NYSE$CRL
Charles River Laboratories International Inc · Q4 2025 earnings
Q4 2025 earnings · · Before market open · Investor relations
Briefing
Charles River Laboratories reported Q4 2025 revenue of $994.2M with a GAAP loss of $(5.62) per share and non-GAAP EPS of $2.39.
Fourth quarter revenue was $994.2 million (down 0.8% reported, down 2.6% organic). GAAP net loss was $276.6 million ($(5.62) per share) on intangible and goodwill impairments; non-GAAP net income was $118.8 million ($2.39 per share). Management issued 2026 non-GAAP EPS guidance of $10.70–$11.20 on stabilizing DSA bookings.
- Q4 revenue $994.2M; organic revenue down 2.6%.
- Non-GAAP EPS $2.39; GAAP loss $(5.62) on impairments.
- DSA Q4 net bookings improved; Manufacturing non-GAAP margin 32.1%.
- 2026 non-GAAP EPS guide $10.70–$11.20.
Headline financials
Revenue & EPS history
Charles River Labs · Revenue · Quarterly
$994M
Revenue by segment
Charles River Labs · $1.03B total across 3 segments · Q3 2023
- Discovery & Safety Assessment$664M+7.2%64.7%
- Research Models & Services$187M+3.7%18.2%
- Manufacturing Solutions$176M-7.3%17.1%
Forward guidance
2026 guidance assumes flat to +1.5% reported revenue with organic revenue down 1% to flat, driven by DSA recovery and Manufacturing growth partially offset by RMS headwinds.
Tailwinds
- Fourth-quarter DSA net bookings strengthened materially.
- Non-GAAP operating margin 18.1% despite revenue pressure.
- K.F. Cambodia acquisition and cost actions support 2026 EPS growth.
Headwinds
- GAAP losses from Biologics and Cell Solutions impairments.
- Organic revenue still declined in Q4.
- Planned divestitures (~7% of revenue) add transition risk.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2025
+0.1%
Avg return
Earnings day
+0.5%
Avg return
5 days after
+0.7%
Avg return
30 days after
47%
32 / 68 earnings
Positive
+18.4%
Q1 2025
Best reaction
-13.3%
Q3 2017
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +1.8% | -9.0% | -0.1% | |
| Q4 2025 | -1.8% | +3.1% | -3.1% | |
| Q3 2025 | -5.5% | -5.0% | +3.6% | |
| Q1 2025 | +18.4% | +24.0% | +25.4% | |
| Q4 2024 | +6.9% | +10.4% | +8.3% | |
| Q3 2024 | +11.5% | +17.0% | +1.7% | |
| Q2 2024 | -11.7% | -15.1% | -17.8% | |
| Q1 2024 | -3.0% | -1.0% | -8.7% | |
| Q4 2023 | +11.4% | +11.2% | +17.6% | |
| Q3 2023 | -7.3% | -7.0% | +11.8% | |
| Q2 2023 | +5.5% | +5.2% | -3.2% | |
| Q1 2023 | +2.7% | +1.0% | +6.1% | |
| Q4 2022 | -6.7% | -9.0% | -20.4% | |
| Q3 2022 | +4.8% | +9.0% | +7.4% | |
| Q2 2022 | -6.6% | -9.4% | -17.8% | |
| Q1 2022 | -1.2% | -8.9% | -3.3% | |
| Q4 2021 | -6.7% | -6.1% | -8.3% | |
| Q3 2021 | -12.2% | -13.4% | -17.3% | |
| Q2 2021 | -0.3% | -0.4% | +9.3% | |
| Q1 2021 | +4.0% | +3.2% | -0.1% | |
| Q4 2020 | +2.0% | -1.1% | -0.0% | |
| Q3 2020 | +2.6% | +7.0% | +3.7% | |
| Q2 2020 | +6.8% | +7.3% | +0.4% | |
| Q1 2020 | +11.1% | +12.0% | +24.2% | |
| Q4 2019 | +8.6% | +11.9% | -21.3% | |
| Q3 2019 | -2.5% | +1.1% | +12.0% | |
| Q2 2019 | -5.1% | -10.3% | -7.0% | |
| Q1 2019 | -4.2% | -4.1% | -10.4% | |
| Q4 2018 | +8.1% | +9.0% | +11.1% | |
| Q3 2018 | +8.8% | +6.8% | +3.0% | |
| Q2 2018 | -5.2% | -6.6% | -1.6% | |
| Q1 2018 | +0.3% | -1.0% | +8.5% | |
| Q4 2017 | +8.2% | +6.0% | +9.9% | |
| Q3 2017 | -13.3% | -14.3% | -11.9% | |
| Q2 2017 | -1.7% | -0.2% | +10.0% | |
| Q1 2017 | -3.8% | -2.3% | +2.8% | |
| Q4 2016 | +7.6% | +7.3% | +8.4% | |
| Q3 2016 | -9.0% | -5.1% | -3.0% | |
| Q2 2016 | -0.0% | -3.1% | -3.0% | |
| Q1 2016 | +2.5% | — | — | |
| Q4 2015 | +3.9% | — | — | |
| Q3 2015 | +5.7% | — | — | |
| Q2 2015 | +1.4% | — | — | |
| Q1 2015 | -8.8% | — | — | |
| Q4 2014 | +6.3% | — | — | |
| Q3 2014 | -1.9% | — | — | |
| Q2 2014 | +6.0% | — | — | |
| Q1 2014 | -6.6% | — | — | |
| Q4 2013 | -1.6% | — | — | |
| Q3 2013 | -1.2% | — | — | |
| Q2 2013 | +3.4% | — | — | |
| Q1 2013 | -3.9% | — | — | |
| Q4 2012 | +0.9% | — | — | |
| Q3 2012 | -5.3% | — | — | |
| Q2 2012 | +2.3% | — | — | |
| Q1 2012 | +1.8% | — | — | |
| Q4 2010 | -1.3% | — | — | |
| Q4 2011 | -1.3% | — | — | |
| Q3 2011 | -5.0% | — | — | |
| Q2 2011 | -9.4% | — | — | |
| Q1 2010 | -2.4% | — | — | |
| Q1 2011 | -0.1% | — | — | |
| Q4 2008 | -0.9% | — | — | |
| Q3 2010 | -4.4% | — | — | |
| Q3 2009 | -4.4% | — | — | |
| Q2 2010 | +3.6% | — | — | |
| Q4 2009 | +3.6% | — | — | |
| Q2 2009 | +3.6% | — | — |
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