NASDAQ$MGNX
MacroGenics Inc · Q4 2025 earnings
Q4 2025 earnings · · After market close · Investor relations
Briefing
MacroGenics reported strong Q4 revenue driven by collaboration and contract manufacturing activity, returning to profitability after losses earlier in the year.
MacroGenics generated significant collaboration and manufacturing revenue in Q4 2025, leading to positive operating income and net income following losses earlier in the year. The quarter reflected milestone and collaboration payments as well as increased contract manufacturing activity.
- Q4 revenue was approximately 41227000 calculated from full-year results after strong earlier collaboration revenue.
- The company generated positive operating income and net income in the fourth quarter.
- Contract manufacturing and collaboration agreements continued to drive the majority of revenue.
- MacroGenics ended the year with a strong balance sheet and significant cash reserves to fund development.
Headline financials
Revenue & EPS history
MacroGenics · Revenue · Quarterly
$41.2M
Revenue by segment
MacroGenics · $9.5M total across 3 segments · Q3 2023
- Product Sales$4.7M—49.4%
- Contract Manufacturing$4.46M+290.7%47.0%
- Government Agreements$345K-36.9%3.6%
Forward guidance
MacroGenics expects continued investment in its oncology pipeline and expects its cash position to support development programs and operations into the coming years.
Tailwinds
- Strong collaboration relationships with major pharmaceutical partners.
- Multiple clinical catalysts expected from ADC and DART programs.
- Contract manufacturing operations generate recurring revenue.
- Significant cash reserves provide funding runway.
- Potential milestone and royalty payments from partners.
Headwinds
- Revenue remains highly dependent on milestone and collaboration payments.
- Pipeline development requires substantial R&D spending.
- Commercial product revenue is currently limited.
- Future results depend on clinical and regulatory outcomes.
- Biotechnology funding and partnership markets remain volatile.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 19 quarterly earnings reports · overlaid with Q4 2025
+5.6%
Avg return
Earnings day
+4.0%
Avg return
5 days after
+3.2%
Avg return
30 days after
44%
23 / 52 earnings
Positive
+251.7%
Q1 2020
Best reaction
-77.4%
Q1 2024
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | -0.9% | +24.0% | — | |
| Q4 2025 | +45.3% | +27.1% | +45.8% | |
| Q3 2025 | +8.3% | +4.8% | -4.8% | |
| Q1 2025 | +0.0% | +0.0% | -5.1% | |
| Q4 2024 | -4.8% | -25.7% | -40.0% | |
| Q3 2024 | +13.2% | +17.6% | -8.4% | |
| Q2 2024 | -5.6% | -1.7% | -5.6% | |
| Q1 2024 | -77.4% | -69.6% | -69.1% | |
| Q4 2023 | -18.8% | -18.0% | -15.0% | |
| Q3 2023 | +20.0% | +20.5% | +62.7% | |
| Q2 2023 | +26.6% | +13.7% | +4.7% | |
| Q1 2023 | -0.4% | -9.1% | -28.2% | |
| Q4 2022 | +8.4% | +3.7% | +0.6% | |
| Q3 2022 | +22.1% | +30.1% | +42.3% | |
| Q2 2022 | +16.2% | +18.9% | -3.6% | |
| Q1 2022 | -15.2% | -38.2% | -56.5% | |
| Q4 2021 | -3.6% | -8.1% | -12.7% | |
| Q3 2021 | +4.1% | +5.1% | -16.7% | |
| Q2 2021 | -5.5% | -5.7% | -10.3% | |
| Q1 2021 | -8.3% | -9.8% | -8.8% | |
| Q4 2020 | +18.7% | +16.1% | +57.6% | |
| Q3 2020 | +4.9% | +0.9% | +19.9% | |
| Q2 2020 | -1.5% | +3.1% | +5.9% | |
| Q1 2020 | +251.7% | +184.5% | +186.4% | |
| Q4 2019 | +8.5% | -20.8% | -45.5% | |
| Q3 2019 | -0.9% | -6.5% | +13.9% | |
| Q2 2019 | -0.3% | -9.1% | -2.5% | |
| Q1 2019 | +3.4% | +9.7% | +9.4% | |
| Q4 2018 | -2.8% | -5.8% | -19.4% | |
| Q3 2018 | +8.7% | -1.0% | -2.3% | |
| Q2 2018 | +6.3% | +9.5% | +11.1% | |
| Q1 2018 | -9.2% | -7.8% | +2.8% | |
| Q4 2017 | +2.1% | +17.7% | +2.4% | |
| Q3 2017 | -1.6% | -0.3% | +8.9% | |
| Q2 2017 | +6.6% | +8.0% | +17.8% | |
| Q1 2017 | -1.7% | -12.2% | -9.9% | |
| Q4 2016 | -5.1% | -2.7% | -15.8% | |
| Q3 2016 | -16.3% | -6.0% | +10.4% | |
| Q2 2016 | +6.8% | +1.1% | -2.2% | |
| Q1 2016 | -5.8% | — | — | |
| Q4 2015 | +5.1% | — | — | |
| Q3 2015 | -4.4% | — | — | |
| Q2 2015 | -12.1% | — | — | |
| Q1 2015 | +9.5% | — | — | |
| Q4 2014 | -0.2% | — | — | |
| Q3 2014 | +17.5% | — | — | |
| Q2 2013 | -4.8% | — | — | |
| Q2 2014 | -4.8% | — | — | |
| Q1 2013 | -5.0% | — | — | |
| Q1 2014 | -5.0% | — | — | |
| Q4 2013 | -7.6% | — | — | |
| Q3 2013 | +7.3% | — | — | |
| Q4 2012 | — | — | — | |
| Q3 2012 | — | — | — |
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