NASDAQ$ALLO
Allogene Therapeutics Inc. · Q1 2025 earnings
Q1 2025 earnings · · After market close · Investor relations
Briefing
Allogene Therapeutics reported its first quarter 2025 financial results and business update.
Allogene Therapeutics reported a net loss of $59.7 million for the first quarter of 2025, with an EPS of -$0.28. The company ended the quarter with $335.5 million in cash, cash equivalents, and investments, and has extended its cash runway into the second half of 2027 through strategic cost realignment.
- Nearly 50 sites activated across U.S. for the Pivotal Phase 2 ALPHA3 Trial with Cemacabtagene Ansegedleucel (Cema-Cel) in First-Line (1L) Consolidation in Large B-Cell Lymphoma (LBCL).
- The Phase 1 RESOLUTION Trial with ALLO-329 in Autoimmune Disease (AID) is on track for a mid-2025 start in rheumatology, with proof-of-concept data moved to 1H 2026.
- Updated Phase 1 TRAVERSE Trial results for ALLO-316 in Renal Cell Carcinoma (RCC) will be featured in an oral presentation at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting.
- Strategic cost realignment and prioritization efforts have extended the cash runway into the second half of 2027.
Headline financials
Revenue & EPS history
Allogene · Revenue · Quarterly
$0
Forward guidance
Allogene Therapeutics expects to extend its cash runway into the second half of 2027 due to strategic cost realignment. The company anticipates a decrease in cash, cash equivalents, and investments by approximately $150 million for 2025, with GAAP Operating Expenses expected to be around $230 million.
Tailwinds
- Cash runway extended into the second half of 2027.
- Spend focused on advancing Cema-Cel/ALPHA3 and ALLO-329/RESOLUTION clinical trials to key inflection points.
- Targeted reductions in manufacturing operations provide key savings while preserving core capabilities.
- Strategic cost-realignment efforts prioritize high-impact, value-generating programs.
- Unmatched efficiencies of allogeneic platform reinforce confidence in approach.
Headwinds
- Lymphodepletion selection and futility analysis shifted to 1H 2026 due to site-related factors.
- Proof-of-Concept Data for ALLO-329 moved to 1H 2026.
- Expected decrease in cash, cash equivalents, and investments of approximately $150 million for 2025.
- GAAP Operating Expenses expected to be approximately $230 million, including estimated non-cash stock-based compensation expense of approximately $45 million.
- Estimates exclude any impact from potential business development activities.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports · overlaid with Q1 2025
+1.1%
Avg return
Earnings day
-2.7%
Avg return
5 days after
-5.0%
Avg return
30 days after
53%
16 / 30 earnings
Positive
+23.7%
Q3 2023
Best reaction
-11.8%
Q3 2020
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +0.4% | -16.0% | -17.7% | |
| Q4 2025 | -2.8% | -13.0% | +10.1% | |
| Q3 2025 | +10.7% | +17.1% | +36.2% | |
| Q1 2025 | -1.8% | -1.8% | +23.4% | |
| Q4 2024 | +2.6% | -10.6% | -23.3% | |
| Q3 2024 | -4.3% | -11.8% | -32.0% | |
| Q2 2024 | -7.5% | -7.5% | -5.5% | |
| Q1 2024 | +7.2% | +0.4% | -6.9% | |
| Q4 2023 | -4.5% | -10.0% | -22.1% | |
| Q3 2023 | +23.7% | +15.9% | -11.0% | |
| Q2 2023 | +7.3% | -11.3% | -15.4% | |
| Q1 2023 | +20.6% | +18.1% | +4.9% | |
| Q4 2022 | +0.2% | -5.4% | -21.5% | |
| Q3 2022 | -9.9% | -14.2% | -10.5% | |
| Q2 2022 | +1.5% | +8.1% | -3.5% | |
| Q1 2022 | +2.3% | -18.9% | -8.0% | |
| Q4 2021 | -4.8% | -5.9% | -0.7% | |
| Q3 2021 | -0.1% | -5.8% | -12.6% | |
| Q2 2021 | +8.2% | +3.2% | +16.1% | |
| Q1 2021 | -0.7% | -1.4% | -19.0% | |
| Q4 2020 | +0.8% | +0.5% | -1.9% | |
| Q3 2020 | -11.8% | -17.5% | -0.4% | |
| Q2 2020 | +0.3% | -0.6% | -10.9% | |
| Q1 2020 | -0.9% | +8.2% | +38.1% | |
| Q4 2019 | +6.1% | +8.1% | -21.7% | |
| Q3 2019 | -10.5% | -5.5% | +2.1% | |
| Q2 2019 | +4.4% | -0.9% | -7.4% | |
| Q1 2019 | -2.1% | -2.5% | -16.5% | |
| Q4 2018 | -4.7% | -9.3% | -5.7% | |
| Q3 2018 | +3.8% | +8.3% | -5.5% | |
| Q2 2018 | — | — | — | |
| Q1 2018 | — | — | — |
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