NASDAQ$VRTX
Vertex Pharmaceuticals Incorporated · Q4 2025 earnings
Q4 2025 earnings · · After market close · Investor relations
Briefing
Vertex reported Q4 2025 total revenue of $3.19B with GAAP net income of $1.2B, or $4.65 per share.
Q4 total revenue increased 10% to $3.19 billion on continued CF performance and contributions from CASGEVY and JOURNAVX. GAAP net income was $1.2 billion ($4.65 diluted EPS); non-GAAP net income was $1.3 billion ($5.07 per share). FY25 revenue was $12.0 billion (+9%). 2026 total revenue guidance is $12.95B–$13.1B with $500M+ from non-CF products.
- Q4 revenue $3.19B (+10% YoY).
- GAAP net income $1.2B; non-GAAP EPS $5.07.
- FY25 revenue $12.0B.
- 2026 revenue guide $12.95B–$13.1B.
Headline financials
Revenue & EPS history
Vertex · Revenue · Quarterly
$3.19B
Revenue by segment
Vertex · $2.27B total across 1 segment · Q3 2023
- TRIKAFTA/KAFTRIO$2.27B+13.1%100.0%
Forward guidance
The release discusses VRTX's outlook for upcoming periods, including capital allocation, operating priorities, and market risks.
Tailwinds
- VRTX cites operational execution and demand trends supporting the outlook.
- Balance sheet and capital actions aim to fund growth and shareholder returns.
Headwinds
- Macro, pricing, and input-cost volatility could pressure margins.
- Segment mix and one-time items may affect quarter-to-quarter comparability.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2025
-0.3%
Avg return
Earnings day
-0.2%
Avg return
5 days after
+1.1%
Avg return
30 days after
46%
32 / 70 earnings
Positive
+6.1%
Q3 2024
Best reaction
-9.4%
Q1 2025
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | -1.2% | -0.1% | +3.0% | |
| Q4 2025 | +5.7% | +1.1% | +0.9% | |
| Q3 2025 | -1.1% | -3.9% | +7.4% | |
| Q2 2025 | +2.8% | -0.1% | +5.6% | |
| Q1 2025 | -9.4% | -15.0% | -11.3% | |
| Q4 2024 | -3.1% | -2.3% | +7.0% | |
| Q3 2024 | +6.1% | +9.7% | -1.5% | |
| Q2 2024 | +0.9% | +2.4% | -1.9% | |
| Q1 2024 | +2.3% | +5.4% | +20.4% | |
| Q4 2023 | -2.0% | -0.4% | -3.0% | |
| Q3 2023 | +0.5% | -0.7% | -6.0% | |
| Q2 2023 | -2.4% | -1.6% | -2.2% | |
| Q1 2023 | +1.6% | +2.2% | -5.0% | |
| Q4 2022 | -3.8% | -2.5% | -5.9% | |
| Q3 2022 | +0.9% | +1.0% | +0.6% | |
| Q2 2022 | +4.7% | +8.7% | +2.2% | |
| Q1 2022 | -7.2% | -12.3% | -1.6% | |
| Q4 2021 | +0.5% | +7.0% | +1.4% | |
| Q3 2021 | +2.0% | +4.0% | +10.3% | |
| Q2 2021 | -0.3% | -1.1% | -1.1% | |
| Q1 2021 | +2.2% | +0.6% | -2.3% | |
| Q4 2020 | -5.1% | -6.0% | -9.0% | |
| Q3 2020 | +0.0% | +1.3% | +8.8% | |
| Q2 2020 | -2.4% | -1.1% | -3.1% | |
| Q1 2020 | -2.2% | +3.0% | +12.1% | |
| Q4 2019 | -2.3% | +3.1% | -3.6% | |
| Q3 2019 | -1.2% | +0.8% | +12.1% | |
| Q2 2019 | +5.8% | +3.6% | +6.2% | |
| Q1 2019 | +0.0% | +0.8% | -1.3% | |
| Q4 2018 | -3.0% | -3.5% | -5.0% | |
| Q3 2018 | -4.9% | -2.2% | -7.9% | |
| Q2 2018 | +0.6% | -0.3% | +1.1% | |
| Q1 2018 | +0.6% | -1.7% | +1.5% | |
| Q4 2017 | +3.9% | -6.8% | +2.1% | |
| Q3 2017 | -4.9% | -1.0% | -3.0% | |
| Q2 2017 | -3.6% | -6.3% | -5.4% | |
| Q1 2017 | +1.7% | +1.8% | +3.1% | |
| Q4 2016 | +3.8% | +2.6% | +4.7% | |
| Q3 2016 | -0.0% | -1.5% | +10.9% | |
| Q2 2016 | +1.3% | +3.4% | +2.2% | |
| Q1 2016 | +3.1% | — | — | |
| Q4 2015 | +0.6% | — | — | |
| Q3 2015 | +4.3% | — | — | |
| Q2 2015 | +5.6% | — | — | |
| Q1 2015 | -1.7% | — | — | |
| Q4 2014 | -7.7% | — | — | |
| Q3 2014 | -1.5% | — | — | |
| Q2 2014 | -3.7% | — | — | |
| Q1 2014 | -2.0% | — | — | |
| Q4 2013 | +3.6% | — | — | |
| Q3 2013 | -7.8% | — | — | |
| Q2 2013 | +1.5% | — | — | |
| Q1 2013 | -1.9% | — | — | |
| Q4 2012 | -2.8% | — | — | |
| Q3 2012 | -6.8% | — | — | |
| Q2 2008 | -1.6% | — | — | |
| Q1 2012 | +2.5% | — | — | |
| Q4 2011 | +2.3% | — | — | |
| Q3 2011 | -0.7% | — | — | |
| Q2 2011 | +4.5% | — | — | |
| Q1 2011 | -1.8% | — | — | |
| Q4 2008 | -1.2% | — | — | |
| Q4 2010 | -1.2% | — | — | |
| Q3 2009 | -0.1% | — | — | |
| Q3 2010 | -0.1% | — | — | |
| Q2 2010 | +5.1% | — | — | |
| Q2 2009 | +5.1% | — | — | |
| Q1 2010 | -0.8% | — | — | |
| Q1 2009 | -0.8% | — | — | |
| Q4 2009 | -0.8% | — | — |
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