NASDAQ$GBIO
Generation Bio Co · Q4 2022 earnings
Q4 2022 earnings · · Investor relations
Briefing
Generation Bio reported its Q4 2022 financial results and outlined strategic priorities for 2023.
Generation Bio reported a net loss of $32.4 million for the fourth quarter of 2022. The company's cash, cash equivalents, and marketable securities were $279.1 million as of December 31, 2022, which is expected to fund operations into 2025. The company is focusing on achieving proof-of-concept for its ctLNP delivery systems in 2023.
- Cash, cash equivalents and marketable securities were $279.1 million as of December 31, 2022.
- R&D expenses were $21.6 million for the quarter ended December 31, 2022.
- G&A expenses were $13.1 million for the quarter ended December 31, 2022.
- Net loss was $32.4 million, or $0.55 basic and diluted net loss per share, for the quarter ended December 31, 2022.
Headline financials
Revenue & EPS history
Generation Bio · Revenue · Quarterly
$1.59M
Revenue by segment
Generation Bio · $2.15M total across 1 segment · Q3 2023
- Collaboration revenue$2.15M—100.0%
Forward guidance
Generation Bio is focused on advancing its non-viral DNA therapeutics platform and expects to demonstrate Factor VIII expression in non-human primates in 2023.
Tailwinds
- Demonstrate Factor VIII expression in non-human primates (NHPs) with a novel ctLNP.
- Pursue development of two types of ctLNP delivery systems.
- GalNAc-conjugated ctLNP designed for highly specific uptake by hepatocytes.
- Developing a “stealth” LNP, designed to avoid clearance by the spleen and liver.
- Demonstrate proof-of-concept for re-targeting its stealth LNP system to reach immune cells
Headwinds
- Uncertainties inherent in the identification and development of product candidates
- Uncertainties as to the availability and timing of results from preclinical studies and clinical trials
- Uncertainties regarding the RES manufacturing process
- Challenges in the manufacture of genetic medicine products
- Impact of the COVID-19 pandemic on the company’s business and operations
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 12 quarterly earnings reports · overlaid with Q4 2022
+3.8%
Avg return
Earnings day
+5.9%
Avg return
5 days after
+8.6%
Avg return
30 days after
43%
10 / 23 earnings
Positive
+61.7%
Q2 2025
Best reaction
-19.7%
Q1 2022
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q4 2025 | — | — | — | |
| Q3 2025 | -3.3% | +11.0% | +2.7% | |
| Q2 2025 | +61.7% | +62.0% | +46.9% | |
| Q1 2025 | +4.5% | +0.4% | +4.0% | |
| Q4 2024 | -3.7% | -14.3% | -9.5% | |
| Q3 2024 | +8.7% | -0.5% | -40.8% | |
| Q2 2024 | -2.0% | -3.7% | -10.2% | |
| Q1 2024 | +18.4% | +16.4% | +1.9% | |
| Q4 2023 | +3.1% | +11.5% | +39.4% | |
| Q3 2023 | -1.7% | +7.7% | +46.2% | |
| Q2 2023 | -5.3% | -7.0% | +6.8% | |
| Q1 2023 | -5.0% | -2.7% | +0.4% | |
| Q4 2022 | -8.4% | -10.0% | +15.5% | |
| Q3 2022 | +12.2% | — | — | |
| Q2 2022 | +7.7% | — | — | |
| Q1 2022 | -19.7% | — | — | |
| Q4 2021 | +21.1% | — | — | |
| Q3 2021 | -1.5% | — | — | |
| Q2 2021 | -6.2% | — | — | |
| Q1 2021 | +0.3% | — | — | |
| Q4 2020 | -0.9% | — | — | |
| Q3 2020 | +8.5% | — | — | |
| Q4 2019 | -0.5% | — | — | |
| Q2 2020 | -0.5% | — | — | |
| Q1 2020 | — | — | — | |
| Q3 2019 | — | — | — | |
| Q2 2019 | — | — | — | |
| Q1 2019 | — | — | — |
Discussion
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