NASDAQ$CSTL
Castle Biosciences Inc · Q4 2025 earnings
Q4 2025 earnings · · After market close · Investor relations
Briefing
Castle Biosciences reported Q4 2025 revenue of $87.0M (+43% ex-SCC/IDgenetix) with FY revenue of $344.2M.
Fourth-quarter revenue was $87.0 million (+1% reported; +43% excluding DecisionDx-SCC and IDgenetix). Full-year revenue was $344.2 million with a net loss of $24.2 million after $45.9 million of stock-based compensation. Core test volumes for DecisionDx-Melanoma and TissueCypher rose 37%.
- Q4 revenue $87.0M.
- Core test reports +37% YoY.
- FY revenue $344.2M.
- Net loss $(24.2)M includes heavy SBC.
- Non-dermatologic tests $127.9M FY (+70%).
Headline financials
Revenue & EPS history
Castle Biosciences · Revenue · Quarterly
$87M
Forward guidance
2026 focuses on melanoma/TissueCypher growth after SCC coverage change and IDgenetix exit.
Tailwinds
- High-growth core dermatologic franchises.
- Expanding non-derm oncology menu.
Headwinds
- Medicare coverage change for DecisionDx-SCC.
- Revenue recognition timing on new tests.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2025
+0.1%
Avg return
Earnings day
-2.1%
Avg return
5 days after
+0.7%
Avg return
30 days after
41%
13 / 32 earnings
Positive
+21.8%
Q3 2025
Best reaction
-28.0%
Q4 2023
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +0.6% | -22.6% | -14.4% | |
| Q4 2025 | -7.3% | -11.6% | -26.2% | |
| Q3 2025 | +21.8% | +27.1% | +52.4% | |
| Q1 2025 | -11.7% | -10.5% | -9.2% | |
| Q4 2024 | -14.2% | -15.7% | -21.1% | |
| Q3 2024 | -6.0% | +0.4% | -3.8% | |
| Q2 2024 | +11.8% | +20.4% | +29.8% | |
| Q1 2024 | +10.5% | +8.1% | +5.6% | |
| Q4 2023 | -28.0% | -15.4% | -11.7% | |
| Q3 2023 | +14.5% | +14.6% | +27.2% | |
| Q2 2023 | +12.3% | +7.0% | +17.6% | |
| Q1 2023 | -0.2% | +2.6% | +3.0% | |
| Q4 2022 | -7.7% | -0.3% | -10.2% | |
| Q3 2022 | -6.0% | -23.7% | -0.4% | |
| Q2 2022 | +0.3% | +11.1% | -12.6% | |
| Q1 2022 | -4.1% | -6.8% | +3.1% | |
| Q4 2021 | +4.5% | -5.4% | -1.5% | |
| Q3 2021 | -7.2% | -13.2% | -23.2% | |
| Q2 2021 | -4.9% | -10.3% | +6.5% | |
| Q1 2021 | -9.5% | -8.5% | +17.5% | |
| Q4 2020 | -9.9% | -6.9% | +2.3% | |
| Q3 2020 | -3.3% | -2.6% | +12.3% | |
| Q2 2020 | +0.1% | -1.1% | +19.8% | |
| Q1 2020 | +17.1% | +18.9% | +22.4% | |
| Q1 2019 | +17.1% | +18.9% | +22.4% | |
| Q1 2018 | -1.5% | -18.2% | -4.7% | |
| Q4 2019 | -1.5% | -18.2% | -4.7% | |
| Q3 2018 | +20.0% | -7.0% | -6.1% | |
| Q3 2019 | +18.2% | +30.3% | +32.9% | |
| Q2 2018 | -6.9% | -9.0% | -33.8% | |
| Q2 2019 | -6.9% | -9.0% | -33.8% | |
| Q4 2018 | -6.9% | -9.0% | -33.8% |
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