NASDAQ$SNDX

Syndax Pharmaceuticals Inc · Q1 2025 earnings

Q1 2025 earnings · · After market close · Investor relations

Briefing

Syndax Pharmaceuticals reported Q1 2025, revenue of $20M, a net loss of $84.8M.

For Q1 2025, Syndax Pharmaceuticals reported revenue of $20M, a net loss of $84.8M. The filing highlights segment performance, liquidity, and management commentary on the period.

  • Revenue $20M.
  • Net loss $84.8M.
  • Syndax Pharmaceuticals discusses capital allocation and near-term priorities in MD&A.

Headline financials

Total Revenue

$19.9M

Previous: $0.00
EPS (adj)

-$0.98

Previous: -$0.85-15.3%
Research and development

$61.6M

Previous: $56.5M+9.1%
Selling, general and administrative

$41M

Previous: $23M+78.2%
Total Operating Expenses

$104M

Previous: $79.5M+30.5%
Capital Expenditures

$0.00

Previous: $0.00
Net Income

-$84.8M

Previous: -$72.4M-17.2%
Operating Income

-$83.8M

Previous: -$79.5M-5.3%
Gross Profit

$19.2M

Previous: $0.00
R&D Expense

$61.6M

Previous: $56.5M+9.1%

Revenue & EPS history

Syndax · Revenue · Quarterly

$19.9M

Q1 2025
Beat estimate in 2 of 9 quarters(22%)
ActualEstimate

Revenue by segment

Syndax · $38M total across 2 segments · Q2 2025

  • Revuforj (product)
    $28.6M—
  • Niktimvo (collaboration)
    $9.36M—

Forward guidance

Management discusses operating priorities, capital allocation, and sector risks in the quarterly filing.

Tailwinds

  • Headline results and segment trends anchor the quarter.
  • Liquidity and balance-sheet capacity support operations.
  • Strategic initiatives outlined in MD&A.

Headwinds

  • Macro, rates, or input costs may pressure margins.
  • One-time items affect year-over-year comparability.
  • Execution risk on growth or restructuring plans.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 19 quarterly earnings reports · overlaid with Q1 2025

Historical avgQ1 2025

+1.6%

Avg return

Earnings day

+0.9%

Avg return

5 days after

+3.5%

Avg return

30 days after

60%

24 / 40 earnings

Positive

+15.1%

Q4 2019

Best reaction

-21.6%

Q1 2025

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q2 2025———
Q1 2026+3.9%-2.6%-5.2%
Q4 2025+5.1%+4.6%+13.6%
Q3 2025+11.6%+9.3%+43.5%
Q1 2025-21.6%-21.1%-17.8%
Q4 2024-7.1%-13.3%-19.5%
Q3 2024+12.7%+15.2%-11.3%
Q2 2024-7.3%-12.3%-9.5%
Q1 2024-5.2%-9.5%-15.9%
Q4 2023-2.1%-2.7%-2.4%
Q3 2023+6.3%+5.0%+19.0%
Q2 2023-3.5%-10.9%-4.5%
Q1 2023+7.8%+5.0%+3.8%
Q4 2022+1.6%-0.1%-15.6%
Q3 2022-2.0%-2.2%+9.5%
Q2 2022+0.5%+0.5%-2.4%
Q1 2022-5.8%-12.3%+10.1%
Q4 2021+3.3%-2.2%+11.5%
Q3 2021+2.1%-0.9%+5.9%
Q2 2021+7.0%+11.2%+23.9%
Q1 2021+14.6%+18.5%+21.5%
Q4 2020+0.4%-2.8%-5.3%
Q3 2020+8.8%+20.4%+30.9%
Q2 2020+6.5%-0.9%+0.7%
Q1 2020-1.8%+3.2%-8.0%
Q4 2019+15.1%+22.8%-0.6%
Q3 2019-0.3%+0.3%+24.5%
Q2 2019+10.6%+8.6%-3.0%
Q1 2019+9.1%+6.1%+3.9%
Q4 2018-13.5%-11.1%-4.2%
Q3 2018+2.1%+5.9%-3.5%
Q2 2018+12.0%+6.7%+8.8%
Q1 2018+9.9%+1.5%-25.5%
Q4 2017-1.5%-0.6%+47.9%
Q3 2017-11.7%-10.1%-28.4%
Q2 2017-5.7%-1.5%+8.0%
Q1 2017-7.0%+4.7%+26.7%
Q4 2016+5.0%+1.0%+18.0%
Q3 2016+0.9%-4.9%-17.1%
Q2 2016+5.6%+5.5%+3.1%
Q1 2016-2.1%——
Q4 2015———
Q3 2015———
Q2 2015———
Q1 2015———
Q4 2014———
Q3 2014———
Q2 2014———
Q1 2014———
Q4 2013———
Q3 2013———
Q2 2013———
Q1 2013———

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