NASDAQ$AMLX

Amylyx Pharmaceuticals Inc · Q4 2023 earnings

Q4 2023 earnings · · Investor relations

Briefing

Amylyx reported positive net income and revenue growth, driven by increased sales of RELYVRIO and ALBRIOZA.

Amylyx Pharmaceuticals reported Q4 2023 financial results, highlighted by $108.4 million in net product revenue and a net income of $4.7 million. The company's full-year revenue reached $380.8 million, with a net income of $49.3 million. Amylyx is progressing its clinical trials and expanding the commercialization of its ALS treatments.

  • Net product revenue for Q4 2023 was $108.4 million.
  • Net income for Q4 2023 was $4.7 million.
  • Cash, cash equivalents, and short-term investments totaled $371.4 million as of December 31, 2023.
  • Amylyx is advancing clinical trials for AMX0035 in PSP and Wolfram syndrome.

Headline financials

Total Revenue

$108M

Previous: $21.9M+395.5%
EPS (adj)

$0.07

Previous: -$0.65+110.8%
Capital Expenditures

$356K

Previous: $620K-42.6%
Net Income

$4.7M

Previous: -$42.7M+111.0%
Operating Income

$1.93M

Previous: -$44.6M+104.3%
Gross Profit

$99.1M

Previous: $19.1M+419.8%
R&D Expense

$44.9M

No prior period
Stock-Based Comp

$9.53M

Previous: $6.09M+56.5%

Revenue & EPS history

Amylyx · Revenue · Quarterly

$108M

Q4 2023+395.5%vs Q4 2022
Beat estimate in 3 of 8 quarters(38%)
ActualEstimate

Forward guidance

Amylyx anticipates sharing topline data from its Phase 3 PHOENIX trial during or before the second quarter of 2024 and continues to progress its R&D programs.

Tailwinds

  • Topline data from Phase 3 PHOENIX trial expected during or before Q2 2024.
  • Advancing AMX0035 in Progressive Supranuclear Palsy (PSP) through Phase 3 ORION trial.
  • Data from Phase 2 HELIOS trial in Wolfram syndrome expected in 2024.
  • AMX0114, an antisense oligonucleotide, is entering the clinic.
  • Working on a new taste-masked formulation of RELYVRIO that may allow for new intellectual property.

Headwinds

  • The Phase 3 ORION trial topline results are not anticipated until 2025 or 2026.
  • Potential risks associated with disorders that interfere with bile acid circulation.
  • Potential risks associated with high sodium intake from RELYVRIO.
  • Uncertainties regarding the success, cost, and timing of program development activities.
  • Dependence on successful commercialization of RELYVRIO and ALBRIOZA.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 18 quarterly earnings reports · overlaid with Q4 2023

Historical avgQ4 2023

+0.3%

Avg return

Earnings day

+2.5%

Avg return

5 days after

+7.4%

Avg return

30 days after

44%

8 / 18 earnings

Positive

+23.4%

Q4 2021

Best reaction

-30.7%

Q3 2023

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q4 2025-7.6%-9.5%-2.3%
Q3 2025-5.9%-4.2%+7.3%
Q1 2025-6.0%-7.8%+9.4%
Q4 2024+0.3%+29.0%+17.0%
Q3 2024+7.7%+0.3%-17.4%
Q2 2024+1.1%+5.9%+26.1%
Q1 2024-8.8%-3.1%-8.3%
Q4 2023+15.3%+24.1%-82.1%
Q3 2023-30.7%-30.4%-22.2%
Q2 2023+0.5%-2.3%-4.5%
Q1 2023-4.4%-6.1%-11.9%
Q4 2022+11.2%-1.2%-3.9%
Q3 2022-1.8%+2.4%+3.0%
Q3 2021-1.8%+2.4%+3.0%
Q2 2021-5.5%-5.7%+12.7%
Q2 2022-5.5%-5.7%+12.7%
Q4 2021+23.4%+28.2%+97.5%
Q1 2022+23.4%+28.2%+97.5%
Q1 2021
Q4 2020

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