NYSE$PLX
Protalix Biotherapeutics Inc · Q1 2025 earnings
Q1 2025 earnings · · Before market open · Investor relations
Briefing
Protalix BioTherapeutics reported its first quarter 2025 financial and business results, showing increased revenues and progress in clinical trials.
Protalix BioTherapeutics reported a solid first quarter in 2025 with a significant increase in revenues from selling goods. The company is focused on advancing its gout candidate, PRX-115, into a phase II clinical trial later this year, following promising phase I results.
- Total revenue for Q1 2025 was $10.113 million, an increase from $3.748 million in Q1 2024.
- Net loss for Q1 2025 was $3.619 million, or $0.05 per share, an improvement from a net loss of $4.595 million, or $0.06 per share, in Q1 2024.
- The company successfully completed the First-in-Human (FIH) phase I clinical trial of PRX-115, its gout candidate, in 2024.
- Protalix plans to initiate a phase II clinical trial for PRX-115 in patients with gout during the second half of 2025.
Headline financials
Revenue & EPS history
Protalix · Revenue · Quarterly
$10.1M
Revenue by segment
Protalix · $3.18M total across 1 segment · Q2 2021
- License & R&D$3.18M—100.0%
Forward guidance
Protalix BioTherapeutics is focused on advancing its lead gout candidate, PRX-115, into a Phase II clinical trial in the second half of 2025, building on promising Phase I results. The company also continues to evaluate other pipeline candidates for future development.
Tailwinds
- Successful completion of the First-in-Human (FIH) phase I clinical trial of PRX-115.
- Preliminary results of PRX-115 FIH study demonstrate potential for effective uric acid-lowering treatment with wide dosing interval.
- Plans to initiate a phase II clinical trial for PRX-115 in patients with gout during the second half of 2025.
- Continued evaluation of additional pipeline candidates, including PRX-119 and early-stage clinical assets.
- PRX-115 results were presented at the American College of Rheumatology (ACR) Convergence 2024, indicating positive scientific recognition.
Headwinds
- Further studies are needed to confirm the long-term safety and efficacy of PRX-115.
- Expectation of minimal revenues from license and R&D services other than potential regulatory milestone payments.
- Drug discovery and development involve a high degree of risk, and final clinical trial results may differ from preliminary findings.
- Risks related to the commercialization of Elfabrio®, including market acceptance, competition, reimbursement, and regulatory actions.
- Potential disruptions to operations due to geopolitical conflicts and instability in the banking industry.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports · overlaid with Q1 2025
-1.3%
Avg return
Earnings day
-1.7%
Avg return
5 days after
-6.0%
Avg return
30 days after
44%
28 / 64 earnings
Positive
+15.7%
Q2 2023
Best reaction
-36.4%
Q2 2019
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +2.1% | +0.0% | — | |
| Q4 2025 | +1.8% | -23.7% | -16.8% | |
| Q3 2025 | -10.9% | -12.1% | -16.4% | |
| Q1 2025 | +0.0% | +2.4% | -10.8% | |
| Q4 2024 | +9.4% | +11.2% | +16.1% | |
| Q3 2024 | +12.9% | +31.5% | +45.2% | |
| Q2 2024 | -8.7% | -7.7% | +1.0% | |
| Q1 2024 | -8.8% | -9.6% | -10.4% | |
| Q4 2023 | -12.5% | -14.5% | -22.4% | |
| Q3 2023 | -18.9% | -27.6% | -14.1% | |
| Q2 2023 | +15.7% | +15.7% | +13.9% | |
| Q1 2023 | +3.8% | -7.3% | -29.8% | |
| Q4 2022 | +6.6% | +12.6% | +11.0% | |
| Q3 2022 | +0.9% | +1.9% | +10.5% | |
| Q2 2022 | -0.4% | -2.4% | -11.4% | |
| Q1 2022 | +0.9% | +7.5% | +1.9% | |
| Q4 2021 | +0.0% | +40.0% | +10.5% | |
| Q3 2021 | -3.5% | -14.0% | -21.9% | |
| Q2 2021 | +2.2% | +0.0% | -0.7% | |
| Q1 2021 | +0.7% | -1.0% | -24.4% | |
| Q4 2020 | -5.1% | -4.5% | -24.7% | |
| Q3 2020 | -7.9% | -9.3% | +2.0% | |
| Q2 2020 | +2.2% | +3.3% | -6.1% | |
| Q1 2020 | +2.7% | +7.5% | +12.3% | |
| Q4 2019 | -3.0% | -5.1% | +3.8% | |
| Q3 2019 | -5.2% | -8.7% | +34.8% | |
| Q2 2019 | -36.4% | -29.7% | -40.5% | |
| Q1 2019 | -2.7% | -6.8% | -15.9% | |
| Q4 2018 | +1.8% | -6.1% | -12.2% | |
| Q3 2018 | -5.2% | -14.3% | -12.2% | |
| Q2 2018 | -2.0% | +0.0% | -6.0% | |
| Q1 2018 | +2.2% | +12.5% | +15.0% | |
| Q4 2017 | -1.4% | +1.5% | -33.8% | |
| Q3 2017 | -6.6% | -1.4% | -15.1% | |
| Q2 2017 | -4.6% | -12.3% | -4.6% | |
| Q1 2017 | -6.0% | -13.0% | -5.4% | |
| Q4 2016 | -4.7% | -14.1% | -18.0% | |
| Q3 2016 | +12.1% | +34.1% | -26.8% | |
| Q2 2016 | -1.5% | -1.6% | -4.7% | |
| Q1 2016 | -0.6% | — | — | |
| Q4 2015 | +4.7% | — | — | |
| Q3 2015 | -3.8% | — | — | |
| Q2 2015 | +3.8% | — | — | |
| Q1 2015 | +1.4% | — | — | |
| Q4 2014 | -5.4% | — | — | |
| Q3 2014 | -1.5% | — | — | |
| Q2 2014 | -1.3% | — | — | |
| Q1 2014 | -0.5% | — | — | |
| Q4 2013 | -2.5% | — | — | |
| Q3 2013 | +0.2% | — | — | |
| Q2 2013 | +4.3% | — | — | |
| Q1 2013 | -1.1% | — | — | |
| Q4 2012 | +4.0% | — | — | |
| Q3 2012 | +1.3% | — | — | |
| Q2 2012 | +1.4% | — | — | |
| Q1 2012 | +2.8% | — | — | |
| Q4 2011 | -1.5% | — | — | |
| Q3 2011 | +1.3% | — | — | |
| Q2 2011 | -9.7% | — | — | |
| Q1 2011 | -0.8% | — | — | |
| Q4 2010 | -1.3% | — | — | |
| Q3 2010 | -4.4% | — | — | |
| Q2 2010 | +0.1% | — | — | |
| Q1 2010 | +6.2% | — | — |
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