NASDAQ$ATXS
Astria Therapeutics Inc · Q1 2025 earnings
Q1 2025 earnings · · After market close · Investor relations
Briefing
Astria Therapeutics, Inc. reported a net loss of $33.7 million for Q1 2025, with increased research and development expenses and a decrease in other income.
Astria Therapeutics, Inc. experienced a significant increase in net loss for the first quarter of 2025, primarily driven by higher research and development expenses related to its lead product candidates, navenibart and STAR-0310. The company's cash position remains strong, with sufficient funds to sustain operations into mid-2027.
- Net loss increased to $33.7 million in Q1 2025 from $19.9 million in Q1 2024, a 69% increase.
- Research and development expenses surged by 77% to $27.8 million, mainly due to milestone payments and clinical trial costs for navenibart and STAR-0310.
- General and administrative expenses saw a modest increase of 9% to $9.2 million, attributed to higher employee and stock-based compensation expenses.
- Other income, net, decreased by 22% to $3.3 million, primarily due to lower interest-earning assets and yields.
Headline financials
Revenue & EPS history
Astria · Revenue · Quarterly
$0
Forward guidance
Astria Therapeutics, Inc. anticipates continued significant research and development expenses in 2025 and beyond, driven by ongoing clinical trials and development activities for navenibart and STAR-0310. The company expects its current cash, cash equivalents, and short-term investments to fund operations into mid-2027, but acknowledges the need for substantial additional financing to complete product development and commercialization.
Tailwinds
- Existing cash, cash equivalents, and short-term investments are expected to fund operating expenses and capital expenditure requirements into mid-2027.
- Continued development of navenibart, including support for all program activities through completion of ALPHA-ORBIT Phase 3 trial and related ORBIT-EXPANSE long-term trial.
- Completion of the ongoing Phase 1a clinical trial of STAR-0310 in healthy subjects.
- Potential for future collaborations, strategic alliances, or licensing arrangements to secure additional funding.
- Ongoing efforts to develop autoinjector and pre-filled syringe drug device combinations for navenibart to ease administration.
Headwinds
- Significant additional capital will be required to complete the development and commercialization of product candidates.
- No assurance that adequate additional financing will be available on acceptable terms or at all.
- Failure to obtain sufficient funds could lead to inability to continue operations at planned levels, or force modification, reduction, or termination of business strategies.
- Uncertainty regarding the exact amount of operating capital requirements due to numerous risks and uncertainties in biotechnology product development.
- Potential for changing circumstances, some beyond control, to cause capital consumption significantly faster than currently anticipated.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 7 quarterly earnings reports · overlaid with Q1 2025
+1.3%
Avg return
Earnings day
+1.4%
Avg return
5 days after
+0.6%
Avg return
30 days after
52%
22 / 42 earnings
Positive
+19.8%
Q4 2018
Best reaction
-11.6%
Q2 2021
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q4 2025 | — | — | — | |
| Q3 2025 | +0.2% | +0.5% | +3.3% | |
| Q2 2025 | +3.0% | +1.7% | +11.7% | |
| Q1 2025 | +7.3% | +2.8% | +49.7% | |
| Q4 2024 | +11.2% | +10.8% | -30.2% | |
| Q3 2024 | -9.6% | -17.8% | -14.7% | |
| Q2 2024 | +10.9% | +18.4% | +12.1% | |
| Q1 2024 | +1.7% | -0.9% | -7.6% | |
| Q4 2023 | -7.5% | -4.1% | -19.3% | |
| Q3 2023 | -2.0% | — | — | |
| Q2 2023 | -2.0% | — | — | |
| Q1 2023 | -0.4% | — | — | |
| Q4 2022 | +2.3% | — | — | |
| Q3 2022 | +7.9% | — | — | |
| Q2 2022 | +3.3% | — | — | |
| Q1 2022 | -2.8% | — | — | |
| Q4 2021 | +2.7% | — | — | |
| Q3 2021 | +5.4% | — | — | |
| Q2 2021 | -11.6% | — | — | |
| Q1 2021 | +0.6% | — | — | |
| Q4 2020 | +11.6% | — | — | |
| Q3 2020 | -1.4% | — | — | |
| Q2 2020 | +1.5% | — | — | |
| Q1 2020 | -0.7% | — | — | |
| Q4 2019 | -5.5% | — | — | |
| Q3 2019 | -1.3% | — | — | |
| Q2 2019 | +1.1% | — | — | |
| Q1 2019 | +12.7% | — | — | |
| Q4 2018 | +19.8% | — | — | |
| Q3 2018 | -0.8% | — | — | |
| Q2 2018 | -4.5% | — | — | |
| Q1 2018 | -8.9% | — | — | |
| Q4 2017 | +2.1% | — | — | |
| Q3 2017 | +0.0% | — | — | |
| Q2 2017 | -1.2% | — | — | |
| Q1 2017 | -1.5% | — | — | |
| Q4 2016 | -11.4% | — | — | |
| Q3 2016 | +14.4% | — | — | |
| Q2 2016 | -2.7% | — | — | |
| Q1 2016 | +6.0% | — | — | |
| Q4 2015 | +6.9% | — | — | |
| Q3 2015 | -8.0% | — | — | |
| Q2 2015 | +5.0% | — | — | |
| Q1 2015 | — | — | — | |
| Q3 2014 | — | — | — | |
| Q2 2014 | — | — | — | |
| Q4 2013 | — | — | — |
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