NASDAQ$RVMD

REVOLUTION Medicines Inc · Q4 2025 earnings

Q4 2025 earnings · · After market close · Investor relations

Briefing

Revolution Medicines reported Q4 2025, a net loss of $364.9M, diluted EPS of $-1.86.

For Q4 2025, Revolution Medicines reported a net loss of $364.9M, diluted EPS was $-1.86. Management discusses segment performance, capital allocation, and macro risks in the quarterly filing.

  • Net loss $364.9M.
  • Diluted EPS $-1.86.
  • Revolution Medicines MD&A covers liquidity, operations, and outlook.

Headline financials

Total Revenue

$0.00

Previous: $0.00
EPS (adj)

-$1.86

Previous: -$1.12-66.1%
R&D Expenses

$295M

Previous: $188M+56.8%
G&A Expenses

$66.7M

Previous: $28.2M+136.3%
Cash & Marketable Sec.

$2.03B

Previous: $2.29B-11.5%
Total Liabilities

$723M

Previous: $293M+146.7%
Net Income

-$365M

Previous: -$195M-87.5%
Operating Income

-$362M

Previous: -$216M-67.2%

Revenue & EPS history

Revolution Medicines · Revenue · Quarterly

$0

Q4 2025
Beat estimate in 3 of 14 quarters(21%)
ActualEstimate

Forward guidance

The quarterly filing discusses operating priorities, capital returns, and sector risks; numeric multi-quarter bridges vary by issuer.

Tailwinds

  • MD&A highlights liquidity, capital, and core business trends.
  • Segment or product commentary supports the earnings narrative.

Headwinds

  • Macro, rates, or input costs may pressure near-term margins.
  • One-time items can affect year-over-year comparability.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q4 2025

Historical avgQ4 2025

+0.1%

Avg return

Earnings day

+0.2%

Avg return

5 days after

+6.7%

Avg return

30 days after

42%

11 / 26 earnings

Positive

+11.7%

Q3 2020

Best reaction

-11.7%

Q2 2021

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q1 2026+2.6%-2.1%+1.4%
Q4 2025-0.9%-2.7%-10.4%
Q3 2025+3.5%+8.0%+34.2%
Q2 2025-4.7%-3.8%+10.4%
Q1 2025+11.4%+6.1%+9.1%
Q4 2024-3.5%-6.3%-7.8%
Q3 2024+4.1%+6.8%-15.3%
Q2 2024-3.0%-0.7%-3.3%
Q1 2024-3.7%-4.4%+3.8%
Q4 2023+3.0%+0.2%+6.7%
Q3 2023-3.0%-11.1%+8.2%
Q2 2023-0.1%+1.2%+8.3%
Q1 2023+3.5%+6.3%+10.6%
Q4 2022+10.0%+4.6%-11.5%
Q3 2022-4.1%+8.1%+17.8%
Q2 2022+0.5%+4.2%-11.1%
Q1 2022-6.4%-7.8%+15.4%
Q4 2021-6.4%-12.7%+29.1%
Q3 2021-1.7%-2.5%-24.4%
Q2 2021-11.7%-5.6%+9.7%
Q1 2021+7.1%+8.2%+10.7%
Q4 2020-9.2%-1.1%+1.8%
Q3 2020+11.7%+10.7%+17.4%
Q2 2020+6.9%-3.8%+8.3%
Q1 2020-1.3%+0.8%+4.9%
Q4 2019-2.5%+4.2%+49.6%
Q3 2019
Q2 2019
Q1 2019
Q4 2018

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