NASDAQ$IONS
Ionis Pharmaceuticals · Q4 2023 earnings
Q4 2023 earnings · · Investor relations
Briefing
Ionis Pharmaceuticals reported financial results for Q4 and full year 2023, with revenue more than doubled for the quarter and increased 34% for the full year, driven by pipeline and technology success. WAINUA was approved in the U.S., and positive Phase 3 data were reported for olezarsen and donidalorsen.
Ionis Pharmaceuticals reported strong Q4 2023 financial results, with revenue more than doubling compared to the same period in the prior year. The company achieved several milestones, including the approval of WAINUA in the U.S. and positive Phase 3 data readouts for olezarsen and donidalorsen. Ionis is preparing regulatory submissions for FCS and HAE.
- Revenue more than doubled for the fourth quarter of 2023 compared to the same period in the prior year.
- WAINUA approved in the U.S., resulting in a $50 million milestone payment from AstraZeneca.
- Positive Phase 3 olezarsen and donidalorsen data, preparing regulatory submissions for FCS and HAE, respectively
- Cash and short-term investments of $2.3 billion as of December 31, 2023.
Headline financials
Revenue & EPS history
Ionis · Revenue · Quarterly
$325M
Revenue by segment
Ionis · $151M total across 2 segments · Q2 2023
- Collaborative Agreement Rev$90M+130.8%59.6%
- SPINRAZA Royalties$61M+1.7%40.4%
Forward guidance
The Company’s 2024 guidance reflects its plan to deploy its capital resources toward growth opportunities, including continued investments in its near-term commercial opportunities, expanding its wholly owned pipeline and advancing its technology platform. Additionally, the Company expects to continue earning substantial revenue from its commercial portfolio and partnered programs.
Tailwinds
- Continued investments in near-term commercial opportunities
- Expanding its wholly owned pipeline
- Advancing its technology platform
- Continue earning substantial revenue from its commercial portfolio
- Continue earning substantial revenue from partnered programs
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2023
+0.2%
Avg return
Earnings day
+1.9%
Avg return
5 days after
+1.2%
Avg return
30 days after
51%
35 / 68 earnings
Positive
+30.2%
Q3 2016
Best reaction
-13.5%
Q3 2011
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +4.2% | +5.1% | +6.6% | |
| Q4 2025 | -5.3% | -4.1% | -15.6% | |
| Q3 2025 | -2.3% | +0.1% | +12.5% | |
| Q1 2025 | +3.0% | +12.9% | +12.4% | |
| Q4 2024 | -0.4% | -0.2% | +3.0% | |
| Q3 2024 | -0.9% | +0.2% | -1.8% | |
| Q2 2024 | -0.7% | -4.9% | -3.6% | |
| Q1 2024 | -5.0% | -7.6% | -5.7% | |
| Q4 2023 | -0.8% | +3.9% | -3.7% | |
| Q3 2023 | +4.3% | +5.4% | +14.1% | |
| Q2 2023 | +0.7% | +0.8% | +4.2% | |
| Q1 2023 | +1.3% | -1.0% | +17.5% | |
| Q4 2022 | -4.0% | -5.3% | -11.2% | |
| Q3 2022 | +7.6% | +4.2% | -11.2% | |
| Q2 2022 | +0.9% | -3.5% | -3.2% | |
| Q1 2022 | -1.2% | -17.6% | -6.1% | |
| Q4 2021 | +3.4% | +10.9% | +19.3% | |
| Q3 2021 | +5.0% | +5.8% | -20.0% | |
| Q2 2021 | +4.2% | +2.0% | +4.5% | |
| Q1 2021 | -11.1% | -13.7% | -17.7% | |
| Q4 2020 | -4.7% | -3.6% | -23.4% | |
| Q3 2020 | +3.7% | +6.6% | +9.0% | |
| Q2 2020 | -4.6% | -8.7% | -6.1% | |
| Q1 2020 | -7.7% | -2.7% | -0.3% | |
| Q4 2019 | -3.6% | -5.4% | -10.7% | |
| Q3 2019 | +1.8% | +4.2% | +18.8% | |
| Q2 2019 | +6.6% | +6.2% | -3.6% | |
| Q1 2019 | +0.9% | -2.8% | -7.2% | |
| Q4 2018 | +15.2% | +14.4% | +31.7% | |
| Q3 2018 | +5.4% | -0.0% | +8.8% | |
| Q2 2018 | +4.4% | +11.6% | +1.9% | |
| Q1 2018 | +7.4% | +3.7% | +12.9% | |
| Q4 2017 | +2.8% | -4.7% | -14.2% | |
| Q3 2017 | +0.9% | +3.0% | -0.6% | |
| Q2 2017 | -8.6% | -11.0% | +7.4% | |
| Q1 2017 | -2.6% | +3.9% | +10.3% | |
| Q4 2016 | +5.4% | +16.6% | -13.8% | |
| Q3 2016 | +30.2% | +51.0% | +44.9% | |
| Q2 2016 | +0.1% | -2.5% | -14.1% | |
| Q1 2016 | -8.7% | — | — | |
| Q4 2015 | -4.6% | — | — | |
| Q3 2015 | +14.8% | — | — | |
| Q2 2015 | +1.0% | — | — | |
| Q1 2015 | +1.2% | — | — | |
| Q4 2014 | -0.8% | — | — | |
| Q3 2014 | +4.4% | — | — | |
| Q2 2014 | +6.3% | — | — | |
| Q1 2014 | -6.5% | — | — | |
| Q4 2013 | -9.7% | — | — | |
| Q3 2013 | -6.1% | — | — | |
| Q2 2013 | -4.2% | — | — | |
| Q1 2013 | -12.4% | — | — | |
| Q4 2012 | +7.6% | — | — | |
| Q3 2012 | -7.0% | — | — | |
| Q2 2012 | +3.9% | — | — | |
| Q1 2012 | +7.6% | — | — | |
| Q4 2011 | +2.8% | — | — | |
| Q3 2011 | -13.5% | — | — | |
| Q2 2011 | -8.2% | — | — | |
| Q1 2010 | -2.7% | — | — | |
| Q1 2011 | +2.8% | — | — | |
| Q4 2008 | -1.6% | — | — | |
| Q4 2010 | -1.6% | — | — | |
| Q3 2009 | +2.5% | — | — | |
| Q3 2010 | +2.5% | — | — | |
| Q4 2009 | -3.8% | — | — | |
| Q2 2010 | -3.8% | — | — | |
| Q2 2009 | -3.8% | — | — |
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