NASDAQ$PRTA

Prothena Corporation plc · Q3 2025 earnings

Q3 2025 earnings · · After market close · Investor relations

Briefing

Prothena reported Q3 2025, revenue of $2.4M.

For Q3 2025, Prothena reported revenue of $2.4M. Management discusses operating trends, capital allocation, and outlook in the quarterly filing.

  • Revenue $2.4M.
  • Prothena highlights liquidity, costs, and near-term priorities.
  • Prothena highlights liquidity, costs, and near-term priorities.

Headline financials

Total Revenue

$2.42M

Previous: $970K+149.0%
EPS

-$0.68

Previous: -$1.10+38.2%
Capital Expenditures

-$138K

Previous: -$255K+45.9%
Free Cash Flow

-$36.7M

Previous: -$59.3M+38.1%
Net Income

-$36.5M

Previous: -$59M+38.1%
Operating Income

-$40.2M

Previous: -$66.5M+39.5%

Revenue & EPS history

Prothena · Revenue · Quarterly

$2.42M

Q3 2025+149%vs Q3 2024
Beat estimate in 3 of 14 quarters(21%)
ActualEstimate

Revenue by segment

Prothena · $84.9M total across 1 segment · Q3 2023

  • Collaboration Revenue
    $84.9M+5557.7%

Forward guidance

Clinical-stage outlook focuses on trial milestones, partnerships, and cash runway.

Tailwinds

  • Pipeline progress and collaboration revenue.
  • Balance sheet to fund R&D.
  • Regulatory optionality.

Headwinds

  • No commercial product revenue or ongoing losses.
  • Trial and FDA risk.
  • Dilution and funding needs.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q3 2025

Historical avgQ3 2025

+1.5%

Avg return

Earnings day

+0.4%

Avg return

5 days after

+0.2%

Avg return

30 days after

57%

30 / 53 earnings

Positive

+45.3%

Q4 2020

Best reaction

-12.0%

Q1 2016

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q1 2026+2.1%-8.7%-16.5%
Q4 2025-0.2%-1.7%-3.1%
Q3 2025+5.2%+7.6%+9.8%
Q1 2025+5.2%-3.0%-23.8%
Q4 2024+2.0%-4.6%-15.0%
Q3 2024-4.7%-22.5%-23.6%
Q2 2024+6.7%+3.7%+5.6%
Q1 2024-6.5%-12.0%-10.2%
Q4 2023+2.7%+0.9%-4.5%
Q3 2023+2.4%-0.7%-4.9%
Q2 2023-8.7%-9.7%-18.3%
Q1 2023+17.2%+13.0%+2.9%
Q4 2022+4.6%+7.0%-9.7%
Q3 2022-8.8%-6.6%+8.6%
Q2 2022-8.5%-2.8%-19.1%
Q1 2022-4.7%-13.7%-12.0%
Q4 2021-9.6%-8.3%+5.1%
Q3 2021-0.7%-4.8%-21.5%
Q2 2021+5.0%+5.8%+30.5%
Q1 2021-6.6%-1.8%+90.3%
Q4 2020+45.3%+46.2%+46.5%
Q3 2020+20.9%+7.3%+1.5%
Q2 2020+3.5%+1.5%+8.2%
Q1 2020-7.9%-0.8%-11.7%
Q4 2019-0.1%+0.9%-22.7%
Q3 2019-3.1%-3.0%+32.7%
Q2 2019+2.4%-2.2%-1.3%
Q1 2019+2.7%-1.9%-16.2%
Q4 2018+3.1%+4.3%+12.5%
Q3 2018+0.6%-4.1%-9.8%
Q2 2018+2.7%+8.2%+3.6%
Q1 2018-2.4%+13.1%-1.2%
Q4 2017+8.0%+11.6%+18.1%
Q3 2017-9.2%-8.6%-34.4%
Q2 2017-4.2%-7.1%-1.3%
Q1 2017+11.2%+12.2%+3.2%
Q4 2016+1.4%+5.9%+3.9%
Q3 2016-5.6%-8.3%+14.3%
Q2 2016+2.8%+2.3%-7.9%
Q1 2016-12.0%
Q4 2015+1.4%
Q3 2015+10.9%
Q2 2015-1.1%
Q1 2015-8.5%
Q4 2014-0.2%
Q3 2014-6.0%
Q2 2014+12.2%
Q1 2014+1.0%
Q4 2013+0.5%
Q3 2013+4.7%
Q2 2013-1.6%
Q1 2013+11.9%
Q4 2012+0.6%
Q3 2012
Q2 2012
Q1 2012

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