NASDAQ$AMLX
Amylyx Pharmaceuticals Inc · Q4 2025 earnings
Q4 2025 earnings · · Before market open · Investor relations
Briefing
Amylyx Pharmaceuticals reported Q4 2025, net loss of $33M, diluted EPS of $-0.30.
For Q4 2025, Amylyx Pharmaceuticals reported a net loss of $33M, diluted EPS was $-0.30. Management discusses segment performance, capital allocation, and macro risks in the quarterly filing.
- Net loss $33M.
- Diluted EPS $-0.30.
- Amylyx Pharmaceuticals MD&A covers liquidity, capital, and operating priorities.
Headline financials
Revenue & EPS history
Amylyx · Revenue · Quarterly
$0
Forward guidance
Clinical-stage outlook focuses on trial readouts, cash runway, and regulatory milestones rather than near-term product revenue.
Tailwinds
- Pipeline catalysts and trial enrollment progress.
- Cash runway supports operating plan.
- Partnerships may provide non-dilutive funding.
Headwinds
- Clinical and regulatory risk.
- R&D spend and financing needs.
- Competitive therapies in development.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 18 quarterly earnings reports · overlaid with Q4 2025
+0.3%
Avg return
Earnings day
+2.5%
Avg return
5 days after
+7.4%
Avg return
30 days after
44%
8 / 18 earnings
Positive
+23.4%
Q4 2021
Best reaction
-30.7%
Q3 2023
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q4 2025 | -7.6% | -9.5% | -2.3% | |
| Q3 2025 | -5.9% | -4.2% | +7.3% | |
| Q1 2025 | -6.0% | -7.8% | +9.4% | |
| Q4 2024 | +0.3% | +29.0% | +17.0% | |
| Q3 2024 | +7.7% | +0.3% | -17.4% | |
| Q2 2024 | +1.1% | +5.9% | +26.1% | |
| Q1 2024 | -8.8% | -3.1% | -8.3% | |
| Q4 2023 | +15.3% | +24.1% | -82.1% | |
| Q3 2023 | -30.7% | -30.4% | -22.2% | |
| Q2 2023 | +0.5% | -2.3% | -4.5% | |
| Q1 2023 | -4.4% | -6.1% | -11.9% | |
| Q4 2022 | +11.2% | -1.2% | -3.9% | |
| Q3 2022 | -1.8% | +2.4% | +3.0% | |
| Q3 2021 | -1.8% | +2.4% | +3.0% | |
| Q2 2021 | -5.5% | -5.7% | +12.7% | |
| Q2 2022 | -5.5% | -5.7% | +12.7% | |
| Q4 2021 | +23.4% | +28.2% | +97.5% | |
| Q1 2022 | +23.4% | +28.2% | +97.5% | |
| Q1 2021 | — | — | — | |
| Q4 2020 | — | — | — |
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