NASDAQ$DNLI
Denali Therapeutics Inc · Q2 2024 earnings
Q2 2024 earnings · · Investor relations
Briefing
Denali Therapeutics reported financial results for the second quarter ended June 30, 2024, and provided business highlights.
Denali Therapeutics reported a net loss of $99.0 million for the second quarter of 2024, compared to a net income of $183.4 million for the same period in 2023. The company had no collaboration revenue for the quarter, a decrease from $294.1 million in the previous year, primarily due to Biogen exercising their option to license the ATV:Abeta program in 2023. Cash, cash equivalents, and marketable securities were approximately $1.35 billion as of June 30, 2024.
- Enzyme Transport Vehicle franchise gained momentum with continued engagement with the FDA on an accelerated approval pathway for tividenofusp alfa (DNL310, ETV:IDS) in MPS II.
- FDA selected DNL126 (ETV:SGSH) in MPS IIIA for the START program.
- Regained the rights to TfR-based ATV:Abeta program from Biogen, expanding opportunities for addressing Alzheimer's disease.
- COMPASS, the global Phase 2/3 study, is expected to complete enrollment in 2024.
Headline financials
Revenue & EPS history
Denali Therapeutics · Revenue · Quarterly
$0
Forward guidance
This press release contains forward-looking statements regarding expectations for Denali’s TV technology platform, plans and timelines for clinical trials, potential regulatory approvals, and financial forecasts. Actual results are subject to risks and uncertainties, including adverse economic conditions, reliance on collaborations, clinical trial outcomes, and regulatory approvals.
Tailwinds
- Expectations regarding Denali’s TV technology platform
- Plans, timelines, and expectations regarding DNL310 and the ongoing Phase 2/3 COMPASS and Phase 1/2 studies
- The timing and likelihood of accelerated approval, and the timing and availability of program updates
- Plans and timelines regarding DNL343, including in Regimen G of the Phase 2/3 HEALEY ALS Platform Trial
- Plans, timelines, and expectations of both Denali and Sanofi regarding DNL788, including the Phase 2 study in MS
Headwinds
- Risks related to any and all risks to Denali’s business and operations caused by adverse economic conditions
- Risk of the occurrence of any event, change, or other circumstance that could give rise to the termination of Denali’s agreements with Sanofi, Takeda, or Biogen, or any of Denali’s other collaboration agreements
- Denali’s transition to a late-stage clinical drug development company
- Denali’s and its collaborators’ ability to complete the development and, if approved, commercialization of its product candidates
- Denali’s and its collaborators’ ability to enroll patients in its ongoing and future clinical trials
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q2 2024
-0.3%
Avg return
Earnings day
-1.4%
Avg return
5 days after
+1.3%
Avg return
30 days after
44%
14 / 32 earnings
Positive
+19.7%
Q4 2023
Best reaction
-13.7%
Q1 2022
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q4 2025 | -1.0% | -4.9% | -15.2% | |
| Q3 2025 | -3.2% | +18.1% | +34.0% | |
| Q1 2025 | +1.0% | -0.9% | +6.1% | |
| Q4 2024 | -1.5% | -15.6% | -21.8% | |
| Q3 2024 | +7.1% | +14.2% | -10.0% | |
| Q2 2024 | -10.3% | -9.7% | +0.3% | |
| Q1 2024 | +10.3% | +6.8% | +24.3% | |
| Q4 2023 | +19.7% | +23.5% | +21.5% | |
| Q3 2023 | -2.7% | -21.8% | -9.7% | |
| Q2 2023 | -5.2% | -7.6% | -7.3% | |
| Q1 2023 | +3.0% | +5.4% | +16.1% | |
| Q4 2022 | +4.8% | +7.3% | -10.9% | |
| Q3 2022 | -7.8% | -10.3% | +6.2% | |
| Q2 2022 | +4.6% | +6.6% | -17.5% | |
| Q1 2022 | -13.7% | -14.0% | -8.5% | |
| Q4 2021 | -2.8% | -7.8% | -1.9% | |
| Q3 2021 | +3.5% | -0.4% | -19.9% | |
| Q2 2021 | +3.5% | +4.6% | +6.6% | |
| Q1 2021 | -8.0% | -10.2% | +5.5% | |
| Q4 2020 | +7.5% | -5.8% | -17.2% | |
| Q3 2020 | +5.2% | +16.3% | +40.8% | |
| Q2 2020 | +6.1% | -5.4% | -2.5% | |
| Q1 2020 | -5.5% | -5.7% | +2.6% | |
| Q4 2019 | -8.6% | -10.0% | -12.5% | |
| Q3 2019 | -6.1% | -10.1% | +10.5% | |
| Q2 2019 | +0.6% | +5.4% | -4.2% | |
| Q1 2019 | -4.8% | -11.4% | -18.9% | |
| Q4 2018 | +11.7% | +12.0% | +26.4% | |
| Q3 2018 | -4.0% | -0.6% | +12.7% | |
| Q2 2018 | -0.5% | -0.7% | +17.0% | |
| Q4 2017 | -4.8% | -5.1% | +2.2% | |
| Q1 2018 | -8.8% | -8.0% | -12.4% | |
| Q3 2017 | — | — | — | |
| Q2 2017 | — | — | — | |
| Q1 2017 | — | — | — | |
| Q4 2016 | — | — | — | |
| Q3 2016 | — | — | — | |
| Q2 2016 | — | — | — | |
| Q1 2016 | — | — | — |
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