NASDAQ$INSM

Insmed Incorporated · Q4 2021 earnings

Q4 2021 earnings · · Investor relations

Briefing

Insmed reported financial results for Q4 2021, highlighting ARIKAYCE revenue and providing a business and pipeline update.

Insmed reported Q4 2021 total revenue of $56.1 million, compared to $41.4 million for Q4 2020. The company's cash position is expected to support ongoing programs into 2024.

  • ARIKAYCE total revenue was $56.1 million for Q4 2021 and $188.5 million for the full year 2021.
  • Insmed anticipates at least 30% year-over-year annual growth for 2022.
  • Enrollment timelines were provided for the Brensocatib Phase 3 ASPEN study and ARIKAYCE post-marketing studies (ARISE and ENCORE).
  • The company is planning to advance Brensocatib in two additional potential indications: Chronic Rhinosinusitis without Nasal Polyps (CRS) and Hidradenitis Suppurativa (HS).

Headline financials

Total Revenue

$56.1M

Previous: $41.4M+35.5%
EPS (adj)

-$0.95

Previous: -$1.00+5.0%
Capital Expenditures

$1.14M

Previous: $933K+22.4%
Free Cash Flow

-$85.3M

Previous: -$67.7M-25.9%
Net Income

-$113M

Previous: -$102M-10.5%
Operating Income

-$99.1M

Previous: -$94.5M-4.8%
Gross Profit

$42.8M

Previous: $30.6M+40.2%
Cash & Equivalents

$717M

Previous: $533M+34.5%
Total Assets

$1.24B

Previous: $796M+56.2%
Stock-Based Comp

$11.5M

Previous: $8.78M+31.2%

Revenue & EPS history

Insmed · Revenue · Quarterly

$56.1M

Q4 2021+35.5%vs Q4 2020
Beat estimate in 11 of 16 quarters(69%)
ActualEstimate

Revenue by segment

Insmed · $73.3M total across 2 segments · Q2 2023

  • ARIKAYCE U.S.
    $57.7M
  • ARIKAYCE International
    $15.6M

Forward guidance

Insmed expects full-year 2022 revenues for ARIKAYCE to increase at least 30% year over year from 2021 and anticipates that its cash on hand will support its ongoing programs into 2024.

Tailwinds

  • Commercialization and expansion of ARIKAYCE globally
  • Launch activities for ARIKAYCE in initial European countries and in Japan
  • Advancement of the frontline clinical trial program for ARIKAYCE (ARISE and ENCORE)
  • Advancement of brensocatib, including the Phase 3 ASPEN study in patients with bronchiectasis
  • Advancement of the Phase 2 clinical development programs of TPIP

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q4 2021

Historical avgQ4 2021

-1.2%

Avg return

Earnings day

-0.2%

Avg return

5 days after

+1.8%

Avg return

30 days after

35%

23 / 65 earnings

Positive

+27.5%

Q2 2022

Best reaction

-23.3%

Q1 2026

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q1 2026-23.3%-15.4%-31.3%
Q4 2025+6.3%+5.0%-10.0%
Q3 2025+16.3%+9.5%+24.5%
Q1 2025-4.0%-3.8%+7.8%
Q4 2024-0.3%-7.6%-4.7%
Q3 2024-2.8%-1.4%+6.9%
Q2 2024+4.2%+7.6%+0.1%
Q1 2024-0.1%-2.1%+118.7%
Q4 2023-3.4%+3.5%-6.4%
Q3 2023-6.2%-1.5%-5.6%
Q2 2023+1.0%+1.3%+4.0%
Q1 2023-2.0%-4.4%-1.3%
Q4 2022-3.9%-2.4%-21.2%
Q3 2022-1.1%-1.2%+4.0%
Q2 2022+27.5%+26.6%+12.8%
Q1 2022-9.9%-19.6%-14.5%
Q4 2021-5.2%-6.5%+0.9%
Q3 2021+14.2%+21.3%+9.6%
Q2 2021+3.4%-2.3%+15.1%
Q1 2021+6.7%-11.7%-17.0%
Q4 2020-10.6%-3.9%-13.4%
Q3 2020-6.4%-6.8%+13.1%
Q2 2020+14.8%+7.9%+2.5%
Q1 2020+6.5%+13.4%+15.4%
Q4 2019-11.8%-16.6%-38.0%
Q3 2019+10.4%+16.6%+36.9%
Q2 2019-20.7%-22.5%-25.1%
Q1 2019-11.7%-11.5%-27.8%
Q4 2018+14.3%+17.0%+10.3%
Q3 2018-4.2%+7.2%+15.0%
Q2 2018+5.6%-1.6%-19.5%
Q1 2018+3.9%+2.0%+13.9%
Q4 2017+8.1%-0.8%-11.1%
Q3 2017+10.3%+10.8%+13.9%
Q2 2017-8.6%-17.2%-20.7%
Q1 2017-3.2%-7.4%-15.6%
Q4 2016-1.1%+9.5%+8.7%
Q3 2016-6.7%+0.8%+4.7%
Q2 2016-0.2%+0.3%+13.4%
Q1 2016+0.4%
Q4 2015-2.3%
Q3 2015-20.0%
Q2 2015-2.4%
Q1 2015+5.6%
Q4 2014+3.4%
Q3 2014-0.4%
Q2 2014-9.3%
Q1 2014+5.2%
Q4 2013-7.8%
Q3 2013-1.8%
Q2 2013-2.8%
Q1 2013-5.0%
Q4 2012+5.5%
Q3 2012+4.8%
Q2 2012-6.8%
Q1 2012-19.5%
Q4 2009-0.3%
Q4 2011-0.3%
Q3 2011-3.7%
Q2 2011-4.7%
Q4 2010-4.7%
Q1 2011-6.4%
Q3 2010+4.1%
Q2 2010-1.9%
Q1 2010-12.7%

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