NASDAQ$BPMC

Blueprint Medicines Corp · Q4 2023 earnings

Q4 2023 earnings · · Investor relations

Briefing

Blueprint Medicines reported Q4 2023 results, with AYVAKIT net product revenues reaching $71.0 million and full-year revenues of $204.2 million. The company anticipates significant growth in 2024, driven by the launch in ISM and expansion in the U.S. and Europe.

Blueprint Medicines reported Q4 2023 revenues of $72.0 million, including $71.0 million from AYVAKIT net product revenues. The company anticipates global AYVAKIT net product revenue of approximately $360 million to $390 million in 2024.

  • AYVAKIT net product revenues reached $71.0 million in Q4 2023.
  • The European Commission approved AYVAKYT as the first and only treatment for indolent systemic mastocytosis (ISM).
  • The company advanced the development of BLU-222 in combination with ribociclib and fulvestrant in patients with HR+/HER2- breast cancer.
  • Blueprint Medicines anticipates global AYVAKIT net product revenue of approximately $360 million to $390 million in 2024.

Headline financials

Total Revenue

$72M

Previous: $38.8M+85.5%
EPS (adj)

-$1.82

Previous: -$2.65+31.3%
R&D Expenses

$97.5M

No prior period
SG&A Expenses

$79.3M

No prior period
Capital Expenditures

-$4.67M

Previous: $1.48M-415.5%
Net Income

-$111M

Previous: -$159M+30.1%
Operating Income

-$105M

No prior period
Gross Profit

$71.7M

Previous: $33.9M+111.3%
R&D Expense

$96M

No prior period
Stock-Based Comp

$22.6M

Previous: $26.1M-13.5%

Revenue & EPS history

Blueprint Medicines · Revenue · Quarterly

$72M

Q4 2023+85.5%vs Q4 2022
Beat estimate in 12 of 14 quarters(86%)
ActualEstimate

Forward guidance

Blueprint Medicines anticipates approximately $360 million to $390 million in global AYVAKIT net product revenues for all approved indications in 2024. The midpoint of this range represents more than 80 percent year-over-year revenue growth, the majority of which is expected to be driven by ISM.

Tailwinds

  • Global AYVAKIT net product revenues are expected to be between $360 million and $390 million.
  • Revenue growth is expected to be more than 80 percent year-over-year.
  • ISM is expected to be the primary driver of revenue growth.
  • Operating expenses and cash burn are expected to decline in 2024.
  • Existing cash, cash equivalents, and investments, together with anticipated future product revenues, will maintain a durable capital position.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 16 quarterly earnings reports · overlaid with Q4 2023

Historical avgQ4 2023

+2.5%

Avg return

Earnings day

+2.6%

Avg return

5 days after

+6.3%

Avg return

30 days after

68%

27 / 40 earnings

Positive

+24.7%

Q3 2023

Best reaction

-20.7%

Q2 2023

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q2 2025
Q1 2025+10.9%+11.0%+13.3%
Q4 2025-8.1%-10.9%-13.4%
Q3 2025+4.9%+10.2%+14.0%
Q2 2024-10.7%-14.4%-11.8%
Q1 2024+13.0%+14.3%+11.2%
Q4 2023+17.5%+18.9%+17.9%
Q3 2023+24.7%+34.1%+55.8%
Q2 2023-20.7%-26.6%-21.2%
Q1 2023+8.4%+4.5%+12.1%
Q4 2022+5.0%-1.2%+2.4%
Q3 2022-11.1%-19.0%-8.5%
Q2 2022+18.0%+34.7%+46.0%
Q1 2022+5.9%-4.9%-4.8%
Q4 2021-17.0%-19.9%-21.9%
Q3 2021+7.9%+6.4%-3.1%
Q2 2021+6.0%+3.8%+13.2%
Q1 2021-1.0%
Q4 2020+3.8%
Q3 2020-2.2%
Q2 2020-0.8%
Q1 2020+0.7%
Q4 2019+3.5%
Q3 2019+10.4%
Q2 2019-9.2%
Q1 2019+9.0%
Q4 2018+1.4%
Q3 2018-1.4%
Q1 2018+1.3%
Q4 2017+5.5%
Q3 2017+4.8%
Q2 2017-9.8%
Q1 2017-11.6%
Q4 2016+13.0%
Q3 2016+9.9%
Q2 2016+2.4%
Q1 2016-1.4%
Q4 2015+4.6%
Q3 2015+1.4%
Q2 2015+2.5%
Q1 2015+8.4%
Q4 2014
Q3 2014
Q2 2014
Q1 2014

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