and low doses being generally well tolerated across all treated patients. Research and development expenses increased to $66.0 million, driven by manufacturing and clinical trial activities, while general and administrative expenses decreased slightly.
- TSHA-102 continues to be generally well tolerated across all pediatric, adolescent, and adult patients in both REVEAL trials, with no treatment-related SAEs or DLTs.
- Dosing of all 10 patients in Part A of both REVEAL trials has been completed, and the maturing dataset supports advancement toward a pivotal Part B trial.
- Productive ongoing discussions with the FDA are solidifying the regulatory pathway for TSHA-102, with an update on pivotal trial design expected in H1 2025.
- Clinical data from cohort two (high dose) and cohort one (low dose) of both REVEAL trials are expected in H1 2025.
Headline financials
Revenue & EPS history
Taysha Gene Therapies · Revenue · Quarterly
$8.33M
Forward guidance
Taysha Gene Therapies anticipates providing updates on the pivotal trial design for TSHA-102 and clinical data from Part A of the REVEAL trials in the first half of 2025. The company expects its current cash resources to support planned operating expenses and capital requirements into the fourth quarter of 2026.
Tailwinds
- Update on pivotal trial design for TSHA-102 expected in H1 2025.
- Safety and efficacy data from REVEAL Adolescent and Adult Trial (cohort two high dose; n=3 and cohort one low dose; n=2) expected in H1 2025.
- Safety and efficacy data from REVEAL Pediatric Trial (cohort two high dose; n=3 and cohort one low dose; n=2) expected in H1 2025.
- Current cash resources are expected to support planned operating expenses and capital requirements into Q4 2026.
- Continued confidence in TSHA-102's potential to provide meaningful therapeutic benefit to a broad population of patients with Rett syndrome.
Headwinds
- No specific negative forward guidance was explicitly stated in the provided text.
- Reliance on future clinical trial results and regulatory approvals for TSHA-102.
- Potential for unforeseen risks and uncertainties that could cause actual results to differ materially from expectations.
- The company's ability to secure additional funding if needed beyond Q4 2026 is not explicitly addressed.
- The success of TSHA-102 is critical, as it is the lead clinical program.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports · overlaid with Q4 2024
+10.9%
Avg return
Earnings day
+11.7%
Avg return
5 days after
+18.2%
Avg return
30 days after
52%
12 / 23 earnings
Positive
+195.0%
Q2 2023
Best reaction
-16.0%
Q2 2022
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q4 2025 | -3.5% | -6.3% | — | |
| Q1 2026 | +0.6% | -1.6% | -20.9% | |
| Q3 2025 | -5.9% | -8.9% | +18.3% | |
| Q2 2025 | +5.4% | +6.5% | +17.4% | |
| Q1 2025 | +8.1% | +23.6% | +7.2% | |
| Q4 2024 | -4.7% | -4.7% | +13.5% | |
| Q3 2024 | -5.0% | -4.6% | -13.4% | |
| Q2 2024 | +9.1% | +7.7% | +11.0% | |
| Q1 2024 | +29.6% | +28.7% | +73.7% | |
| Q4 2023 | +39.0% | +52.6% | +13.1% | |
| Q3 2023 | +26.3% | +27.8% | +16.5% | |
| Q2 2023 | +195.0% | +159.8% | +312.7% | |
| Q1 2023 | -10.5% | -7.7% | +14.7% | |
| Q4 2022 | -6.5% | +14.8% | -3.9% | |
| Q3 2022 | -5.5% | +9.0% | +2.5% | |
| Q2 2022 | -16.0% | -16.4% | -29.9% | |
| Q1 2022 | -4.1% | -19.5% | -12.5% | |
| Q4 2021 | +3.1% | +8.5% | -40.5% | |
| Q3 2021 | +0.2% | -3.1% | -9.3% | |
| Q2 2021 | +0.7% | -2.6% | +20.1% | |
| Q1 2021 | -0.7% | +2.0% | +19.9% | |
| Q4 2020 | -7.2% | -0.2% | -19.9% | |
| Q3 2020 | +2.2% | +4.0% | +10.3% |
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