NASDAQ$AXSM
Axsome Therapeutics Inc · Q4 2021 earnings
Q4 2021 earnings · · Investor relations
Briefing
Axsome reported financial results for Q4 and full year 2021 and provided a business update.
Axsome Therapeutics reported a net loss of $34.0 million for the fourth quarter of 2021, compared to a net loss of $29.2 million for the same period in 2020. The company's R&D expenses were $13.8 million, and G&A expenses were $18.8 million. The company anticipates potential launches for AXS-05 and AXS-07.
- FDA review of NDA for AXS-05 in depression is progressing.
- PDUFA date for NDA for AXS-07 in the acute treatment of migraine is approaching on April 30, 2022.
- Topline results from Phase 3 trials of AXS-12 in narcolepsy and AXS-05 in Alzheimer’s disease agitation are anticipated in 2023.
- The AXS-05 field force team build is essentially complete with all signed offers contingent upon approval.
Headline financials
Revenue & EPS history
Axsome · Revenue · Quarterly
$191M
Revenue by segment
Axsome · $57.8M total across 2 segments · Q3 2023
- AUVELITY$37.7M—65.2%
- SUNOSI$20.1M+19.6%34.8%
Forward guidance
Axsome believes its current cash, along with the remaining committed capital, is sufficient to fund anticipated operations into 2024 and expects that operating expenses will increase year over year as it continues to build out the commercial function and further advance its pipeline.
Tailwinds
- Current cash is sufficient to fund operations into 2024.
- Remaining committed capital from the term loan facility available.
- Potential commercial launch of AXS-05 in MDD.
- Potential commercial launch of AXS-07 in migraine.
- Ongoing build-out of the commercial function.
Headwinds
- Operating expenses are expected to increase year over year.
- Continued advancement of the pipeline will increase expenses.
- Uncertainties regarding regulatory approvals.
- Potential delays in clinical trials.
- Market acceptance of product candidates is not guaranteed.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2021
-1.0%
Avg return
Earnings day
-2.9%
Avg return
5 days after
+1.7%
Avg return
30 days after
51%
21 / 41 earnings
Positive
+12.9%
Q1 2022
Best reaction
-53.5%
Q2 2021
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +8.1% | +5.3% | +13.0% | |
| Q4 2025 | -4.7% | -10.8% | -11.9% | |
| Q3 2025 | +1.9% | +2.3% | +9.5% | |
| Q1 2025 | +3.7% | -4.0% | -3.6% | |
| Q4 2024 | -2.3% | +5.0% | -3.7% | |
| Q3 2024 | +7.5% | +2.4% | +3.7% | |
| Q2 2024 | +1.3% | -1.6% | +13.2% | |
| Q1 2024 | +2.9% | -3.1% | -0.9% | |
| Q4 2023 | -11.5% | -14.9% | -12.9% | |
| Q3 2023 | -3.1% | -11.9% | +6.5% | |
| Q2 2023 | -1.5% | -5.5% | +10.7% | |
| Q1 2023 | +4.1% | +7.1% | +2.4% | |
| Q4 2022 | +11.7% | +6.9% | +2.3% | |
| Q3 2022 | +11.2% | +3.4% | +36.9% | |
| Q2 2022 | +11.7% | +6.8% | +41.3% | |
| Q1 2022 | +12.9% | -6.1% | -24.3% | |
| Q4 2021 | +11.9% | +6.4% | +47.2% | |
| Q3 2021 | +1.4% | -2.3% | -12.6% | |
| Q2 2021 | -53.5% | -55.3% | -48.9% | |
| Q1 2021 | +0.1% | +2.6% | +11.5% | |
| Q4 2020 | +3.6% | -3.5% | -15.9% | |
| Q3 2020 | -9.7% | -6.3% | +7.1% | |
| Q2 2020 | -0.6% | +1.2% | -7.3% | |
| Q1 2020 | -2.8% | -7.9% | -15.7% | |
| Q4 2019 | -16.8% | -38.7% | -23.8% | |
| Q3 2019 | -1.2% | -4.6% | +76.4% | |
| Q2 2019 | +2.2% | +11.0% | -0.5% | |
| Q1 2019 | +7.2% | +10.7% | +12.2% | |
| Q4 2018 | +4.6% | +24.3% | +29.2% | |
| Q3 2018 | -15.8% | -28.1% | -24.7% | |
| Q2 2018 | -1.9% | -8.6% | +27.6% | |
| Q1 2018 | +1.5% | +3.0% | +4.5% | |
| Q4 2017 | +2.6% | +6.5% | -8.4% | |
| Q3 2017 | -4.1% | +1.0% | -0.5% | |
| Q2 2017 | -5.0% | -12.6% | -19.3% | |
| Q1 2017 | -1.2% | -1.2% | -4.8% | |
| Q4 2016 | -4.1% | +6.1% | -27.6% | |
| Q3 2016 | +0.7% | +4.1% | -17.8% | |
| Q2 2016 | -1.4% | -3.4% | -1.6% | |
| Q1 2016 | -1.4% | -3.4% | -1.6% | |
| Q4 2015 | -10.0% | — | — | |
| Q3 2015 | — | — | — | |
| Q2 2015 | — | — | — | |
| Q1 2015 | — | — | — | |
| Q4 2014 | — | — | — | |
| Q3 2014 | — | — | — | |
| Q2 2014 | — | — | — | |
| Q1 2014 | — | — | — |
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