NASDAQ$INSM
Insmed Incorporated · Q4 2022 earnings
Q4 2022 earnings · · Investor relations
Briefing
Insmed reported financial results for the fourth quarter and full year ended December 31, 2022 and provided a business update.
Insmed reported a strong finish to 2022 with significant commercial and clinical execution. Screening is complete in adult patients in the Phase 3 ASPEN study of brensocatib in bronchiectasis, with topline results expected in the second quarter of 2024. ARIKAYCE global revenue grew 30% in 2022 compared to 2021.
- ARIKAYCE global revenue grew 30% in 2022, driven by strong U.S. performance, the ongoing launch in Japan, and contributions from European markets.
- Patient screening is complete in adult patients in the Phase 3 ASPEN study of brensocatib in bronchiectasis, with topline data expected in the second quarter of 2024.
- Insmed anticipates sharing topline efficacy and safety data from the ARISE study in the third quarter of 2023 and completing enrollment in the ENCORE study by the end of 2023.
- Insmed plans to provide an update on its early-stage research portfolio on May 8, 2023, and anticipates having at least six IND applications filed or Phase 1 studies underway by the end of 2025.
Headline financials
Revenue & EPS history
Insmed · Revenue · Quarterly
$59.3M
Revenue by segment
Insmed · $73.3M total across 2 segments · Q2 2023
- ARIKAYCE U.S.$57.7M—78.7%
- ARIKAYCE International$15.6M—21.3%
Forward guidance
Insmed expects full-year 2023 global revenues for ARIKAYCE to be between $285 million and $300 million and anticipates over 80% of total expenditures will be on its mid-to-late stage and commercial programs.
Tailwinds
- Commercialization and expansion of ARIKAYCE globally
- Advancement of brensocatib, including the Phase 3 ASPEN study
- Development across additional neutrophil-mediated diseases
- Advancement of the confirmatory, frontline clinical trial program for ARIKAYCE (ARISE and ENCORE)
- Advancement of its earlier-stage pipeline, including the Phase 2 clinical development programs for TPIP and development of its early-stage research platforms
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2022
-1.2%
Avg return
Earnings day
-0.2%
Avg return
5 days after
+1.8%
Avg return
30 days after
35%
23 / 65 earnings
Positive
+27.5%
Q2 2022
Best reaction
-23.3%
Q1 2026
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | -23.3% | -15.4% | -31.3% | |
| Q4 2025 | +6.3% | +5.0% | -10.0% | |
| Q3 2025 | +16.3% | +9.5% | +24.5% | |
| Q1 2025 | -4.0% | -3.8% | +7.8% | |
| Q4 2024 | -0.3% | -7.6% | -4.7% | |
| Q3 2024 | -2.8% | -1.4% | +6.9% | |
| Q2 2024 | +4.2% | +7.6% | +0.1% | |
| Q1 2024 | -0.1% | -2.1% | +118.7% | |
| Q4 2023 | -3.4% | +3.5% | -6.4% | |
| Q3 2023 | -6.2% | -1.5% | -5.6% | |
| Q2 2023 | +1.0% | +1.3% | +4.0% | |
| Q1 2023 | -2.0% | -4.4% | -1.3% | |
| Q4 2022 | -3.9% | -2.4% | -21.2% | |
| Q3 2022 | -1.1% | -1.2% | +4.0% | |
| Q2 2022 | +27.5% | +26.6% | +12.8% | |
| Q1 2022 | -9.9% | -19.6% | -14.5% | |
| Q4 2021 | -5.2% | -6.5% | +0.9% | |
| Q3 2021 | +14.2% | +21.3% | +9.6% | |
| Q2 2021 | +3.4% | -2.3% | +15.1% | |
| Q1 2021 | +6.7% | -11.7% | -17.0% | |
| Q4 2020 | -10.6% | -3.9% | -13.4% | |
| Q3 2020 | -6.4% | -6.8% | +13.1% | |
| Q2 2020 | +14.8% | +7.9% | +2.5% | |
| Q1 2020 | +6.5% | +13.4% | +15.4% | |
| Q4 2019 | -11.8% | -16.6% | -38.0% | |
| Q3 2019 | +10.4% | +16.6% | +36.9% | |
| Q2 2019 | -20.7% | -22.5% | -25.1% | |
| Q1 2019 | -11.7% | -11.5% | -27.8% | |
| Q4 2018 | +14.3% | +17.0% | +10.3% | |
| Q3 2018 | -4.2% | +7.2% | +15.0% | |
| Q2 2018 | +5.6% | -1.6% | -19.5% | |
| Q1 2018 | +3.9% | +2.0% | +13.9% | |
| Q4 2017 | +8.1% | -0.8% | -11.1% | |
| Q3 2017 | +10.3% | +10.8% | +13.9% | |
| Q2 2017 | -8.6% | -17.2% | -20.7% | |
| Q1 2017 | -3.2% | -7.4% | -15.6% | |
| Q4 2016 | -1.1% | +9.5% | +8.7% | |
| Q3 2016 | -6.7% | +0.8% | +4.7% | |
| Q2 2016 | -0.2% | +0.3% | +13.4% | |
| Q1 2016 | +0.4% | — | — | |
| Q4 2015 | -2.3% | — | — | |
| Q3 2015 | -20.0% | — | — | |
| Q2 2015 | -2.4% | — | — | |
| Q1 2015 | +5.6% | — | — | |
| Q4 2014 | +3.4% | — | — | |
| Q3 2014 | -0.4% | — | — | |
| Q2 2014 | -9.3% | — | — | |
| Q1 2014 | +5.2% | — | — | |
| Q4 2013 | -7.8% | — | — | |
| Q3 2013 | -1.8% | — | — | |
| Q2 2013 | -2.8% | — | — | |
| Q1 2013 | -5.0% | — | — | |
| Q4 2012 | +5.5% | — | — | |
| Q3 2012 | +4.8% | — | — | |
| Q2 2012 | -6.8% | — | — | |
| Q1 2012 | -19.5% | — | — | |
| Q4 2009 | -0.3% | — | — | |
| Q4 2011 | -0.3% | — | — | |
| Q3 2011 | -3.7% | — | — | |
| Q2 2011 | -4.7% | — | — | |
| Q4 2010 | -4.7% | — | — | |
| Q1 2011 | -6.4% | — | — | |
| Q3 2010 | +4.1% | — | — | |
| Q2 2010 | -1.9% | — | — | |
| Q1 2010 | -12.7% | — | — |
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