NASDAQ$PSNL
Personalis Inc · Q4 2025 earnings
Q4 2025 earnings · · After market close · Investor relations
Briefing
Personalis reported Q4 2025 revenue of $17.3M with a net loss of $(23.8)M, or $(0.26) per share.
Q4 2025 revenue was $17.3 million (+3% YoY) with clinical test volume of 6,183 tests (+41% sequentially). Net loss was $(23.8) million, or $(0.26) per share. Medicare coverage for breast and lung MRD surveillance positions 2026 clinical revenue to grow roughly fivefold per guidance of $78M–$80M total revenue.
- Q4 revenue $17.3M.
- Net loss $(23.8)M; EPS $(0.26).
- Clinical volume 6,183 tests (+41% vs. Q3).
- FY 2026 revenue guide $78M–$80M.
Headline financials
Revenue & EPS history
Personalis · Revenue · Quarterly
$17.3M
Revenue by segment
Personalis · $18.2M total across 4 segments · Q3 2023
- Pharma tests and services$8M—43.8%
- Enterprise sales$7.81M—42.8%
- Population sequencing$2.4M—13.2%
- Other$38K—0.2%
Forward guidance
FY 2026 revenue $78M–$80M with ~5x clinical revenue growth expected.
Tailwinds
- Medicare coverage wins for MRD assays.
- ~$240M cash supports commercial expansion.
Headwinds
- Still deeply unprofitable near term.
- Reimbursement ramp and lab capacity execution.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2025
+1.0%
Avg return
Earnings day
+1.5%
Avg return
5 days after
+1.5%
Avg return
30 days after
59%
16 / 27 earnings
Positive
+19.9%
Q1 2025
Best reaction
-23.4%
Q3 2024
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | -1.2% | -0.7% | +76.6% | |
| Q4 2025 | +0.6% | -1.1% | -29.8% | |
| Q3 2025 | -12.3% | -1.1% | +9.5% | |
| Q1 2025 | +19.9% | +27.5% | +30.3% | |
| Q4 2024 | -2.4% | +5.9% | -14.6% | |
| Q3 2024 | -23.4% | -12.8% | -26.4% | |
| Q2 2024 | +7.2% | +34.7% | +67.8% | |
| Q1 2024 | +4.4% | -2.5% | -14.6% | |
| Q4 2023 | +3.3% | +16.0% | -0.7% | |
| Q3 2023 | +10.4% | -3.8% | +39.6% | |
| Q2 2023 | +4.7% | +7.9% | -17.9% | |
| Q1 2023 | +4.5% | +3.2% | -6.4% | |
| Q4 2022 | -7.2% | -5.3% | -18.2% | |
| Q3 2022 | -1.5% | -15.3% | +4.7% | |
| Q2 2022 | +10.6% | +11.1% | -21.4% | |
| Q1 2022 | -7.2% | -24.8% | -34.1% | |
| Q4 2021 | +12.2% | +11.0% | -14.4% | |
| Q3 2021 | +2.6% | -5.4% | -38.9% | |
| Q2 2021 | +10.2% | +4.1% | +12.4% | |
| Q1 2021 | -0.6% | -9.9% | -4.3% | |
| Q4 2020 | -11.1% | -10.8% | -36.3% | |
| Q3 2020 | +0.1% | -0.3% | +13.6% | |
| Q2 2020 | -2.4% | -3.7% | -4.7% | |
| Q1 2020 | +4.6% | +7.2% | +27.6% | |
| Q4 2019 | +17.5% | +27.5% | +52.8% | |
| Q3 2019 | +0.2% | -12.7% | +0.3% | |
| Q2 2019 | -15.6% | -6.2% | -11.6% | |
| Q1 2019 | — | — | — | |
| Q4 2018 | — | — | — | |
| Q3 2018 | — | — | — | |
| Q2 2018 | — | — | — | |
| Q1 2018 | — | — | — |
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