NYSE$ANVS
Annovis Bio · Q1 2026 earnings
Q1 2026 earnings · · Investor relations
Briefing
Annovis Bio reported a net loss of $17.6 million for the first quarter of 2026, driven by increased research and development spending on its Phase 3 Alzheimer's trial.
Annovis Bio, a clinical-stage biopharmaceutical company, posted a significantly higher net loss in Q1 2026 compared to the prior year as it advanced its pivotal Phase 3 trial in early Alzheimer's disease. Operating expenses rose sharply to $18.0 million, primarily from clinical trial costs, while the company maintained a cash position of $14.2 million. Management highlighted ongoing capital needs and plans for additional financing to support development of buntanetap.
- Net loss widened to $17.6 million from $5.5 million in Q1 2025 due to ramped-up clinical activities.
- Research and development expenses increased to $16.7 million, reflecting costs for the Phase 3 AD trial and PD open-label extension study.
- Cash and cash equivalents declined to $14.2 million, with the company stating runway into Q4 2026 pending additional capital raises.
- Company completed equity raises via ATM and subsequent underwritten offering, raising net proceeds to fund ongoing neurodegeneration programs.
Headline financials
Revenue & EPS history
Annovis Bio · Revenue · Quarterly
$0
Forward guidance
Company expects continued high operating cash burn through 2026 driven by Phase 3 AD trial completion and plans additional equity financings; cash runway stated through Q4 2026.
Tailwinds
- Phase 3 AD trial actively enrolling with screening completion targeted for May 2026
- FDA alignment achieved on development path for two potential NDAs
Headwinds
- Substantial doubt about going concern without additional capital
- No product revenue expected in the foreseeable future
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports · overlaid with Q1 2026
-1.9%
Avg return
Earnings day
+0.2%
Avg return
5 days after
+9.0%
Avg return
30 days after
35%
9 / 26 earnings
Positive
+41.0%
Q1 2024
Best reaction
-68.5%
Q2 2021
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | -5.1% | -7.0% | — | |
| Q4 2025 | -3.1% | -8.1% | -37.1% | |
| Q3 2025 | +15.5% | +43.6% | +95.7% | |
| Q2 2025 | -1.4% | -2.8% | -15.2% | |
| Q1 2025 | +6.6% | +18.9% | +66.3% | |
| Q4 2024 | -7.1% | -8.5% | +14.2% | |
| Q3 2024 | -7.6% | -16.2% | -27.0% | |
| Q2 2024 | +9.9% | +14.9% | +3.2% | |
| Q1 2024 | +41.0% | +40.1% | +2.5% | |
| Q4 2023 | -6.1% | -6.7% | -48.7% | |
| Q3 2023 | -0.3% | +3.1% | +76.9% | |
| Q2 2023 | -1.7% | -3.5% | -17.0% | |
| Q1 2023 | -5.8% | -8.5% | -9.1% | |
| Q4 2022 | -22.5% | -18.2% | -4.9% | |
| Q3 2022 | -4.1% | +1.1% | -3.3% | |
| Q2 2022 | +5.9% | +10.1% | -7.1% | |
| Q1 2022 | +9.9% | -3.3% | -1.3% | |
| Q4 2021 | -7.6% | -13.5% | +1.0% | |
| Q3 2021 | -0.9% | +21.3% | -30.4% | |
| Q2 2021 | -68.5% | -65.8% | -66.2% | |
| Q1 2021 | +5.8% | +30.1% | +188.3% | |
| Q4 2020 | -10.3% | -9.7% | -0.5% | |
| Q3 2020 | +3.8% | -1.1% | +28.7% | |
| Q2 2020 | -0.3% | -2.2% | -20.6% | |
| Q1 2020 | -0.8% | -3.0% | +21.9% | |
| Q4 2019 | +6.5% | +0.9% | +14.1% | |
| Q2 2019 | — | — | — | |
| Q1 2019 | — | — | — | |
| Q4 2018 | — | — | — | |
| Q3 2018 | — | — | — | |
| Q2 2018 | — | — | — | |
| Q1 2018 | — | — | — |
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