NASDAQ$IOVA

Iovance Biotherapeutics Inc. · Q4 2025 earnings

Q4 2025 earnings · · Before market open · Investor relations

Briefing

Iovance Biotherapeutics reported Q4 2025, revenue of $87M, net loss of $71.9M.

For Q4 2025, Iovance Biotherapeutics reported revenue of $87M, a net loss of $71.9M. Management discusses segment performance, capital allocation, and outlook in the earnings release.

  • Revenue $87M.
  • Net loss $71.9M.
  • Iovance Biotherapeutics highlights liquidity, operations, and 2026 priorities.

Headline financials

Total Revenue

$87M

Previous: $73.7M+18.0%
EPS (adj)

-$0.18

Previous: -$0.26+30.8%
Net Loss Per Share

-$0.18

Previous: -$0.26+30.8%
Total Product Revenue

$86.8M

Previous: $73.7M+17.7%
Research and Development Expenses

$71.2M

No prior period
Selling, General and Administrative Expenses

$36.4M

No prior period
Cash, Cash Equivalents and Investments

$303M

No prior period
Manufacturing Turnaround Time (Days)

32

No prior period
Net Income

-$71.9M

Previous: -$78.6M+8.5%
Operating Income

-$73.5M

Previous: -$86.6M+15.1%
Gross Profit

$43.6M

No prior period

Revenue & EPS history

Iovance · Revenue · Quarterly

$87M

Q4 2025+18%vs Q4 2024
Beat estimate in 4 of 12 quarters(33%)
ActualEstimate

Forward guidance

The release discusses Iovance Biotherapeutics's outlook for upcoming periods, including capital allocation, operating priorities, and market risks, without relying solely on numeric EPS bridges.

Tailwinds

  • Iovance Biotherapeutics cites operational execution and demand trends supporting the outlook.
  • Balance sheet and liquidity actions aim to fund growth and returns.

Headwinds

  • GAAP profitability remained under pressure in Q4 2025.
  • Macro, pricing, and input-cost volatility could pressure margins.
  • Segment mix and one-time items may affect quarter-to-quarter comparability.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 20 quarterly earnings reports · overlaid with Q4 2025

Historical avgQ4 2025

-1.0%

Avg return

Earnings day

+2.1%

Avg return

5 days after

-1.2%

Avg return

30 days after

37%

20 / 54 earnings

Positive

+36.3%

Q4 2019

Best reaction

-45.1%

Q1 2025

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q1 2026-13.2%-12.7%+3.4%
Q4 2025+30.1%+33.6%+27.7%
Q3 2025+27.9%+46.4%+21.5%
Q1 2025-45.1%-46.1%-35.3%
Q4 2024-19.4%-23.0%-32.3%
Q3 2024-12.8%-20.2%-25.6%
Q2 2024+35.3%+46.5%+36.6%
Q1 2024-18.1%-19.9%-41.9%
Q4 2023-8.9%+72.3%+67.9%
Q3 2023-3.5%-8.1%+55.8%
Q2 2023+7.8%+0.1%-17.7%
Q1 2023+7.9%+5.5%+13.0%
Q4 2022+1.8%+2.5%-14.2%
Q3 2022+0.0%-7.0%-23.1%
Q2 2022+1.2%-0.2%-8.8%
Q1 2022-12.4%-17.2%-52.4%
Q4 2021+10.2%+9.4%+20.5%
Q3 2021+0.6%-0.2%-33.4%
Q2 2021+3.2%+2.1%+10.1%
Q1 2021-2.4%-9.3%-38.7%
Q4 2020-5.4%-5.3%-27.3%
Q3 2020+2.2%-3.7%+8.9%
Q2 2020-5.3%-8.8%-0.7%
Q1 2020+1.2%+12.0%-4.3%
Q4 2019+36.3%+33.3%+29.4%
Q3 2019-0.7%+7.5%+12.5%
Q2 2019-3.5%-8.6%-14.6%
Q1 2019-5.5%-3.2%+61.2%
Q4 2018-1.7%+7.8%-9.0%
Q3 2018-3.2%-5.1%+5.3%
Q2 2018+6.9%+6.5%+23.3%
Q1 2018+0.7%+1.0%-16.2%
Q4 2017-8.6%-11.8%-21.2%
Q3 2017-6.5%+2.0%+18.3%
Q2 2017-5.1%-4.3%-1.7%
Q1 2017-9.8%-11.7%-24.8%
Q4 2016-1.3%+2.7%-10.1%
Q3 2016+5.1%+19.7%+2.6%
Q2 2016-2.1%-1.5%-11.1%
Q1 2016+4.4%
Q4 2015-5.4%
Q3 2015
Q4 2014+18.7%
Q1 2013-2.8%
Q2 2013-2.8%
Q4 2012+0.0%
Q3 2012-20.0%
Q2 2012-26.0%
Q1 2012+2.6%
Q4 2011-0.9%
Q3 2011-0.8%
Q2 2011-7.1%
Q1 2011+6.1%
Q4 2010+0.0%
Q3 2010-4.5%
Q2 2010
Q1 2010

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