NASDAQ$TYRA

Tyra Biosciences Inc · Q4 2025 earnings

Q4 2025 earnings · · After market close · Investor relations

Briefing

TYRA reported Q4 2025, a net loss of $33.8M.

For Q4 2025, TYRA reported a net loss of $33.8M. Management discusses segment performance, capital allocation, and macro risks in the quarterly filing.

  • Net loss $33.8M.
  • TYRA MD&A covers liquidity, operating priorities, and sector risks.
  • TYRA MD&A covers liquidity, operating priorities, and sector risks.

Headline financials

Total Revenue

$0.00

Previous: $0.00
EPS (adj)

-$0.57

Previous: -$0.43-32.6%
Research and Development Expense

$28.2M

Previous: $22.2M+27.1%
General and Administrative Expense

$8.33M

Previous: $7.56M+10.1%
Total Operating Expenses

$36.5M

Previous: $29.7M+22.8%
Interest and Other Income, Net

$2.68M

Previous: $4.17M-35.7%
Unrealized Gain (Loss) on Marketable Securities

-$49K

Previous: -$982K+95.0%
Comprehensive Loss

-$33.9M

Previous: -$26.6M-27.6%
Weighted Average Shares Outstanding

59.8M

Previous: 59.1M+1.3%
Net Income

-$33.8M

Previous: -$25.6M-32.0%
Operating Income

-$36.5M

Previous: -$29.7M-22.8%

Revenue & EPS history

Tyra Biosciences · Revenue · Quarterly

$0

Q4 2025

Forward guidance

The quarterly filing discusses operating priorities, capital returns, and sector risks.

Tailwinds

  • MD&A highlights liquidity and core business trends.
  • Segment commentary supports the earnings narrative.

Headwinds

  • Macro or input-cost pressure may affect margins.
  • One-time items can affect YoY comparability.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 18 quarterly earnings reports · overlaid with Q4 2025

Historical avgQ4 2025

+2.0%

Avg return

Earnings day

+3.0%

Avg return

5 days after

-0.8%

Avg return

30 days after

50%

9 / 18 earnings

Positive

+29.8%

Q3 2021

Best reaction

-11.5%

Q4 2021

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q4 2025+1.5%+7.7%+21.8%
Q3 2025+0.3%+8.4%+50.6%
Q2 2025+0.4%-4.3%+17.0%
Q1 2025-3.1%-4.0%+2.3%
Q4 2024-0.8%-10.5%+3.9%
Q3 2024-5.9%-6.9%-8.1%
Q1 2024-3.8%+3.1%+9.7%
Q4 2023+7.0%+3.0%-9.7%
Q3 2023-6.3%-8.1%+2.5%
Q2 2023+0.9%+1.6%-3.4%
Q1 2023-3.3%+7.0%+13.1%
Q4 2022-3.3%+0.0%-9.8%
Q3 2022-7.1%+12.9%-3.1%
Q2 2022+11.1%+14.7%-24.0%
Q1 2022+0.1%-5.9%-17.8%
Q4 2021-11.5%-5.3%-6.4%
Q2 2021+29.8%+20.3%-26.6%
Q3 2021+29.8%+20.3%-26.6%
Q1 2021
Q4 2020
Q3 2020
Q2 2020
Q1 2020

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