NASDAQ$PRAX
Praxis Precision Medicines I · Q1 2026 earnings
Q1 2026 earnings · · Before market open · Investor relations
Briefing
Praxis Precision Medicines reported Q1 2026 revenue of $0 with a net loss of $92.6M and diluted loss per share of $3.20.
For the quarter ended March 31, 2026, Praxis had no product or collaboration revenue and reported a net loss of $92.6 million versus $47.0 million a year ago. Diluted loss per share was $3.20 compared with $1.63. R&D expense increased materially as ulixacaltamide and other CNS programs advanced, and G&A rose with public-company and clinical costs.
- No revenue; net loss widened to $92.6M from $47.0M.
- Diluted loss per share was $3.20 on a larger share base.
- R&D spending accelerated on ulixacaltamide and pipeline programs.
- Cash and investments fund continued clinical development per MD&A.
- Company remains pre-commercial with CNS-focused candidates.
Headline financials
Revenue & EPS history
Praxis · Revenue · Quarterly
$0
Revenue by segment
Praxis · $500K total across 1 segment · Q3 2023
- Collaboration Revenue$500K—100.0%
Forward guidance
Praxis does not provide financial guidance in the 10-Q and expects significant losses until potential product approvals generate commercial revenue.
Tailwinds
- Clinical milestones for lead CNS programs continue to advance.
- Prior financings support ongoing trial execution.
Headwinds
- R&D-driven net loss more than doubled year over year.
- No near-term product revenue expected before regulatory milestones.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports · overlaid with Q1 2026
-0.3%
Avg return
Earnings day
+3.3%
Avg return
5 days after
-4.0%
Avg return
30 days after
57%
13 / 23 earnings
Positive
+22.3%
Q2 2022
Best reaction
-40.6%
Q4 2024
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +1.7% | -6.4% | -22.2% | |
| Q4 2025 | +0.5% | +4.2% | -9.3% | |
| Q3 2025 | -4.7% | -2.2% | +44.4% | |
| Q1 2025 | +0.2% | -3.5% | +16.3% | |
| Q4 2024 | -40.6% | -41.8% | -40.6% | |
| Q3 2024 | +3.6% | +16.6% | -4.0% | |
| Q2 2024 | -1.1% | +2.0% | +13.3% | |
| Q1 2024 | -5.9% | -6.9% | -15.8% | |
| Q4 2023 | +6.3% | +2.3% | -7.3% | |
| Q3 2023 | +1.4% | -0.6% | +21.6% | |
| Q2 2023 | +10.8% | +17.0% | +43.9% | |
| Q1 2023 | -2.8% | -1.9% | -7.7% | |
| Q4 2022 | -4.2% | -13.0% | -77.0% | |
| Q3 2022 | -12.5% | -11.2% | -13.3% | |
| Q2 2022 | +22.3% | +33.2% | -3.4% | |
| Q1 2022 | +14.0% | +28.1% | -77.7% | |
| Q4 2021 | -1.9% | -4.2% | -22.9% | |
| Q3 2021 | +2.4% | +2.0% | -17.1% | |
| Q2 2020 | +12.7% | +35.9% | +42.8% | |
| Q2 2021 | +12.7% | +35.9% | +42.8% | |
| Q1 2021 | -16.4% | -16.1% | -20.2% | |
| Q4 2020 | -6.8% | -11.5% | -34.0% | |
| Q3 2020 | +2.3% | +18.2% | +54.7% | |
| Q1 2020 | — | — | — | |
| Q4 2019 | — | — | — | |
| Q3 2019 | — | — | — | |
| Q2 2019 | — | — | — | |
| Q1 2019 | — | — | — |
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