NASDAQ$EXEL
Exelixis Inc · Q2 2025 earnings
Q2 2025 earnings · · After market close · Investor relations
Briefing
Exelixis reported strong Q2 2025 product revenue growth driven by CABOMETYX demand in RCC and NET indications.
Exelixis achieved total revenues of $568.3 million in Q2 2025, including $520.0 million in net product revenues, with net income of $184.8 million. Operating income reached $213.6 million despite lower collaboration revenues compared to the prior year. The company continued advancing its pipeline with zanzalintinib while maintaining a solid cash position of $164.4 million.
- Net product revenues grew 19% year-over-year to $520.0 million, led by CABOMETYX sales of $517.9 million.
- Net income of $184.8 million reflected a 20% operating margin supported by disciplined R&D and SG&A spending.
- U.S. revenues accounted for 92% of total revenues at $524.8 million, with international collaboration revenues declining due to milestone timing.
- Cash and cash equivalents stood at $164.4 million with continued share repurchases totaling over $796 million year-to-date.
Headline financials
Revenue & EPS history
Exelixis · Revenue · Quarterly
$568M
Revenue by segment
Exelixis · $568M total across 3 segments · Q2 2025
- CABOMETYX$518M—91.1%
- Collaboration revenues$48.2M—8.5%
- COMETRIQ$2.12M—0.4%
Forward guidance
No explicit quantitative guidance provided in the filing.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports
+0.5%
Avg return
Earnings day
+2.7%
Avg return
5 days after
+3.6%
Avg return
30 days after
48%
31 / 65 earnings
Positive
+25.5%
Q3 2018
Best reaction
-12.0%
Q4 2010
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q2 2025 | — | — | — | |
| Q1 2026 | +3.7% | +11.9% | +18.6% | |
| Q4 2025 | -0.1% | +2.2% | -4.0% | |
| Q3 2025 | +6.5% | +9.3% | +17.0% | |
| Q1 2025 | +20.7% | +20.9% | +12.6% | |
| Q4 2024 | -0.0% | +6.7% | +11.7% | |
| Q3 2024 | +13.8% | +19.7% | +26.1% | |
| Q2 2024 | +12.8% | +14.7% | +8.7% | |
| Q1 2024 | -7.6% | -7.7% | -12.4% | |
| Q4 2023 | -5.7% | -5.5% | +3.2% | |
| Q3 2023 | -2.2% | +1.2% | +6.6% | |
| Q2 2023 | +3.2% | +2.8% | +13.6% | |
| Q1 2023 | +1.8% | +0.8% | +1.7% | |
| Q4 2022 | +2.8% | +1.6% | -3.5% | |
| Q3 2022 | +2.6% | -0.7% | +2.8% | |
| Q2 2022 | -9.5% | -9.6% | -17.4% | |
| Q1 2022 | +2.6% | +3.8% | -2.4% | |
| Q4 2021 | +2.5% | +2.7% | +12.1% | |
| Q3 2021 | -11.3% | -10.8% | -24.1% | |
| Q2 2021 | +2.7% | +2.5% | +17.7% | |
| Q1 2021 | +4.8% | +3.0% | -6.7% | |
| Q4 2020 | -3.8% | -4.5% | +1.4% | |
| Q3 2020 | -8.3% | -6.0% | -16.0% | |
| Q2 2020 | -3.0% | -6.0% | -10.3% | |
| Q1 2020 | +2.2% | +1.4% | -11.9% | |
| Q4 2019 | -7.4% | -7.9% | -14.4% | |
| Q3 2019 | -8.8% | -5.0% | -1.8% | |
| Q2 2019 | -3.8% | -6.7% | -6.4% | |
| Q1 2019 | +2.7% | +5.0% | -0.4% | |
| Q4 2018 | +5.1% | +6.1% | +18.0% | |
| Q3 2018 | +25.5% | +22.3% | +46.4% | |
| Q2 2018 | +8.2% | +1.2% | -9.2% | |
| Q1 2018 | +5.8% | +5.8% | -2.0% | |
| Q4 2017 | -8.1% | -18.4% | -24.2% | |
| Q3 2017 | +2.9% | +10.4% | +13.4% | |
| Q2 2017 | -2.9% | +0.8% | +9.5% | |
| Q1 2017 | +3.4% | -3.2% | -16.5% | |
| Q4 2016 | -0.7% | +6.4% | -2.6% | |
| Q3 2016 | +10.2% | +15.4% | +60.7% | |
| Q2 2016 | +21.0% | +19.5% | +26.1% | |
| Q1 2016 | +0.4% | — | — | |
| Q4 2015 | -0.5% | — | — | |
| Q3 2015 | -5.9% | — | — | |
| Q2 2015 | -2.2% | — | — | |
| Q1 2015 | +3.3% | — | — | |
| Q4 2014 | -2.2% | — | — | |
| Q3 2014 | +0.0% | — | — | |
| Q2 2014 | -1.9% | — | — | |
| Q1 2014 | -6.2% | — | — | |
| Q4 2013 | -2.2% | — | — | |
| Q3 2013 | -7.6% | — | — | |
| Q2 2013 | -4.4% | — | — | |
| Q1 2013 | +6.3% | — | — | |
| Q4 2012 | -6.6% | — | — | |
| Q3 2012 | -6.1% | — | — | |
| Q2 2012 | -7.5% | — | — | |
| Q1 2012 | -3.8% | — | — | |
| Q1 2011 | -3.8% | — | — | |
| Q4 2009 | +2.5% | — | — | |
| Q4 2011 | +2.5% | — | — | |
| Q3 2011 | +3.8% | — | — | |
| Q3 2010 | +3.8% | — | — | |
| Q2 2011 | -12.0% | — | — | |
| Q4 2010 | -12.0% | — | — | |
| Q2 2010 | -5.2% | — | — | |
| Q1 2010 | +17.9% | — | — |
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