NASDAQ$BCYC

Bicycle Therapeutics plc · Q3 2022 earnings

Q3 2022 earnings · · Investor relations

Briefing

Reported third quarter financial results and provided a corporate update.

Bicycle Therapeutics reported continued clinical progress across its pipeline and a strong balance sheet, supported by a $10 million option fee from Genentech. The company expects its financial runway to extend into 2025.

  • Continued clinical progress across pipeline including BT5528 end of Phase I dose escalation update.
  • Completion of enrollment in BT5528 initial dose expansion cohorts expected in Q4.
  • BT8009 clinical update remains on-track for Q4.
  • Received $10 million option fee payment from Genentech this quarter.

Headline financials

Total Revenue

$3.04M

Previous: $4.33M-29.8%
EPS (adj)

-$0.96

Previous: -$0.59-62.7%
Capital Expenditures

-$17.5M

Previous: -$963K-1721.3%
Free Cash Flow

-$45.9M

Previous: -$15.6M-193.4%
Net Income

-$28.3M

Previous: -$14.7M-93.1%
Operating Income

-$29.8M

Previous: -$14.3M-108.2%
Gross Profit

-$18.4M

Previous: -$5.79M-217.3%
Cash & Equivalents

$361M

Previous: $260M+39.3%
Total Assets

$417M

Previous: $281M+48.3%
Stock-Based Comp

$5.37M

Previous: $2.69M+99.7%

Revenue & EPS history

Bicycle · Revenue · Quarterly

$3.04M

Q3 2022-29.8%vs Q3 2021
Beat estimate in 6 of 14 quarters(43%)
ActualEstimate

Forward guidance

Bicycle Therapeutics anticipates continued advancement of its product candidates, dosing in and progression of its clinical trials, and expansion of its discovery efforts and early development pipeline, with an expected financial runway into 2025.

Tailwinds

  • Advancement of product candidates BT5528, BT8009 and BT7480
  • Dosing in and progression of clinical trials
  • Availability and timing of announcement of data from clinical trials
  • Therapeutic potential for Bicycles in oncology and other applications
  • Plans to expand discovery efforts and early development pipeline

Headwinds

  • Risks to clinical trial site initiation, patient enrollment and follow-up due to the ongoing COVID-19 pandemic
  • Uncertainties inherent in the initiation and completion of clinical trials and clinical development of product candidates
  • Risk that Bicycle may not realize the intended benefits of its technology
  • Risk that projections regarding expected financial runway are inaccurate or that conduct of business requires more cash than anticipated
  • Potential adverse effects arising from the testing or use of product candidates

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q3 2022

Historical avgQ3 2022

+1.2%

Avg return

Earnings day

-1.6%

Avg return

5 days after

+0.1%

Avg return

30 days after

52%

14 / 27 earnings

Positive

+19.3%

Q4 2019

Best reaction

-10.8%

Q1 2022

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q1 2026-0.2%+3.6%-0.8%
Q4 2025-4.2%-13.9%+1.8%
Q3 2025+6.7%-16.0%-8.6%
Q1 2025+6.1%-13.6%-4.0%
Q4 2024-1.3%-2.5%-18.3%
Q3 2024-5.5%-2.2%-15.1%
Q2 2024-0.7%+2.1%-10.0%
Q1 2024+1.6%-4.6%-8.3%
Q4 2023+3.1%+9.5%+14.9%
Q3 2023+1.2%-0.7%-2.3%
Q2 2023+1.3%-2.8%-4.1%
Q1 2023-0.4%+2.5%+15.7%
Q4 2022-1.9%-5.5%-6.2%
Q3 2022-3.2%+0.8%+29.6%
Q2 2022+14.8%+17.7%+12.8%
Q1 2022-10.8%-22.6%-33.6%
Q4 2021-1.2%-9.7%-7.6%
Q3 2021+0.7%+2.5%-6.8%
Q2 2021+1.8%+2.3%+36.0%
Q1 2021+1.9%-1.3%-5.5%
Q4 2020+1.9%+2.0%+3.8%
Q3 2020-1.5%+3.1%+5.2%
Q2 2020-0.2%+0.0%+5.8%
Q1 2020+0.7%+6.6%+23.2%
Q4 2019+19.3%+1.5%-2.3%
Q3 2019-4.2%-7.7%-4.8%
Q2 2019+5.9%+5.4%-6.6%
Q1 2019
Q4 2018
Q3 2018
Q2 2018
Q1 2018
Q4 2017

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