NASDAQ$EXEL
Exelixis Inc · Q4 2021 earnings
Q4 2021 earnings · · Investor relations
Briefing
Exelixis reported strong Q4 2021 financial results, driven by cabozantinib franchise performance and pipeline advancements.
Exelixis announced fourth quarter and full year 2021 financial results, with total revenues of $451.1 million for the fourth quarter and $1.43 billion for the full year. The cabozantinib franchise achieved significant milestones, including $1.08 billion in U.S. net product revenues for the full year, with $302.7 million for the fourth quarter. GAAP diluted EPS was $0.29 for the fourth quarter and $0.72 for the full year. The company is also advancing its clinical pipeline and discovery programs.
- Total revenues for Q4 2021 were $451.1 million, compared to $270.1 million for Q4 2020.
- Cabozantinib franchise net product revenues in the U.S. were $302.7 million for Q4 2021.
- GAAP diluted EPS for Q4 2021 was $0.29, and non-GAAP diluted EPS was $0.35.
- Exelixis is progressing its clinical pipeline and discovery programs, with multiple key milestones achieved in late 2021 and early 2022.
Headline financials
Revenue & EPS history
Exelixis · Revenue · Quarterly
$451M
Revenue by segment
Exelixis · $436M total across 3 segments · Q4 2021
- CABOMETYX Net Product Revenue$295M—67.7%
- Collaboration Revenues$133M—30.5%
- COMETRIQ Net Product Revenue$7.6M—1.7%
Forward guidance
Exelixis provided financial guidance for fiscal year 2022, including total revenues between $1.525 billion and $1.625 billion.
Tailwinds
- Multiple pivotal clinical trial readouts for cabozantinib across the COSMIC and CONTACT clinical studies
- Launch of the XL092 phase 3 pivotal trial program
- Expansion of the ongoing phase 1b STELLAR-001/-002 clinical trials of XL092, with plans to provide clinical updates
- Accelerated development and expansion of the XB002 clinical program, with plans to provide clinical updates from the ongoing phase 1 study
- Progression of up to five new development candidates into preclinical development from the company’s more than 10 discovery programs currently advancing through internal and collaborative efforts.
Headwinds
- The continuing COVID-19 pandemic and its impact on Exelixis’ clinical trial, drug discovery and commercial activities
- The degree of market acceptance of CABOMETYX and other Exelixis products in the indications for which they are approved and in the territories where they are approved, and Exelixis’ and its partners’ ability to obtain or maintain coverage and reimbursement for these products
- The effectiveness of CABOMETYX and other Exelixis products in comparison to competing products
- The level of costs associated with Exelixis’ commercialization, research and development, in-licensing or acquisition of product candidates, and other activities
- Market competition, including the potential for competitors to obtain approval for generic versions of Exelixis’ marketed products
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2021
+0.5%
Avg return
Earnings day
+2.7%
Avg return
5 days after
+3.6%
Avg return
30 days after
48%
31 / 65 earnings
Positive
+25.5%
Q3 2018
Best reaction
-12.0%
Q4 2010
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +3.7% | +11.9% | +18.6% | |
| Q4 2025 | -0.1% | +2.2% | -4.0% | |
| Q3 2025 | +6.5% | +9.3% | +17.0% | |
| Q1 2025 | +20.7% | +20.9% | +12.6% | |
| Q4 2024 | -0.0% | +6.7% | +11.7% | |
| Q3 2024 | +13.8% | +19.7% | +26.1% | |
| Q2 2024 | +12.8% | +14.7% | +8.7% | |
| Q1 2024 | -7.6% | -7.7% | -12.4% | |
| Q4 2023 | -5.7% | -5.5% | +3.2% | |
| Q3 2023 | -2.2% | +1.2% | +6.6% | |
| Q2 2023 | +3.2% | +2.8% | +13.6% | |
| Q1 2023 | +1.8% | +0.8% | +1.7% | |
| Q4 2022 | +2.8% | +1.6% | -3.5% | |
| Q3 2022 | +2.6% | -0.7% | +2.8% | |
| Q2 2022 | -9.5% | -9.6% | -17.4% | |
| Q1 2022 | +2.6% | +3.8% | -2.4% | |
| Q4 2021 | +2.5% | +2.7% | +12.1% | |
| Q3 2021 | -11.3% | -10.8% | -24.1% | |
| Q2 2021 | +2.7% | +2.5% | +17.7% | |
| Q1 2021 | +4.8% | +3.0% | -6.7% | |
| Q4 2020 | -3.8% | -4.5% | +1.4% | |
| Q3 2020 | -8.3% | -6.0% | -16.0% | |
| Q2 2020 | -3.0% | -6.0% | -10.3% | |
| Q1 2020 | +2.2% | +1.4% | -11.9% | |
| Q4 2019 | -7.4% | -7.9% | -14.4% | |
| Q3 2019 | -8.8% | -5.0% | -1.8% | |
| Q2 2019 | -3.8% | -6.7% | -6.4% | |
| Q1 2019 | +2.7% | +5.0% | -0.4% | |
| Q4 2018 | +5.1% | +6.1% | +18.0% | |
| Q3 2018 | +25.5% | +22.3% | +46.4% | |
| Q2 2018 | +8.2% | +1.2% | -9.2% | |
| Q1 2018 | +5.8% | +5.8% | -2.0% | |
| Q4 2017 | -8.1% | -18.4% | -24.2% | |
| Q3 2017 | +2.9% | +10.4% | +13.4% | |
| Q2 2017 | -2.9% | +0.8% | +9.5% | |
| Q1 2017 | +3.4% | -3.2% | -16.5% | |
| Q4 2016 | -0.7% | +6.4% | -2.6% | |
| Q3 2016 | +10.2% | +15.4% | +60.7% | |
| Q2 2016 | +21.0% | +19.5% | +26.1% | |
| Q1 2016 | +0.4% | — | — | |
| Q4 2015 | -0.5% | — | — | |
| Q3 2015 | -5.9% | — | — | |
| Q2 2015 | -2.2% | — | — | |
| Q1 2015 | +3.3% | — | — | |
| Q4 2014 | -2.2% | — | — | |
| Q3 2014 | +0.0% | — | — | |
| Q2 2014 | -1.9% | — | — | |
| Q1 2014 | -6.2% | — | — | |
| Q4 2013 | -2.2% | — | — | |
| Q3 2013 | -7.6% | — | — | |
| Q2 2013 | -4.4% | — | — | |
| Q1 2013 | +6.3% | — | — | |
| Q4 2012 | -6.6% | — | — | |
| Q3 2012 | -6.1% | — | — | |
| Q2 2012 | -7.5% | — | — | |
| Q1 2012 | -3.8% | — | — | |
| Q1 2011 | -3.8% | — | — | |
| Q4 2011 | +2.5% | — | — | |
| Q4 2009 | +2.5% | — | — | |
| Q3 2011 | +3.8% | — | — | |
| Q3 2010 | +3.8% | — | — | |
| Q2 2011 | -12.0% | — | — | |
| Q4 2010 | -12.0% | — | — | |
| Q2 2010 | -5.2% | — | — | |
| Q1 2010 | +17.9% | — | — |
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