NASDAQ$ALLO
Allogene Therapeutics Inc. · Q4 2023 earnings
Q4 2023 earnings · · Investor relations
Briefing
Allogene reported financial results and provided a corporate update for Q4 2023.
Allogene Therapeutics ended 2023 with $448.7 million in cash, cash equivalents and investments and anticipates its cash runway will fund operations into 2026. Start-up activities for the ALPHA3 trial are underway and the trial is expected to begin in mid-2024. Initial data readout from Phase 1 ALPHA2 CLL cohort (n=12) is projected by year-end 2024. ALLO-329 is expected to enter Phase 1 clinical trials in early 2025.
- Cema-cel Pivotal ALPHA3 First Line (1L) Consolidation Trial in Large B-Cell Lymphoma (LBCL): Start-Up Activities Underway; Enrollment to Begin Mid-2024
- Cema-cel Phase 1 ALPHA2 Trial in Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL): Enrolling Patients with Initial Data Projected YE 2024
- ALLO-329 in Autoimmune Disease (AID): Differentiated Next-Generation CD19 Dagger® Program Designed for AID will Focus on Eliminating Lymphodepletion and Meeting Demand; Phase 1 Clinical Trials in Early 2025
- Ended 2023 with $448.7 Million in Cash, Cash Equivalents and Investments; Reiterates Cash Runway Projection into 2026
Headline financials
Revenue & EPS history
Allogene · Revenue · Quarterly
$21K
Forward guidance
The Company expects a decrease in cash, cash equivalents, and investments of approximately $190 million in 2024. Based on current assumptions, the Company continues to expect its cash runway to fund operations into 2026. GAAP Operating Expenses are expected to be approximately $280 million, including estimated non-cash stock-based compensation expense of approximately $60 million. These estimates exclude any impact from potential business development activities.
Tailwinds
- Cash runway to fund operations into 2026.
- GAAP Operating Expenses are expected to be approximately $280 million.
- Estimated non-cash stock-based compensation expense of approximately $60 million.
- Start-up activities for the ALPHA3 trial are underway and the trial is expected to begin in mid-2024.
- ALLO-329 is expected to enter Phase 1 clinical trials in early 2025.
Headwinds
- The Company expects a decrease in cash, cash equivalents, and investments of approximately $190 million in 2024.
- Estimates exclude any impact from potential business development activities.
- Net loss for the fourth quarter of 2023 was $85.8 million
- ALPHA3 trial will initially test two lymphodepletion regimens (one with standard fludarabine and cyclophosphamide plus ALLO-647 and one without ALLO-647).
- One lymphodepletion arm will be discontinued following a planned interim analysis in mid-2025 designed to select the most appropriate regimen for this patient population.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports · overlaid with Q4 2023
+1.1%
Avg return
Earnings day
-2.7%
Avg return
5 days after
-5.0%
Avg return
30 days after
53%
16 / 30 earnings
Positive
+23.7%
Q3 2023
Best reaction
-11.8%
Q3 2020
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +0.4% | -16.0% | -17.7% | |
| Q4 2025 | -2.8% | -13.0% | +10.1% | |
| Q3 2025 | +10.7% | +17.1% | +36.2% | |
| Q1 2025 | -1.8% | -1.8% | +23.4% | |
| Q4 2024 | +2.6% | -10.6% | -23.3% | |
| Q3 2024 | -4.3% | -11.8% | -32.0% | |
| Q2 2024 | -7.5% | -7.5% | -5.5% | |
| Q1 2024 | +7.2% | +0.4% | -6.9% | |
| Q4 2023 | -4.5% | -10.0% | -22.1% | |
| Q3 2023 | +23.7% | +15.9% | -11.0% | |
| Q2 2023 | +7.3% | -11.3% | -15.4% | |
| Q1 2023 | +20.6% | +18.1% | +4.9% | |
| Q4 2022 | +0.2% | -5.4% | -21.5% | |
| Q3 2022 | -9.9% | -14.2% | -10.5% | |
| Q2 2022 | +1.5% | +8.1% | -3.5% | |
| Q1 2022 | +2.3% | -18.9% | -8.0% | |
| Q4 2021 | -4.8% | -5.9% | -0.7% | |
| Q3 2021 | -0.1% | -5.8% | -12.6% | |
| Q2 2021 | +8.2% | +3.2% | +16.1% | |
| Q1 2021 | -0.7% | -1.4% | -19.0% | |
| Q4 2020 | +0.8% | +0.5% | -1.9% | |
| Q3 2020 | -11.8% | -17.5% | -0.4% | |
| Q2 2020 | +0.3% | -0.6% | -10.9% | |
| Q1 2020 | -0.9% | +8.2% | +38.1% | |
| Q4 2019 | +6.1% | +8.1% | -21.7% | |
| Q3 2019 | -10.5% | -5.5% | +2.1% | |
| Q2 2019 | +4.4% | -0.9% | -7.4% | |
| Q1 2019 | -2.1% | -2.5% | -16.5% | |
| Q4 2018 | -4.7% | -9.3% | -5.7% | |
| Q3 2018 | +3.8% | +8.3% | -5.5% | |
| Q2 2018 | — | — | — | |
| Q1 2018 | — | — | — |
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