NASDAQ$LYRA

Lyra Therapeutics Inc · Q2 2022 earnings

Q2 2022 earnings · · Investor relations

Briefing

Lyra Therapeutics reported financial results for the second quarter ended June 30, 2022, and highlighted recent accomplishments.

Lyra Therapeutics reported a net loss of $14.5 million for the quarter ended June 30, 2022. The company's cash and cash equivalents as of June 30, 2022 were $120.7 million, which is expected to fund planned operations through mid-2024. Enrollment is ongoing for the ENLIGHTEN I Phase 3 trial, and the first patient was treated in Australia in the Part 1/non-randomized portion of the BEACON Phase 2 trial.

  • Reported continued progress for ongoing clinical programs designed to address the full spectrum of CRS patients.
  • Pivotal ENLIGHTEN Phase 3 program for LYR-210 is actively enrolling patients with chronic rhinosinusitis and surgically naïve anatomy
  • BEACON Phase 2 trial for LYR-220 is continuing enrollment of CRS patients with recurrent CRS despite surgical intervention.
  • In April 2022, secured $96.3 million in net proceeds in an at-the-market, private placement of common stock that is expected to support two pivotal data readouts; cash runway extended until mid-2024

Headline financials

Total Revenue

$407K

No prior period
EPS (adj)

-$0.43

Previous: -$0.85+49.4%
R&D expenses

$10.8M

No prior period
G&A expenses

$4.13M

No prior period
Capital Expenditures

-$107K

Previous: $625K-117.1%
Free Cash Flow

-$14.6M

Previous: $2.76M-629.4%
Net Income

-$14.5M

Previous: -$11M-31.7%
Operating Income

-$14.5M

Previous: -$11.1M-31.2%
Gross Profit

$107K

No prior period
Cash & Equivalents

$121M

Previous: $69M+74.8%
Total Assets

$130M

Previous: $76.3M+70.4%
Stock-Based Comp

$1.11M

Previous: $656K+68.8%

Revenue & EPS history

Lyra · Revenue · Quarterly

$407K

Q2 2022
Beat estimate in 8 of 15 quarters(53%)
ActualEstimate

Revenue by segment

Lyra · $407K total across 1 segment · Q2 2022

  • Collaboration revenue
    $407K

Forward guidance

The company expects its cash and cash equivalents balance to be sufficient to fund its planned operations through mid-2024. Enrollment in the pivotal ENLIGHTEN I Phase 3 trial is ongoing, while the ENLIGHTEN II Phase 3 trial is actively screening patients and we expect to enroll the first patient in the third quarter. Part 2/randomized portion of the BEACON Phase 2 trial is anticipated to commence in the U.S. in the third quarter.

Tailwinds

  • Cash and cash equivalents expected to fund operations through mid-2024
  • Enrollment in ENLIGHTEN I Phase 3 trial is ongoing
  • ENLIGHTEN II Phase 3 trial is actively screening patients
  • First patient expected to enroll in ENLIGHTEN II in Q3
  • Part 2 of BEACON Phase 2 trial anticipated to commence in the U.S. in Q3

Headwinds

  • Incurred significant losses since inception
  • Expects to incur additional losses for the foreseeable future
  • Needs additional funding, which may not be available
  • Limited operating history
  • Has no approved products

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q2 2022

Historical avgQ2 2022

-1.6%

Avg return

Earnings day

-3.1%

Avg return

5 days after

-1.7%

Avg return

30 days after

29%

7 / 24 earnings

Positive

+11.0%

Q1 2024

Best reaction

-25.4%

Q3 2024

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q4 2025+0.0%+0.1%+52.2%
Q3 2025-1.0%-5.9%-6.3%
Q2 2025+9.5%+8.3%-6.8%
Q1 2025-6.3%-17.3%+102.9%
Q4 2024-4.1%-14.8%-39.2%
Q3 2024-25.4%-35.8%-23.8%
Q2 2024-3.3%+4.0%-6.6%
Q1 2024+11.0%-14.8%-93.0%
Q4 2023+2.8%+1.0%-14.5%
Q3 2023+0.0%+2.4%+33.4%
Q2 2023+5.4%+13.8%+20.8%
Q1 2023-6.8%-2.1%+3.6%
Q4 2022+6.1%+13.8%+22.4%
Q3 2022-17.9%-20.3%-35.8%
Q2 2022-1.7%+0.6%-5.2%
Q1 2022+7.1%+7.7%+18.1%
Q4 2021-4.0%-5.8%+22.8%
Q3 2021-1.0%-0.4%-32.9%
Q2 2021-3.9%-0.4%+17.6%
Q1 2021-1.0%-5.6%+11.9%
Q4 2020-4.8%-2.2%-20.9%
Q3 2020+1.0%-1.8%-13.3%
Q2 2020-0.9%+0.9%-17.8%
Q1 2020-0.5%+0.1%-31.6%
Q3 2019
Q2 2019
Q1 2019

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