NASDAQ$WVE

Wave Life Sciences Ltd · Q1 2024 earnings

Q1 2024 earnings · · Investor relations

Briefing

Wave Life Sciences reported financial results for Q1 2024 and provided a business update.

Wave Life Sciences reported a net loss of $31.6 million for the first quarter of 2024, compared to a net loss of $27.4 million for the first quarter of 2023. Cash and cash equivalents were $180.9 million as of March 31, 2024. Revenue was $12.5 million for the first quarter of 2024, as compared to $12.9 million in the first quarter of 2023.

  • RestorAATion-2 clinical trial of WVE-006 in AATD patients is underway, with proof-of-mechanism data expected in 2024.
  • INHBE program for obesity is expected to initiate a clinical trial in 1Q 2025, with preclinical data showing weight loss similar to semaglutide.
  • GSK collaboration continues to advance, with the first two programs progressing after successful target validation.
  • Clinical data for the allele-selective HD program is expected in 2Q 2024, and potentially registrational data from the FORWARD-53 trial in DMD is expected in 3Q 2024.

Headline financials

Total Revenue

$12.5M

Previous: $12.9M-3.0%
EPS

-$0.24

Previous: -$0.27+11.1%
Research and Development Expense

$33.4K

Previous: $31M-99.9%
General and Administrative Expense

$13.5K

Previous: $12.2M-99.9%
Capital Expenditures

-$417K

Previous: -$489K+14.7%
Free Cash Flow

-$32M

Previous: -$27.9M-14.6%
Net Income

-$31.6M

Previous: -$27.4M-15.2%
Operating Income

-$34.5M

Previous: -$30.3M-13.8%
R&D Expense

$33.4M

No prior period

Revenue & EPS history

Wave Life Sciences · Revenue · Quarterly

$12.5M

Q1 2024-3%vs Q1 2023
Beat estimate in 6 of 15 quarters(40%)
ActualEstimate

Forward guidance

Wave Life Sciences anticipates several milestones, including clinical trial initiations and data readouts, while also managing financial runway and program advancements.

Tailwinds

  • Expected proof-of-mechanism data from RestorAATion-2 in AATD patients in 2024.
  • Planned clinical trial initiation for the INHBE obesity program in 1Q 2025.
  • Potential for weight loss similar to semaglutide with INHBE program.
  • Advancing FORWARD-53 clinical trial with potential registrational data in DMD expected in 3Q 2024.
  • WVE-003 SELECT-HD multi-dose data with extended follow-up remains on track for 2Q 2024.

Headwinds

  • Reliance on successful clinical trial outcomes and regulatory approvals.
  • Dependence on third parties for manufacturing and research.
  • Competition from other companies developing therapies for similar indications.
  • Potential delays or setbacks in clinical trial initiations or data readouts.
  • Need to manage financial resources to fund operations into 4Q 2025.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q1 2024

Historical avgQ1 2024

+1.9%

Avg return

Earnings day

+1.3%

Avg return

5 days after

+8.2%

Avg return

30 days after

48%

20 / 42 earnings

Positive

+42.4%

Q4 2023

Best reaction

-16.3%

Q1 2022

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q1 2026+8.4%+5.3%-6.9%
Q4 2025+5.6%-7.6%-56.2%
Q3 2025-10.3%-9.9%+157.4%
Q1 2025+0.5%-1.5%+11.2%
Q4 2024+11.7%-6.5%-33.9%
Q3 2024-4.6%-16.8%-15.8%
Q2 2024-9.5%-6.9%-14.2%
Q1 2024-3.9%-0.2%-0.7%
Q4 2023+42.4%+42.0%+23.4%
Q3 2023-8.9%-5.6%-21.7%
Q2 2023+14.4%+3.0%+3.9%
Q1 2023-0.8%+8.2%+23.6%
Q4 2022-11.1%-11.8%+1.9%
Q3 2022-7.6%-19.3%-1.3%
Q2 2022+37.3%+45.1%+26.7%
Q1 2022-16.3%-13.6%+46.3%
Q4 2021-5.7%-17.1%-17.5%
Q3 2021+1.5%-3.2%-25.7%
Q2 2021+7.0%-0.4%+12.3%
Q1 2021+1.5%+9.6%+18.3%
Q4 2020-7.8%-8.9%-40.5%
Q3 2020+2.8%+11.9%+19.3%
Q2 2020+1.5%-0.5%+36.9%
Q1 2020+28.2%+30.2%+28.1%
Q4 2019-3.2%+9.8%+6.6%
Q3 2019-1.0%+3.1%+20.9%
Q2 2019-3.4%-9.4%+3.1%
Q1 2019-0.8%-1.0%-10.7%
Q4 2018+6.1%+7.6%-7.3%
Q3 2018-12.3%-15.3%+4.4%
Q2 2018+10.7%+16.4%+25.7%
Q1 2018-6.9%-9.7%+11.5%
Q4 2017-7.9%-11.7%-10.5%
Q3 2017+3.2%+12.0%+66.5%
Q2 2017-7.7%-12.8%+18.4%
Q1 2017+2.6%+7.9%-2.2%
Q4 2016-2.0%-4.4%-14.8%
Q3 2016+15.3%+18.2%+5.2%
Q2 2016+5.7%+13.5%+26.9%
Q1 2016-2.7%
Q4 2015-3.1%
Q3 2015+11.1%
Q2 2015
Q1 2015
Q4 2014
Q3 2014
Q2 2014
Q1 2014

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