NASDAQ$LYEL
Lyell Immunopharma Inc · Q1 2025 earnings
Q1 2025 earnings · · Before market open · Investor relations
Briefing
Lyell Immunopharma reported a reduced net loss and increased operating expenses in the first quarter of 2025, driven by personnel costs and strategic acquisitions.
Lyell Immunopharma reported a net loss of $52.2 million for the first quarter ended March 31, 2025, an improvement from a net loss of $60.7 million in the same period of 2024. The decrease in net loss was primarily due to the absence of impairment expenses recognized in the prior year, partially offset by lower interest income. The company's cash, cash equivalents, and marketable securities stood at $330.1 million, which is expected to support operations into 2027.
- Net loss decreased to $52.2 million in Q1 2025 from $60.7 million in Q1 2024, primarily due to the absence of impairment expenses.
- Research and development expenses remained stable at $43.4 million, with a slight increase due to personnel costs and severance related to facility closure.
- General and administrative expenses increased to $14.0 million, driven by higher headcount from acquisitions and severance expenses.
- Cash, cash equivalents, and marketable securities totaled $330.1 million, providing sufficient liquidity to fund operations through 2027.
Headline financials
Revenue & EPS history
Lyell Immunopharma · Revenue · Quarterly
$7
Forward guidance
Lyell Immunopharma anticipates significant progress in its clinical development, with plans to initiate pivotal trials for LYL314 in both third-line and second-line settings by early 2026, supported by its manufacturing capabilities and financial resources.
Tailwinds
- On track to initiate a pivotal trial for LYL314 in the third- or later-line setting by mid-2025.
- Expects to initiate a pivotal trial for LYL314 in the second-line setting by early 2026.
- LYL314 clinical supply is now manufactured at Lyell's LyFE Manufacturing Center, ensuring drug supply for ongoing and planned trials.
- Cash, cash equivalents, and marketable securities of $330.1 million are expected to support pipeline advancement through multiple clinical milestones into 2027.
- First IND for a fully-armed CAR T-cell product candidate with an undisclosed target for solid tumors is expected in 2026.
Headwinds
- The complexity of manufacturing cellular therapies could substantially increase costs and delay programs or limit supply.
- RMAT designation may not actually lead to faster development, regulatory review, or approval.
- Lyell's limited experience in enrolling and conducting clinical trials may pose challenges.
- Nonclinical profiles of product candidates or technology may not translate to clinical trials.
- Significant adverse events, toxicities, or other undesirable side effects could be associated with product candidates.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q1 2025
+1.5%
Avg return
Earnings day
-4.0%
Avg return
5 days after
+1.1%
Avg return
30 days after
73%
16 / 22 earnings
Positive
+20.3%
Q4 2024
Best reaction
-18.3%
Q3 2022
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +1.1% | -7.0% | -42.1% | |
| Q4 2025 | +2.5% | -19.0% | -9.6% | |
| Q3 2025 | -1.3% | +1.7% | +95.5% | |
| Q1 2025 | +4.6% | +2.0% | +21.1% | |
| Q4 2024 | +20.3% | +15.5% | -10.3% | |
| Q3 2024 | -17.6% | -21.3% | -38.9% | |
| Q2 2024 | +1.4% | -8.1% | -20.9% | |
| Q1 2024 | +7.6% | +4.2% | +13.6% | |
| Q4 2023 | +2.5% | -8.6% | -21.8% | |
| Q3 2023 | +6.8% | -24.8% | -11.8% | |
| Q2 2023 | +1.5% | -1.9% | -16.8% | |
| Q1 2023 | +6.9% | +6.5% | +50.9% | |
| Q4 2022 | +9.6% | +1.4% | -1.8% | |
| Q3 2022 | -18.3% | -17.0% | -28.8% | |
| Q2 2022 | +16.3% | +20.2% | +10.1% | |
| Q1 2021 | -12.4% | -22.8% | +1.5% | |
| Q1 2022 | -12.4% | -22.8% | +1.5% | |
| Q4 2019 | +6.1% | +6.1% | +1.6% | |
| Q4 2021 | +6.1% | +6.1% | +1.6% | |
| Q3 2021 | -4.1% | -3.6% | -18.8% | |
| Q4 2020 | +2.8% | +2.2% | +24.6% | |
| Q2 2021 | +2.8% | +2.2% | +24.6% | |
| Q3 2020 | — | — | — | |
| Q2 2020 | — | — | — | |
| Q1 2020 | — | — | — |
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