NASDAQ$AMLX

Amylyx Pharmaceuticals Inc · Q1 2022 earnings

Q1 2022 earnings · · Investor relations

Briefing

Amylyx reported financial results for the quarter ended March 31, 2022.

Amylyx Pharmaceuticals reported a net loss of $47.8 million for the first quarter of 2022. The company is focused on commercial launch readiness to support AMX0035 for ALS treatment and engaging with regulators for potential approvals.

  • Regulatory applications for AMX0035 are under review in the U.S., Canada, and Europe.
  • New analyses from the CENTAUR trial demonstrated a significant survival benefit of AMX0035.
  • Safety and tolerability data from CENTAUR and PEGASUS trials were presented at the 2022 AAN Annual Meeting.
  • An Expanded Access Program (EAP) for AMX0035 was launched in the U.S. for eligible people living with ALS.

Headline financials

EPS (adj)

-$0.93

Previous: -$0.32-194.3%
R&D Expenses

$21.5M

Previous: $6.86M+212.7%
SG&A Expenses

$26.4M

Previous: $6M+338.9%
Capital Expenditures

$342K

No prior period
Free Cash Flow

-$41M

No prior period
Net Income

-$47.8M

Previous: -$14.5M-229.5%
Operating Income

-$47.8M

Previous: -$12.9M-271.6%
Cash & Equivalents

$255M

No prior period
Total Assets

$274M

No prior period
Stock-Based Comp

$4.39M

No prior period

Revenue & EPS history

Amylyx · Revenue · Quarterly

$0

Q4 2025-100%vs Q4 2024
Beat estimate in 3 of 8 quarters(38%)
ActualEstimate

Forward guidance

The company is focused on advancing AMX0035 through regulatory processes and preparing for potential commercial launch.

Tailwinds

  • Potential regulatory approval of AMX0035 in the U.S., Canada, and Europe.
  • Ongoing Phase 3 PHOENIX clinical trial evaluating AMX0035.
  • Commitment to bringing new and effective treatments to the ALS community.
  • Positive safety and efficacy data supporting AMX0035.
  • Expanded Access Program providing access to AMX0035 for eligible patients.

Headwinds

  • Uncertainty regarding the timing of FDA review and potential approval of AMX0035.
  • Dependence on the success of AMX0035.
  • Risks associated with clinical trials and regulatory processes.
  • Potential impact of the COVID-19 pandemic on operations.
  • Competition from other companies developing treatments for ALS.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 18 quarterly earnings reports · overlaid with Q1 2022

Historical avgQ1 2022

+0.3%

Avg return

Earnings day

+2.5%

Avg return

5 days after

+7.4%

Avg return

30 days after

44%

8 / 18 earnings

Positive

+23.4%

Q4 2021

Best reaction

-30.7%

Q3 2023

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q4 2025-7.6%-9.5%-2.3%
Q3 2025-5.9%-4.2%+7.3%
Q1 2025-6.0%-7.8%+9.4%
Q4 2024+0.3%+29.0%+17.0%
Q3 2024+7.7%+0.3%-17.4%
Q2 2024+1.1%+5.9%+26.1%
Q1 2024-8.8%-3.1%-8.3%
Q4 2023+15.3%+24.1%-82.1%
Q3 2023-30.7%-30.4%-22.2%
Q2 2023+0.5%-2.3%-4.5%
Q1 2023-4.4%-6.1%-11.9%
Q4 2022+11.2%-1.2%-3.9%
Q3 2022-1.8%+2.4%+3.0%
Q3 2021-1.8%+2.4%+3.0%
Q2 2021-5.5%-5.7%+12.7%
Q2 2022-5.5%-5.7%+12.7%
Q4 2021+23.4%+28.2%+97.5%
Q1 2022+23.4%+28.2%+97.5%
Q1 2021
Q4 2020

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