NASDAQ$PRLD
Prelude Therapeutics Inc · Q3 2024 earnings
Q3 2024 earnings · · Investor relations
Briefing
Reported third quarter financial results and provided a corporate update.
Prelude Therapeutics reported its third quarter financial results, highlighting the clinical proof of concept for PRT3789, its IV SMARCA2 degrader, and the initiation of a Phase 1 trial for PRT7732, its oral SMARCA2 degrader. The company's cash runway extends into 2026, with $153.6 million in cash, cash equivalents, and marketable securities as of September 30, 2024.
- Demonstrated clinical proof of concept with PRT3789, its IV SMARCA2 degrader.
- Initiated a Phase 1 trial for PRT7732, its oral SMARCA2 degrader.
- Presented first preclinical data from its next generation degrader antibody conjugate (Precision ADC) platform
- Interim phase 1 clinical data with potentially best-in-class CDK9 inhibitor, PRT2527, in hematological malignancies to be presented at the American Society of Hematology Annual Meeting in December 2024
Headline financials
Revenue & EPS history
Prelude Therapeutics · Revenue · Quarterly
$3M
Forward guidance
Prelude Therapeutics anticipates continued progress in its clinical development programs, including completing monotherapy dose escalation for PRT3789, advancing PRT7732, and presenting interim clinical data for PRT2527.
Tailwinds
- Completing monotherapy dose escalation for PRT3789 by year-end 2024.
- Advancing PRT3789 into the next phase of development, initially in NSCLC and esophageal cancers.
- Continuing enrollment in the PRT3789 combination study with docetaxel.
- Reporting progress on PRT7732 beginning early 2025.
- Presenting interim clinical data for PRT2527 at the American Society of Hematology Annual Meeting in December 2024.
Headwinds
- Clinical trial outcomes are inherently uncertain.
- Potential delays in enrollment of eligible patients.
- Risks related to supply chain and manufacturing facilities.
- Uncertainties in achieving development goals.
- Dependence on ability to fund development activities.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports · overlaid with Q3 2024
+5.5%
Avg return
Earnings day
+6.7%
Avg return
5 days after
+5.1%
Avg return
30 days after
50%
11 / 22 earnings
Positive
+37.0%
Q4 2023
Best reaction
-8.2%
Q3 2022
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | -3.1% | -6.7% | -14.2% | |
| Q4 2025 | +5.8% | -6.7% | +13.3% | |
| Q3 2025 | +10.7% | +22.2% | +26.7% | |
| Q1 2025 | -4.1% | -2.5% | +2.5% | |
| Q4 2024 | +4.1% | +1.7% | +14.4% | |
| Q3 2024 | -1.6% | -7.8% | -26.0% | |
| Q2 2024 | +21.6% | +2.2% | -2.0% | |
| Q1 2024 | -6.3% | -2.6% | -1.3% | |
| Q4 2023 | +37.0% | +23.1% | +40.2% | |
| Q3 2023 | +30.8% | +74.6% | +90.8% | |
| Q2 2023 | -2.1% | -4.8% | -2.4% | |
| Q1 2023 | -3.8% | +3.4% | -12.3% | |
| Q4 2022 | +9.2% | +12.0% | +35.1% | |
| Q3 2022 | -8.2% | -12.5% | -38.8% | |
| Q2 2022 | +21.7% | +32.4% | +21.2% | |
| Q1 2022 | +1.0% | +15.5% | +22.0% | |
| Q4 2021 | +16.9% | +3.1% | -16.4% | |
| Q3 2021 | -5.4% | -6.5% | -17.7% | |
| Q2 2021 | -5.3% | -5.7% | -3.4% | |
| Q1 2021 | +8.8% | +3.3% | -21.3% | |
| Q4 2020 | -2.6% | -5.4% | -41.3% | |
| Q3 2020 | -3.4% | +15.3% | +43.4% | |
| Q2 2020 | — | — | — | |
| Q1 2020 | — | — | — | |
| Q4 2019 | — | — | — | |
| Q3 2019 | — | — | — | |
| Q2 2019 | — | — | — | |
| Q1 2019 | — | — | — |
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