NASDAQ$MIRM
Mirum Pharmaceuticals Inc · Q4 2025 earnings
Q4 2025 earnings · · After market close · Investor relations
Briefing
Mirum Pharmaceuticals reported Q4 2025 net product revenue of $148.9 million and full-year revenue of $521.3 million, with 2026 sales guidance of $630–650 million.
Mirum delivered Q4 2025 total revenue of $148.9 million (+50% YoY) with full-year net product sales of $521.3 million (+55%). Q4 net loss was $5.7 million ($0.47 per share), narrowed from $23.8 million a year ago. LIVMARLI full-year sales were $360.0 million (+69% U.S.) and bile acid medicines $161.3 million (+31%). Management guides 2026 global net product sales of approximately $630–650 million.
- Q4 product revenue $148.9M; FY net product sales $521.3M (+55%).
- LIVMARLI FY sales $360.0M; bile acid medicines $161.3M.
- Q4 net loss narrowed to $5.7M ($0.47 EPS).
- 2026 global net product sales guide $630–650M.
Headline financials
Revenue & EPS history
Mirum Pharmaceuticals · Revenue · Quarterly
$149M
Revenue by segment
Mirum Pharmaceuticals · $29.1M total across 1 segment · Q1 2023
- Net Product Sales$29.1M—100.0%
Forward guidance
Mirum expects 2026 global net product sales of approximately $630–650 million, driven by LIVMARLI and bile acid franchise growth and upcoming readouts from the LIVMARLI EXPAND program.
Tailwinds
- Rare disease portfolio scaling with improving operating leverage.
- Strong LIVMARLI U.S. growth and label expansion opportunities.
- 2026 guidance implies continued double-digit revenue growth.
Headwinds
- Still near breakeven on GAAP basis with elevated SG&A.
- Pipeline timing risk on EXPAND topline (expected Q4 2026).
- Payer access and competitive dynamics in cholestatic liver diseases.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2025
+1.7%
Avg return
Earnings day
+0.3%
Avg return
5 days after
+2.9%
Avg return
30 days after
59%
16 / 27 earnings
Positive
+26.4%
Q2 2022
Best reaction
-16.2%
Q3 2022
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +4.0% | +0.2% | -11.7% | |
| Q4 2025 | -15.1% | -19.2% | -18.6% | |
| Q3 2025 | -1.4% | -1.8% | -3.5% | |
| Q1 2025 | +9.9% | +9.8% | +12.5% | |
| Q4 2024 | -7.0% | -10.5% | -9.0% | |
| Q3 2024 | +5.6% | +6.9% | +1.6% | |
| Q2 2024 | +1.8% | +14.3% | +5.0% | |
| Q1 2024 | -0.3% | -4.4% | -3.2% | |
| Q4 2023 | -3.0% | -3.1% | -15.2% | |
| Q3 2023 | +5.6% | +5.6% | +12.6% | |
| Q2 2023 | +6.1% | +2.1% | +6.1% | |
| Q1 2023 | -8.3% | -7.9% | -7.9% | |
| Q4 2022 | -1.1% | -4.7% | +5.1% | |
| Q3 2022 | -16.2% | -19.7% | -24.1% | |
| Q2 2022 | +26.4% | +18.0% | +7.4% | |
| Q1 2022 | +7.1% | -4.4% | +7.0% | |
| Q4 2021 | +3.3% | +1.5% | +29.5% | |
| Q3 2021 | +0.1% | -1.2% | -7.9% | |
| Q2 2021 | +0.5% | -4.0% | +23.0% | |
| Q1 2021 | -1.4% | -6.3% | -10.8% | |
| Q4 2020 | +6.0% | +14.3% | +10.2% | |
| Q3 2020 | +11.6% | +16.9% | +48.0% | |
| Q2 2020 | +13.0% | +15.3% | -4.3% | |
| Q1 2020 | +0.1% | +6.2% | +10.8% | |
| Q4 2019 | +8.1% | -10.5% | +25.7% | |
| Q3 2019 | -0.1% | +4.0% | +22.6% | |
| Q2 2019 | -9.0% | -10.3% | -31.5% | |
| Q1 2019 | — | — | — | |
| Q4 2018 | — | — | — | |
| Q3 2018 | — | — | — |
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