NASDAQ$ENTA
Enanta Pharmaceuticals Inc · Q4 2021 earnings
Q4 2021 earnings · · Investor relations
Briefing
Reported financial results for the fiscal fourth quarter and year ended September 30, 2021.
Enanta Pharmaceuticals reported a total revenue of $23.6 million for the quarter, consisting of royalty revenue from AbbVie's hepatitis C virus (HCV) regimen MAVYRET®/MAVIRET®. Research and development expenses were $48.9 million, and general and administrative expenses totaled $8.4 million. The company recorded a net loss of $24.6 million, or a loss of $1.22 per diluted common share. Enanta's cash, cash equivalents, and marketable securities totaled $352.4 million at September 30, 2021.
- Presented first preclinical data for EDP-235, an oral protease inhibitor designed for COVID-19 treatment, with a first-in-human study planned for early 2022.
- Reported positive clinical data from two Phase 1b studies of EDP-514, a Hepatitis B Virus (HBV) core inhibitor, in viremic and NUC-Suppressed chronic HBV patients; Terminated Clinical Development of EDP-721, an Oral HBV RNA Destabilizer
- Announced decision to pursue combination approaches with Farnesoid X Receptor (FXR) Agonists for Non-Alcoholic Steatohepatitis (NASH) Through an Out-Licensing Strategy
- Royalty revenue for the quarter was $23.6 Million
Headline financials
Revenue & EPS history
Enanta Pharmaceuticals · Revenue · Quarterly
$23.6M
Revenue by segment
Enanta Pharmaceuticals · $18.9M total across 1 segment · Q3 2023
- Royalty Revenue$18.9M-3.0%100.0%
Forward guidance
Enanta provided financial guidance for fiscal year 2022, including research and development expenses between $150 million and $170 million, and general and administrative expenses between $35 million and $41 million.
Tailwinds
- Evaluating EDP-938, an N-protein inhibitor, in a broad clinical development program, consisting of three ongoing Phase 2 trials: RSVP, RSVTx and RSVPEDs.
- Enanta expects that enrollment in the RSVP study will be complete during the Northern Hemisphere winter season, if there is no further significant increase in COVID-19 or mitigation measures in those regions.
- Assuming this enrollment occurs, the company expects data in the first half of 2022.
- Enanta plans to move EDP-235 into the clinic in early 2022.
- On schedule to select a clinical candidate with potent nanomolar activity against both RSV-A and RSV-B by year-end.
Headwinds
- For RSVTx and RSVPEDs, which were initiated more recently, enrollment is expected to require more than one global RSV season, subject to the uncertainties of the continuing pandemic.
- Terminated development of EDP-721, an oral HBV RNA destabilizer due to adverse safety signals in a Phase 1 healthy volunteer study.
- Announced a strategic decision to discontinue internal development of FXR agonists EDP-305 and EDP-297, to prioritize combination approaches for NASH through out-licensing.
- The dependence of Enanta’s revenues in the short-term upon the continued success of AbbVie’s sales of its MAVYRET/MAVIRET HCV regimen
- Enanta’s lack of clinical development experience
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports · overlaid with Q4 2021
-1.3%
Avg return
Earnings day
-1.2%
Avg return
5 days after
-1.0%
Avg return
30 days after
41%
24 / 58 earnings
Positive
+14.8%
Q4 2021
Best reaction
-29.2%
Q2 2023
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q2 2026 | -6.1% | -13.4% | -26.0% | |
| Q1 2026 | +2.2% | +0.1% | -3.0% | |
| Q4 2025 | -3.5% | -0.7% | +13.3% | |
| Q2 2025 | -5.6% | +3.6% | +33.5% | |
| Q1 2025 | +14.1% | +45.7% | +39.4% | |
| Q4 2024 | -8.4% | -7.9% | -34.7% | |
| Q3 2024 | -6.5% | -9.5% | -12.7% | |
| Q2 2024 | -13.6% | -16.6% | -18.3% | |
| Q1 2024 | -1.4% | -1.7% | +22.8% | |
| Q4 2023 | +9.2% | +8.9% | -6.7% | |
| Q3 2023 | -6.6% | -19.8% | -38.8% | |
| Q2 2023 | -29.2% | -29.7% | -27.0% | |
| Q1 2023 | -0.5% | +0.2% | -12.1% | |
| Q4 2022 | -2.9% | -11.2% | +0.3% | |
| Q3 2022 | -3.8% | -4.2% | -10.4% | |
| Q2 2022 | -1.9% | -13.2% | -24.4% | |
| Q1 2022 | +2.8% | +1.8% | +3.9% | |
| Q4 2021 | +14.8% | +22.0% | +2.7% | |
| Q3 2021 | +5.6% | +6.3% | +35.8% | |
| Q2 2021 | -6.9% | -5.6% | -8.5% | |
| Q1 2021 | +3.1% | -3.3% | -3.9% | |
| Q4 2020 | -1.6% | -1.5% | -2.9% | |
| Q3 2020 | -2.1% | +0.2% | +4.4% | |
| Q2 2020 | -0.6% | +1.8% | -0.5% | |
| Q1 2020 | -0.1% | -5.4% | -2.3% | |
| Q4 2019 | -1.8% | +1.1% | +3.4% | |
| Q3 2019 | +6.0% | +7.4% | +0.7% | |
| Q2 2019 | -0.0% | -3.2% | +0.5% | |
| Q1 2019 | +11.6% | +11.2% | +22.9% | |
| Q4 2018 | +1.5% | +0.2% | -11.1% | |
| Q3 2018 | -6.4% | -6.3% | -11.4% | |
| Q2 2018 | -4.5% | -3.6% | +7.7% | |
| Q1 2018 | -19.0% | -16.7% | -7.5% | |
| Q4 2017 | -5.9% | -1.4% | +18.0% | |
| Q3 2017 | +2.2% | +2.0% | +11.6% | |
| Q2 2017 | +9.3% | +8.0% | -3.3% | |
| Q1 2017 | -6.5% | -7.5% | -8.9% | |
| Q4 2016 | +7.4% | +9.0% | +10.0% | |
| Q3 2016 | +2.3% | +6.4% | +4.3% | |
| Q2 2016 | -1.8% | — | — | |
| Q1 2016 | +1.8% | — | — | |
| Q4 2015 | -2.0% | — | — | |
| Q3 2015 | -13.8% | — | — | |
| Q2 2015 | -0.1% | — | — | |
| Q1 2015 | -4.2% | — | — | |
| Q4 2014 | +4.3% | — | — | |
| Q3 2014 | +4.6% | — | — | |
| Q2 2014 | +5.2% | — | — | |
| Q1 2014 | -3.6% | — | — | |
| Q1 2013 | -3.6% | — | — | |
| Q4 2011 | -22.6% | — | — | |
| Q1 2012 | -22.6% | — | — | |
| Q4 2013 | +8.5% | — | — | |
| Q3 2013 | +7.4% | — | — | |
| Q3 2012 | +7.4% | — | — | |
| Q2 2012 | +5.5% | — | — | |
| Q4 2012 | +5.5% | — | — | |
| Q2 2013 | +0.7% | — | — |
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