NASDAQ$ZYME

Zymeworks Inc · Q4 2025 earnings

Q4 2025 earnings · · Before market open · Investor relations

Briefing

ZYME reported Q4 2025, revenue of $106M, a net loss of $81.1M.

For Q4 2025, ZYME reported revenue of $106M, a net loss of $81.1M. Management discusses segment performance, capital allocation, and macro risks in the quarterly filing.

  • Revenue $106M.
  • Net loss $81.1M.
  • ZYME MD&A covers liquidity, operating priorities, and sector risks.

Headline financials

Total Revenue

$106M

Previous: $76.3M+38.9%
EPS (adj)

-$0.55

Previous: -$0.31-77.4%
Research & Development Expense

$31.2M

Previous: $37.1M-15.8%
General & Administrative Expense

$15.4M

Previous: $16.2M-4.7%
Total Operating Expenses

$46.7M

Previous: $53.2M-12.3%
Diluted EPS

-$0.55

Previous: -$0.31-77.4%
Basic Shares Outstanding

75.3M

Previous: 69.6M+8.2%
Diluted Shares Outstanding

75.3M

Previous: 69.6M+8.2%
Total Stockholders' Equity

$269M

Previous: $0.00
Net Income

-$81.1M

Previous: -$23.5M-245.0%
Operating Income

-$44.2M

Previous: -$23.5M-87.8%

Revenue & EPS history

Zymeworks · Revenue · Quarterly

$106M

Q4 2025+38.9%vs Q4 2024
Beat estimate in 3 of 4 quarters(75%)
ActualEstimate

Forward guidance

The quarterly filing discusses operating priorities, capital returns, and sector risks.

Tailwinds

  • MD&A highlights liquidity and core business trends.
  • Segment commentary supports the earnings narrative.

Headwinds

  • Macro or input-cost pressure may affect margins.
  • One-time items can affect YoY comparability.

Historical earnings impact

How earnings announcements have historically affected this stock's price.

Avg. return before/after earnings

Based on 13 quarterly earnings reports · overlaid with Q4 2025

Historical avgQ4 2025

-1.2%

Avg return

Earnings day

-0.4%

Avg return

5 days after

+7.6%

Avg return

30 days after

38%

5 / 13 earnings

Positive

+1.4%

Q1 2023

Best reaction

-8.0%

Q3 2025

Worst reaction

Earnings price reactions
QuarterReport dateReaction (Day 0)+5 days+30 days
Q1 2026-3.6%-13.5%-13.0%
Q4 2025+0.1%+3.4%+11.4%
Q3 2025-8.0%+8.2%+49.1%
Q1 2025-0.1%-0.6%+11.3%
Q4 2024-8.0%-11.2%-16.9%
Q3 2024+1.0%+1.2%+11.7%
Q2 2024+0.0%+4.3%+22.4%
Q1 2024+0.0%-8.3%-18.4%
Q4 2023+0.0%+1.6%+3.8%
Q3 2023+1.2%+0.1%+31.2%
Q3 2021+0.0%-1.3%+10.3%
Q2 2023+0.8%-3.6%-7.5%
Q1 2023+1.4%+14.1%+2.9%

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