NASDAQ$ALKS
Alkermes plc · Q4 2025 earnings
Q4 2025 earnings · · Before market open · Investor relations
Briefing
Alkermes reported Q4 2025 total revenues of $384.5 million with GAAP net income of $49.3 million.
Alkermes generated Q4 2025 total revenues of $384.5 million with proprietary net sales of $315.5 million (+2.5% YoY). GAAP net income was $49.3 million; full-year 2025 revenue was $1.48 billion with GAAP net income $242 million ($1.43 diluted EPS). Key products: LYBALVI $94.1M (+22%), ARISTADA $97.2M, VIVITROL $124.1M in Q4. Management expects to initiate alixorexton Phase 3 in narcolepsy in Q1 2026 following the Avadel acquisition.
- Q4 revenue $384.5M; proprietary net sales $315.5M.
- Q4 GAAP net income $49.3M; FY EPS $1.43 on $1.48B revenue.
- LYBALVI +22% YoY; VIVITROL $124.1M in Q4.
- Alixorexton Phase 3 in narcolepsy expected Q1 2026.
Headline financials
Revenue & EPS history
Alkermes · Revenue · Quarterly
$385M
Revenue by segment
Alkermes · $232M total across 3 segments · Q3 2023
- VIVITROL$99.3M+2.9%42.8%
- ARISTADA$81.8M+8.1%35.3%
- LYBALVI$50.7M+87.1%21.9%
Forward guidance
Alkermes provided 2026 financial expectations with the release, emphasizing cash generation, alixorexton registrational studies, and LUMRYZ integration from Avadel.
Tailwinds
- Diversified CNS commercial portfolio with profitability.
- Avadel acquisition expands sleep medicine footprint ahead of alixorexton.
- Strong balance sheet to fund orexin pipeline.
Headwinds
- VIVITROL and legacy product growth constraints.
- Pipeline execution risk on alixorexton and orexin candidates.
- Generic and competitive pressure in psychiatry markets.
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 20 quarterly earnings reports · overlaid with Q4 2025
-0.6%
Avg return
Earnings day
-0.0%
Avg return
5 days after
-0.5%
Avg return
30 days after
45%
27 / 60 earnings
Positive
+16.6%
Q4 2017
Best reaction
-14.8%
Q1 2020
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q1 2026 | +6.2% | +2.5% | +27.0% | |
| Q4 2025 | -6.6% | -9.4% | -12.0% | |
| Q3 2025 | +3.9% | +3.3% | +0.0% | |
| Q1 2025 | +6.3% | +5.5% | +6.4% | |
| Q4 2024 | +4.8% | +12.3% | +6.5% | |
| Q3 2024 | -6.3% | -5.1% | +3.3% | |
| Q2 2024 | +12.2% | +11.7% | +11.8% | |
| Q1 2024 | -2.8% | -1.8% | -4.6% | |
| Q4 2023 | +15.0% | +8.6% | +2.7% | |
| Q3 2023 | -2.4% | -4.0% | -3.7% | |
| Q2 2023 | -1.8% | -5.1% | -11.9% | |
| Q1 2023 | -7.1% | -6.1% | -3.9% | |
| Q4 2022 | +4.0% | +2.9% | -3.6% | |
| Q3 2022 | +3.8% | +0.3% | +12.2% | |
| Q2 2022 | -9.7% | -14.4% | -16.5% | |
| Q1 2022 | +9.8% | +6.4% | +12.5% | |
| Q4 2021 | +8.8% | +7.6% | +12.1% | |
| Q3 2021 | -8.2% | -5.0% | -28.7% | |
| Q2 2021 | +5.9% | +11.6% | +28.9% | |
| Q1 2021 | -3.2% | -1.6% | +0.8% | |
| Q4 2020 | -11.8% | -13.7% | -15.3% | |
| Q3 2020 | +5.6% | +5.9% | +20.2% | |
| Q2 2020 | -8.8% | -7.4% | -19.0% | |
| Q1 2020 | -14.8% | -14.7% | +1.6% | |
| Q4 2019 | -7.0% | -7.8% | -15.5% | |
| Q3 2019 | +5.7% | +6.0% | +13.9% | |
| Q2 2019 | -10.2% | +1.2% | -12.3% | |
| Q1 2019 | -12.2% | -12.7% | -31.1% | |
| Q4 2018 | -1.2% | +3.6% | +3.3% | |
| Q3 2018 | +3.0% | +6.5% | -11.6% | |
| Q2 2018 | -0.1% | -0.3% | +2.0% | |
| Q1 2018 | +1.5% | +1.4% | +3.9% | |
| Q4 2017 | +16.6% | +23.0% | +12.0% | |
| Q3 2017 | +0.7% | -1.5% | +3.2% | |
| Q2 2017 | -4.1% | -5.4% | -12.4% | |
| Q1 2017 | +2.0% | +2.4% | +1.0% | |
| Q4 2016 | -2.9% | -4.6% | +3.7% | |
| Q3 2016 | -1.4% | +4.0% | +8.4% | |
| Q2 2016 | -3.6% | -6.0% | -14.1% | |
| Q1 2016 | -2.0% | — | — | |
| Q4 2015 | -1.4% | — | — | |
| Q3 2015 | +7.6% | — | — | |
| Q2 2015 | +2.4% | — | — | |
| Q1 2015 | +3.1% | — | — | |
| Q4 2014 | -3.4% | — | — | |
| Q3 2014 | +7.7% | — | — | |
| Q2 2014 | -7.2% | — | — | |
| Q1 2014 | +3.2% | — | — | |
| Q4 2013 | -7.7% | — | — | |
| Q3 2013 | -3.7% | — | — | |
| Q2 2013 | +3.5% | — | — | |
| Q1 2013 | +3.9% | — | — | |
| Q4 2010 | -1.0% | — | — | |
| Q4 2012 | -9.9% | — | — | |
| Q3 2012 | +2.2% | — | — | |
| Q3 2011 | +2.2% | — | — | |
| Q2 2011 | -7.7% | — | — | |
| Q2 2012 | -7.7% | — | — | |
| Q4 2011 | -7.7% | — | — | |
| Q2 2010 | -3.0% | — | — |
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