NASDAQ$EVLO

Evelo Biosciences Inc · Q1 2021 earnings

Q1 2021 earnings · · Investor relations

Briefing

Reported financial results and business highlights for the first quarter 2021.

Evelo Biosciences reported its Q1 2021 financial results, highlighting positive data from the Phase 1b clinical trial of EDP1815 for atopic dermatitis and a strategic collaboration with Abdul Latif Jameel Health. The company also strengthened its leadership team with new appointments.

  • Presented positive data from Phase 1b clinical trial of EDP1815 for atopic dermatitis at ISAD Meeting.
  • Strengthened leadership team with the appointments of Luca Scavo as CFO and Julie H. McHugh to Board of Directors.
  • Announced strategic collaboration with Abdul Latif Jameel Health to develop and commercialize EDP1815 in select developing markets.
  • Multiple clinical data readouts expected over next 18 months.

Headline financials

Total Revenue

$0.00

Previous: $200K-100.0%
EPS (adj)

-$11.00

Previous: -$14.20+22.5%
Capital Expenditures

-$314K

Previous: -$435K+27.8%
Free Cash Flow

-$26.6M

Previous: -$20M-33.3%
Net Income

-$28.2M

Previous: -$23M-22.4%
Operating Income

-$27.5M

Previous: -$23.3M-18.1%
Gross Profit

$0.00

Previous: $200K-100.0%
Cash & Equivalents

$125M

Previous: $58.1M+114.4%
Total Assets

$153M

Previous: $83.1M+84.1%
R&D Expense

$21.5M

Previous: $17.4M+23.5%

Revenue & EPS history

Evelo · Revenue · Quarterly

$0

Q1 2021-100%vs Q1 2020

Forward guidance

Evelo Biosciences anticipates multiple clinical data readouts across its inflammatory disease portfolio in the next 18 months. Key milestones include data from the Phase 2b dose-ranging trial of EDP1815 in psoriasis anticipated in Q3 2021, and interim data from the Phase 1b trial of EDP1867 in atopic dermatitis expected in Q4 2021.

Tailwinds

  • Data from Phase 1b cohorts with tablets and capsules for Psoriasis anticipated in 3Q 2021
  • Full data from Phase 2b dose-ranging trial for Psoriasis anticipated in 3Q 2021
  • Subject to regulatory approval, initiation of Phase 2 trial in Atopic Dermatitis in 3Q 2021
  • Interim data from Phase 1b trial for Atopic Dermatitis expected in 4Q 2021
  • Initiation of clinical development for Inflammation in 2022

Headwinds

  • Given the increase in vaccination rates, and lower number of patients hospitalized with COVID-19 at clinical trial sites, COVID-19 trials will continue longer than originally planned.
  • The Company is unsure when it will be able to report data for COVID-19 trials
  • The Company will no longer be issuing guidance related to COVID-19 trials.
  • Potential delays in reporting data from clinical trials
  • Uncertainties regarding the impact of COVID-19 on clinical trial timelines

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q1 2021

Historical avgQ1 2021

+1.3%

Avg return

Earnings day

-1.4%

Avg return

5 days after

-9.7%

Avg return

30 days after

54%

13 / 24 earnings

Positive

+32.3%

Q2 2023

Best reaction

-20.3%

Q1 2022

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q4 2023+0.0%+0.0%-9.8%
Q3 2023-7.6%+4.5%+3.8%
Q2 2023+32.3%-30.5%-41.0%
Q1 2023+2.9%+10.2%-28.8%
Q4 2022-17.8%-27.0%-46.9%
Q3 2022+3.3%-3.3%-8.5%
Q2 2022-7.1%-10.5%-25.4%
Q1 2022-20.3%-14.5%-2.4%
Q4 2021+29.4%+13.5%-26.3%
Q3 2021+10.2%+27.0%+6.0%
Q2 2021-0.9%+5.0%+20.7%
Q1 2021+8.8%-14.4%+11.0%
Q4 2020+14.5%+21.2%+1.6%
Q3 2020-12.9%-5.9%+14.0%
Q2 2020-1.6%-0.5%+15.2%
Q1 2020-5.7%-14.0%-20.9%
Q4 2019+1.8%+12.2%-28.4%
Q3 2019-3.3%-6.1%-35.9%
Q2 2019+3.9%-2.2%+7.0%
Q1 2019+0.8%-1.5%-11.8%
Q4 2018+1.3%+3.0%-6.9%
Q3 2018+0.2%+3.4%+3.7%
Q2 2018-3.4%-5.9%+2.6%
Q1 2018+1.8%+2.2%-24.8%
Q4 2017
Q3 2017
Q2 2017
Q1 2017

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