NASDAQ$ACAD
ACADIA Pharmaceuticals Inc · Q4 2021 earnings
Q4 2021 earnings · · Investor relations
Briefing
Acadia reported strong Q4 and full year results driven by growth in NUPLAZID prescriptions and market share, and resubmitted its sNDA for pimavanserin for Alzheimer’s disease psychosis to the FDA.
Acadia Pharmaceuticals reported a net sales increase of 10% year over year, driven by growth in NUPLAZID prescriptions and market share. The company resubmitted its sNDA for pimavanserin for Alzheimer’s disease psychosis to the FDA and plans to submit an NDA for trofinetide for the treatment of Rett syndrome.
- Grew NUPLAZID total prescriptions and market share, outperforming other branded drugs in neurology, the Parkinson’s market, and long-term care facilities.
- Resubmitted supplemental New Drug Application (sNDA) of NUPLAZID (pimavanserin) for the treatment of the hallucinations and delusions associated with Alzheimer’s disease psychosis (ADP) to the U.S. Food and Drug Administration (FDA).
- Delivered positive top-line results from the pivotal Phase 3 Lavender study of trofinetide in Rett syndrome and plan to submit an NDA to the FDA around mid-year 2022.
- Announced collaboration with Stoke Therapeutics to pursue multiple RNA-based treatments for severe and rare genetic neurodevelopmental diseases for SYNGAP1 syndrome, Rett syndrome (MECP2), and an undisclosed neurodevelopmental target of mutual interest.
Headline financials
Revenue & EPS history
ACADIA · Revenue · Quarterly
$131M
Revenue by segment
ACADIA · $131M total across 1 segment · Q4 2021
- NUPLAZID$131M+8.1%100.0%
Forward guidance
Acadia provided financial guidance for 2022.
Tailwinds
- NUPLAZID net sales guidance in Parkinson’s disease psychosis is $510 to $560 million.
- GAAP R&D guidance is $355 to $375 million and includes approximately $25 million of stock-based compensation expense.
- GAAP SG&A guidance is $360 to $380 million and includes approximately $45 million of stock-based compensation expense.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2021
-0.9%
Avg return
Earnings day
-0.4%
Avg return
5 days after
-1.6%
Avg return
30 days after
42%
27 / 65 earnings
Positive
+23.7%
Q3 2016
Best reaction
-22.9%
Q4 2017
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | -3.9% | -2.5% | -3.6% | |
| Q4 2025 | -1.4% | -9.9% | -16.9% | |
| Q3 2025 | -2.9% | +6.2% | +22.9% | |
| Q1 2025 | +14.4% | +16.1% | +48.4% | |
| Q4 2024 | +1.8% | -3.9% | -10.2% | |
| Q3 2024 | +14.7% | +21.8% | +15.2% | |
| Q2 2024 | -17.6% | -15.1% | -11.9% | |
| Q1 2024 | -11.8% | -12.0% | -13.7% | |
| Q4 2023 | -8.3% | -7.3% | -28.6% | |
| Q3 2023 | +5.0% | +2.5% | -1.4% | |
| Q2 2023 | -6.0% | -7.4% | -4.0% | |
| Q1 2023 | -2.3% | -2.1% | +12.3% | |
| Q4 2022 | +9.4% | +7.5% | +0.3% | |
| Q3 2022 | -6.6% | -8.6% | -0.6% | |
| Q2 2022 | -1.3% | -0.2% | +2.5% | |
| Q1 2022 | -4.9% | -17.3% | -9.6% | |
| Q4 2021 | -2.2% | -6.2% | -4.8% | |
| Q3 2021 | +7.7% | +3.1% | +8.8% | |
| Q2 2021 | -11.0% | -11.4% | -22.4% | |
| Q1 2021 | +7.3% | +7.7% | +21.4% | |
| Q4 2020 | -4.9% | -0.4% | -48.0% | |
| Q3 2020 | +4.2% | +7.4% | +16.4% | |
| Q2 2020 | +0.3% | -5.1% | -12.1% | |
| Q1 2020 | +5.3% | +2.5% | -5.3% | |
| Q4 2019 | -3.9% | +7.6% | -4.5% | |
| Q3 2019 | +0.4% | +0.4% | +7.2% | |
| Q2 2019 | +14.7% | +14.4% | +10.6% | |
| Q1 2019 | +6.0% | +11.4% | -0.2% | |
| Q4 2018 | +7.5% | +12.0% | +12.2% | |
| Q3 2018 | -7.7% | -12.9% | -12.7% | |
| Q2 2018 | -2.0% | +0.7% | -1.1% | |
| Q1 2018 | +15.6% | +15.8% | +14.3% | |
| Q4 2017 | -22.9% | -26.8% | -30.5% | |
| Q3 2017 | -9.6% | -12.1% | -7.6% | |
| Q2 2017 | +8.6% | +2.1% | +17.1% | |
| Q1 2017 | -8.6% | -8.7% | -17.8% | |
| Q4 2016 | -8.1% | -7.4% | -14.4% | |
| Q3 2016 | +23.7% | +32.8% | +24.9% | |
| Q2 2016 | -1.8% | -10.3% | -15.0% | |
| Q1 2016 | +0.4% | — | — | |
| Q4 2015 | +2.2% | — | — | |
| Q3 2015 | -13.1% | — | — | |
| Q2 2015 | -17.8% | — | — | |
| Q1 2015 | +3.2% | — | — | |
| Q4 2014 | +1.5% | — | — | |
| Q3 2014 | -0.7% | — | — | |
| Q2 2014 | +3.1% | — | — | |
| Q1 2014 | -8.4% | — | — | |
| Q4 2013 | -4.8% | — | — | |
| Q3 2013 | -7.8% | — | — | |
| Q2 2013 | -5.6% | — | — | |
| Q1 2013 | -4.4% | — | — | |
| Q4 2012 | -6.0% | — | — | |
| Q3 2012 | +11.0% | — | — | |
| Q2 2012 | -0.7% | — | — | |
| Q1 2012 | +0.0% | — | — | |
| Q4 2011 | +0.6% | — | — | |
| Q4 2009 | +0.6% | — | — | |
| Q3 2011 | -5.0% | — | — | |
| Q4 2010 | -2.9% | — | — | |
| Q2 2011 | -2.9% | — | — | |
| Q1 2011 | -4.1% | — | — | |
| Q3 2010 | +1.4% | — | — | |
| Q2 2010 | -7.5% | — | — | |
| Q1 2010 | +11.5% | — | — |
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