NASDAQ$SLN
Silence Therapeutics Plc · Q4 2025 earnings
Q4 2025 earnings · · Before market open · Investor relations
Briefing
Silence Therapeutics reported Q4 2025 results with pipeline progress on siRNA programs.
Silence Therapeutics highlighted recent business achievements and reported fourth-quarter and full-year 2025 financial results for its siRNA therapeutics pipeline, including zerlasiran and partner programs.
- siRNA platform with partner-enabled economics.
- Q4 and FY2025 financial update.
- Zerlasiran and hematology/oncology pipeline.
- Cash runway and R&D investment pace.
- Licensing revenue potential from partners.
Headline financials
Revenue & EPS history
Silence Therapeutics · Revenue · Quarterly
$0
Forward guidance
Clinical and partnership milestones frame 2026 value drivers.
Tailwinds
- Validated siRNA technology platform.
- Partner funding can offset R&D.
- Multiple shots on goal in genetic medicines.
Headwinds
- Early-stage biotech losses continue.
- Regulatory and clinical trial risks.
- Competition in RNAi field.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports · overlaid with Q4 2025
-2.2%
Avg return
Earnings day
-1.1%
Avg return
5 days after
+4.4%
Avg return
30 days after
35%
7 / 20 earnings
Positive
+11.3%
Q2 2023
Best reaction
-16.7%
Q3 2024
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q2 2024 | — | — | — | |
| Q1 2026 | -5.8% | -7.7% | -16.3% | |
| Q4 2025 | -6.0% | +4.2% | -0.7% | |
| Q3 2025 | +2.9% | +7.7% | +11.5% | |
| Q2 2025 | +0.2% | +5.1% | +7.0% | |
| Q1 2025 | -1.7% | +26.6% | +31.3% | |
| Q4 2024 | -1.0% | -6.1% | -27.9% | |
| Q3 2024 | -16.7% | -54.3% | -57.7% | |
| Q4 2023 | -8.0% | -7.3% | -14.4% | |
| Q3 2023 | +4.6% | +1.0% | +74.5% | |
| Q2 2023 | +11.3% | +14.2% | +62.6% | |
| Q1 2023 | -7.2% | +1.9% | +3.9% | |
| Q4 2022 | -6.9% | -6.6% | -35.8% | |
| Q3 2022 | +10.7% | +17.4% | +32.1% | |
| Q2 2022 | -2.3% | -3.6% | +22.1% | |
| Q1 2022 | -1.8% | -14.6% | -6.1% | |
| Q4 2021 | -0.8% | +6.7% | +0.6% | |
| Q2 2021 | -14.3% | -11.8% | -9.7% | |
| Q1 2021 | +0.2% | +13.2% | +9.6% | |
| Q4 2020 | +0.2% | +0.2% | +13.7% | |
| Q3 2020 | -2.5% | -9.0% | -13.3% | |
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